Search results for " geni"
showing 10 items of 1026 documents
Investigation of inhibitory effects on EPC-mediated neovascularization by different bisphosphonates for cancer therapy.
2013
Bisphosphonates (BPs) are potent drugs, used in metastatic cancer-like prostate or breast carcinoma. In recent studies, besides reduced bone remodeling, influences on angiogenesis and neovascularization were reported. Since BPs have the tendency to accumulate in the bones, the biological effect of various nitrogen- and non-nitrogen BPs on endothelial progenitor cells (EPCs) that originated from bone marrow and mobilized under physiological and pathophysiological conditions, such as tumor neovascularization, was investigated. EPCs subsequent to 72-h treatment with different concentrations of bisphosphonates comprised the non-nitrogen-containing BP clodronate and the nitrogen-containing BPs i…
P68 A diet rich in wheat alpha-amylase/trypsin inhibitors (ATIs) enhances disease progression in the MRL-Fas(lpr) mouse model of systemic lupus eryth…
2020
Background Wheat alpha-amylase/trypsin inhibitors (ATIs) are the second most prevalent proteins in wheat (3–4% vs 80–90% for gluten) and potent activators of the innate immune system via the toll like receptor 4 (TLR4)-MD2-CD14 complex in cells of the mononuclear phagocyte system (Junker Y et al, J Exp Med 2012), triggering several autoimmune/inflammatory diseases. In contrast, pure gluten that is de-enriched of ATIs shows no stimulatory activity. MRL-Fas(lpr) mice develop progressive and spontaneous glomerular, tubulointerstitial and perivascular kidney disease, arthritis, lymphadenopathy, splenomegaly and circulating autoantibodies in a syndrome that resembles systemic lupus erythematosus…
Autoantikörper gegen die Komplementkomponente C1q beim Systemischen Lupus Erythematodes
1990
Autoantibodies against C1q, a subcomponent of the first complement component C1, could be detected in 49.4% of sera from patients with systemic lupus erythematosus (SLE). They are directed against the collagen-like portion of the C1q molecule and recognize only bound, but not fluid-phase C1q. The appearance of these autoantibodies in the course of SLE correlates with the detection of IgG in the C1q-Solid-Phase-Bindingassay, with high titres of dsDNA-antibodies and with depressed total complement activity (CH50) and C1q-values. Our investigations show that autoantibodies against the collagen-like portion of bound C1q but not immune complexes are the main constituent of C1q-binding IgG in SLE.
Heat Shock Proteins in Renal Cell Carcinomas
2005
Renal cell carcinoma (RCC) represents one of the most common cancer types in the Western World. One third of the RCC patients had metastasis at presentation with a poor 5-year survival. Nephrectomy is the most important treatment modality of this disease, since most of the RCCs are resistant to cytotoxic chemotherapy and radiation therapy. Recent immunotherapeutic approaches have been shown to improve the survival rate of RCC patients. Thus, RCC appears to have an immunogenic basis, and therefore represents an attractive target for immunotherapies. So far, only a few RCC-associated antigens have been characterized. However, with the implementation of ome-based technologies, an increasing nu…
Uric acid and uric acid/creatinine ratio and their correlations with the hemorheological determinants in subjects with subclinical carotid atheroscle…
2022
BACKGROUND AND OBJECTIVE: we have examined the concentration of serum uric acid and the serum uric acid/creatinine ratio as well as their correlations with the main determinants of the hemorheological profile in a group of subjects with subclinical carotid atherosclerosis. METHODS: we evaluated the concentration of serum uric acid and the serum uric acid/creatine ratio in 43 men and 57 women [median age 66.00 (25)] with subclinical carotid atherosclerosis, subsequently divided according to the number of traditional cardiovascular risk factors and to the insulin resistance degree. RESULTS: serum uric acid, but not the serum uric acid/creatinine ratio, results strongly influenced by the numbe…
Renal function is impaired in normotensive chronic HCV patients: role of insulin resistance.
2015
Renal dysfunction is an independent predictor for cardiovascular morbidity and mortality. We investigated whether chronic hepatitis C virus (HCV) infection and the related insulin resistance/hyperinsulinemia influence renal function in comparison with a group of healthy subjects and with another group with metabolic syndrome. We enrolled 130 newly diagnosed HCV outpatients matched for age and gender with 130 patients with metabolic syndrome and 130 healthy subjects. Renal function was evaluated by calculation of glomerular filtration rate (e-GFR, mL/min/1.73 m2) using the CKD-EPI equation. The following laboratory parameters were measured: fasting plasma glucose and insulin, total, LDL- and…
Carotenoid-based colour polyphenism in a moth species: search for fitness correlates
2007
Carotenoid-based integumental coloration is often associated with individual performance in various animals. This is because the limited amount of the pigment has to be allocated to different vital functions. However, most of the evidence for the carotenoid-based trade-off comes from vertebrate studies, and it is unclear if this principle can be applied to insects. This possibility was investigated in Orgyia antiqua L. (Lepidoptera: Lymantriidae). The larvae of this species are polyphenic in their coloration, varying from a highly conspicuous combination of yellow hair tufts on black background to cryptic appearance with brown hair tufts. The conspicuous larvae are aposematic, advertising t…
Come ascoltare i figli e come farsi ascolatre
2010
In questo breve saggio, sono delineate alcune caratteristiche che la comunicazione reale tra genitori e figli dovrebbe possedere, secondo il personale punto di vista pedagogico dell’autore. A ben vedere, per realizzare questo compito, bisogna prima interpellare i genitori su quello che già sanno sul tema a motivo della loro quotidiana esperienza educativa vissuta a contatto con i loro figli preadolescenti (11-14 anni) e adolescenti (15-19 anni). Per questo, innanzitutto si riferiscono alcune idee sul tema in questione espresse nel contesto dei focus group dai genitori che hanno partecipato agli incontri pedagogici fatti in alcune scuole secondarie di primo e di secondo grado della nostra re…
La formazione dei genitori: un modello di intervento in contesti socioculturali "a rischio"
2013
This article presents a possible model of parents’ training in an area at risk by a socio-economic and cultural point of view. It clarifies the theoretical framework that, during four years, has been the basis for the design, the implementation and the evaluation of several actions in a primary school in the city of Palermo. From this theoretical framework, which concern primarily the eco-systemic and socioconstructivist perspectives, some basic points are enucleated, such as the concepts of "context" and of empowerment. Some methodological and operational choices are also explained, in line with this approach, such as: the dimension of the working group, the narrative and the life stories …
I congedi genitoriali nella prospettiva del family act
2021
il saggio analizza la disciplina dei congedi genitoriali alla luce delle criticità esistenti e delle prospettive di riforme dischiuse dal d.dl. famiglia (cd Family act)