Search results for " generation."
showing 10 items of 1108 documents
A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines
2014
Cancer cell lines are a tremendous resource for cancer biology and therapy development. These multipurpose tools are commonly used to examine the genetic origin of cancers, to identify potential novel tumor targets, such as tumor antigens for vaccine devel-opment, and utilized to screen potential therapies in preclinical studies. Mutations, gene expression, and drug sensitivity have been determined for many cell lines using next-generation sequencing (NGS). However, the human leukocyte antigen (HLA) type and HLA expression of tumor cell lines, characterizations necessary for the development of cancer vaccines, have remained largely incomplete and, such information, when available, has been …
Probing the Dynamics of a Molecular Ion with Laser Pulses
2004
The dynamics of a H2+ molecular ion driven by two laser pulses separated by a time lag is studied beyond the Born-Oppenheimer approximation. The first, short, pulse prepares the molecule in some quantum state, which is probed by the second pulse. Under suitable conditions, the molecule emits a spectrum of redshifted high-order harmonics. The value of the redshift is proportional to the harmonic order and can be used as a measure of the speed of the atoms of the molecule.
Microwave Response of Ceramic MgB2 Samples
2009
The microwave response of ceramic MgB2 has been investigated as a function of temperature and external magnetic field by two different techniques: microwave surface impedance and second-harmonic emission measurements. The measurements of the surface resistance have shown that microwave losses in MgB2 are strongly affected by the magnetic field in the whole range of temperatures below Tc, even for relatively low field values. The results have been accounted for in the framework of the Coffey and Clem model hypothesizing that in different temperature ranges the microwave current induces fluxons to move in different regimes. In particular, the results at temperatures close to Tc have been quan…
Alignement moléculaire : caractérisation et application à la mesure de thermalisation ultra-rapide et au contrôle de génération d'harmoniques
2013
The thematic of this thesis is molecular alignment. The latter is a very important topic that opens the way toward a much more thin control of many phenomenons. So, we have developed a new measurement technique of the molecular alignment along one axis that permits to preserve the sign of alignment. This one is, like other measurement techniques developed by the team,based on the measurement of the refractive index variation induced by the molecular alignment.The technique developed then also permits the molecular alignment measurement, being also an application of it because it allows the third harmonic generation. In the last study, molecular alignment is implemented to show that it bring…
Harmonic generation in all-dielectric metasurfaces
2023
Nonlinear light generation is a key phenomenon in many optical systems. Recently, the field of nonlinear optics has moved to the miniaturization of conventional bulky components. Among all the new platforms that have been proposed, dielectric nanoscale resonators represent excellent candidates for light generation and manipulation. When arranged in periodic arrays, such high refractive index scattering components become an artificial material called metasurface. Several approaches for designing platforms with enhanced optical nonlinearities at moderate pump intensities have been proposed. In this chapter, we review the most recent results on second- and third-order nonlinear processes in hi…
Dynamical generation of wormholes with charged fluids in quadratic Palatini gravity
2014
The dynamical generation of wormholes within an extension of General Relativity (GR) containing (Planck's scale-suppressed) Ricci-squared terms is considered. The theory is formulated assuming the metric and connection to be independent (Palatini formalism) and is probed using a charged null fluid as a matter source. This has the following effect: starting from Minkowski space, when the flux is active the metric becomes a charged Vaidya-type one, and once the flux is switched off the metric settles down into a static configuration such that far from the Planck scale the geometry is virtually indistinguishable from that of the standard Reissner-Nordstr\"om solution of GR. However, the innerm…
Gravitational footprints of massive neutrinos and lepton number breaking
2020
We investigate the production of primordial Gravitational Waves (GWs) arising from First Order Phase Transitions (FOPTs) associated to neutrino mass generation in the context of type-I and inverse seesaw schemes. We examine both "high-scale" as well as "low-scale" variants, with either explicit or spontaneously broken lepton number symmetry $U(1)_L$ in the neutrino sector. In the latter case, a pseudo-Goldstone majoron-like boson may provide a candidate for cosmological dark matter. We find that schemes with softly-broken $U(1)_L$ and with single Higgs-doublet scalar sector lead to either no FOPTs or too weak FOPTs, precluding the detectability of GWs in present or near future measurements.…
Pinch Technique: Theory and Applications
2009
We review the theoretical foundations and the most important physical applications of the Pinch Technique (PT). This general method allows the construction of off-shell Green’s functions in non-Abelian gauge theories that are independent of the gauge-fixing parameter and satisfy ghost-free Ward identities. We first present the diagrammatic formulation of the technique in QCD, deriving, at one loop, the gauge independent gluon self-energy, quark–gluon vertex, and three-gluon vertex, together with their Abelian Ward identities. The generalization of the PT to theories with spontaneous symmetry breaking is carried out in detail, and the profound connection with the optical theorem and the disp…
Optimal estimation of losses at the ultimate quantum limit with non-Gaussian states
2009
We address the estimation of the loss parameter of a bosonic channel probed by arbitrary signals. Unlike the optimal Gaussian probes, which can attain the ultimate bound on precision asymptotically either for very small or very large losses, we prove that Fock states at any fixed photon number saturate the bound unconditionally for any value of the loss. In the relevant regime of low-energy probes, we demonstrate that superpositions of the first low-lying Fock states yield an absolute improvement over any Gaussian probe. Such few-photon states can be recast quite generally as truncations of de-Gaussified photon-subtracted states.
Coupled dynamics in gluon mass generation and the impact of the three-gluon vertex
2018
We present a detailed study of the subtle interplay transpiring at the level of two integral equations that are instrumental for the dynamical generation of a gluon mass in pure Yang-Mills theories. The main novelty is the joint treatment of the Schwinger-Dyson equation governing the infrared behaviour of the gluon propagator and of the integral equation that controls the formation of massless bound-state excitations, whose inclusion is instrumental for obtaining massive solutions from the former equation. The self-consistency of the entire approach imposes the requirement of using a single value for the gauge coupling entering in the two key equations; its fulfillment depends crucially on …