6533b86dfe1ef96bd12ca8f1

RESEARCH PRODUCT

Autoantikörper gegen die Komplementkomponente C1q beim Systemischen Lupus Erythematodes

Ursula AntesMichael LoosK. HartungHans-peter Heinz

subject

business.industryAutoantibodychemical and pharmacologic phenomenaGeneral Medicineurologic and male genital diseasesComplement activityfluids and secretionsImmune systemimmune system diseasesDrug DiscoveryImmunologyMolecular MedicineMedicineskin and connective tissue diseasesbusinessGenetics (clinical)Anti-SSA/Ro autoantibodies

description

Autoantibodies against C1q, a subcomponent of the first complement component C1, could be detected in 49.4% of sera from patients with systemic lupus erythematosus (SLE). They are directed against the collagen-like portion of the C1q molecule and recognize only bound, but not fluid-phase C1q. The appearance of these autoantibodies in the course of SLE correlates with the detection of IgG in the C1q-Solid-Phase-Bindingassay, with high titres of dsDNA-antibodies and with depressed total complement activity (CH50) and C1q-values. Our investigations show that autoantibodies against the collagen-like portion of bound C1q but not immune complexes are the main constituent of C1q-binding IgG in SLE.

yearjournalcountryeditionlanguage
1990-11-01Klinische Wochenschrift
https://doi.org/10.1007/bf01649307