Search results for " generation."
showing 10 items of 1108 documents
Enhanced thrombin generation in patients with cirrhosis-induced coagulopathy.
2010
Summary. Background: Prothrombin time (PT) and the international normalized ratio (INR) are still routinely measured in patients with liver cirrhosis to ‘assess’ their bleeding risk despite the lack of correlation with the two. Thrombin generation (TG) assays are global assays of coagulation that are showing promise in assessing bleeding and thrombosis risks. Aim: To study the relationship between the INR and TG profiles in cirrhosis-induced coagulopathy. Methods: Seventy-three patients with cirrhosis were studied. All TG parameters were compared with those from a normal control group. Contact activation was prevented using corn trypsin inhibitor. TG was also assayed in the presence of Prot…
Intestinal malrotation in a female newborn affected by Osteopathia Striata with Cranial Sclerosis due to a de novo heterozygous nonsense mutation of …
2022
Abstract Background Osteopathia Striata with Cranial Sclerosis (OS-CS), also known as Horan-Beighton Syndrome, is a rare genetic disease; about 90 cases have been reported to date. It is associated with mutations (heterozygous for female subjects and hemizygous for males) of the AMER1 gene, located at Xq11.2, and shows an X-linked pattern of transmission. Typical clinical manifestations include macrocephaly, characteristic facial features (frontal bossing, epicanthal folds, hypertelorism, depressed nasal bridge, orofacial cleft, prominent jaw), hearing loss and developmental delay. Males usually present a more severe phenotype than females and rarely survive. Diagnostic suspicion is based o…
ITPA deficiency and ribavirin level are still predictive of anaemia in HCV–HIV-coinfected patients receiving ribavirin combined with a first-generati…
2017
Background We aimed to determine the impact of inosine triphosphatase (ITPA) deficiency on ribavirin (RBV)-induced anaemia in HIV–HCV-coinfected patients receiving a triple therapy including the haematotoxic direct-acting antiviral agent boceprevir (BOC). Methods Patients of the ANRS HC27 BocepreVIH study were genotyped for two ITPA single nucleotide polymorphisms involved in ITPA deficiency. RBV trough concentration (Ctrough) was determined at week (W)4 and W8. Impact of ITPA deficiency on anaemia, RBV Ctrough, response and haematotoxicity (grade 3/4 anaemia, erythropoietin [EPO] use, RBV dose reduction or transfusion between day [D]0 and W8) was evaluated. Impact of RBV Ctrough on anaemia…
COMPARING THE MARSHALL PLAN AND THE EUROPEAN NEXT GENERATION UE. Models and Legal Tools of International and Supernational Cooperation to Promote Eco…
2022
The article analyzes and compares the European Recovery Plan of 1948, commonly known as the Marshall Plan, for the reconstruction of Europe after the Second World War (paragraphs 2, 2.1, 2.2), and the Next Generation EU (paragraphs 3, 3.1) through the lens and methods of legal comparison and historical analysis. As the description of the law cannot ignore the historicization of the object of study, such comparison is carried out inductively, through the analysis of the legal mechanisms in their concrete attitudes and the construction of descriptive schemes of facts, having regard to the legal discipline, but also to the functional profiles and the context in which the rules are conceived. T…
The ultrafast dynamics and conductivity of photoexcited graphene at different Fermi energies
2017
The ultrafast dynamics and conductivity of photoexcited graphene can be explained using solely electronic effects.
Reexamining Different Factors of the Resonance-Enhanced High-Order Harmonic Generation in Atomic and Nanoparticle Laser-Induced Tin Plasmas
2021
We reexamine the resonance enhancement of a single harmonic emission during the propagation of ultrafast pulses through atomic and nanoparticle tin-containing laser-induced plasma (LIP). We compare the single atomic Sn and Sn nanoparticle plasmas to demonstrate a distinction in the enhancement factor of the single harmonic in the case of fixed and tunable near-infrared pulses. The analysis of the dynamics of Sn LIP shows the range of optimal delays between heating and driving pulses (130–180 ns), at which the maximal harmonic yield can be achieved. The enhancements of the 17th and 18th harmonics of 806 nm pulses were analyzed in the case of single-color and two-color pumps of LIP, showing u…
Surface-Specific Spectroscopy of Water at a Potentiostatically Controlled Supported Graphene Monolayer
2019
Knowledge of the structure of interfacial water molecules at electrified solid materials is the first step toward a better understanding of important processes at such surfaces, in, e.g., electrochemistry, atmospheric chemistry, and membrane biophysics. As graphene is an interesting material with multiple potential applications such as in transistors or sensors, we specifically investigate the graphene–water interface. We use sum-frequency generation spectroscopy to investigate the pH- and potential-dependence of the interfacial water structure in contact with a chemical vapor deposited (CVD) grown graphene surface. Our results show that the SFG signal from the interfacial water molecules a…
Liquid–solid interfaces: structure and dynamics from spectroscopy and simulations
2014
Liquid–solid interfaces play an important role in a number of phenomena encountered in biological, chemical and physical processes. Surface-induced changes of the material properties are not only important for the solid support but also for the liquid itself. In particular, it is now well established that water at the interface is substantially different from bulk water, even in the proximity of apparently inert surfaces such as a simple metal. The complex chemistry at liquid–solid interfaces is typically fundamental to heterogeneous catalysis and electrochemistry, and has become especially topical in connection with the search for new materials for energy production. A quite remarkable exa…
Defect characterization in Al welded joints by non-contact Lamb wave technique
2006
Abstract The use of air-coupled sensors to detect flaws in Al welded joints and the advantage of Lamb wave for their characterization has been proved. Ultrasonic waves were generated by a pulsed laser and by contact angle-beam transducer, and received by an air-coupled capacitive transducer. Laser-based configuration was used to quickly locate the defect, whereas the angle-beam contact probe configuration to characterize it thanks to the dispersive behavior of Lamb waves. Guided waves allow inspection of the complete thickness with only one scan, permitting to detect and to size both internal and surface defects; their high flexibility in the measurement is due to the various parameters cha…
Comparing different processing methods in apple slice drying. Part 1. Performance of microwave, hot air and hybrid methods at constant temperatures
2019
The drying curves, energy efficiency and colour variations of sliced apples dried at various temperatures and using different techniques were evaluated, i.e. microwave (35, 55 and 65 °C), hot air (35, 55, 65 and 75 °C) and combination of both (65 °C). The microwave (MW) tests also included comparison between air recirculation and continuous inlet of fresh air. Each drying method was evaluated at a fixed temperature level by means of a control system based on infrared thermography. The time required to complete the drying process at 65 °C varied from about 44 min for MW with fresh air ventilation (double with air recirculation), to 122 min for hybrid heating and 238 min for hot air. Drying k…