Search results for " growth"

2021

Abstract Research-based discussions about 21st-century skills are currently needed; 21st-century skills refer to skills that today's students are expected to possess for successful future careers. The ways students perceive these skills or what kind of dispositions they have in this regard are significant. This paper provides an overview of the development of pre-service teachers' perceived 21st-century skills and dispositions. The quantitative data was collected in three phases during 2014, 2015, and 2016 at three Finnish universities. The number of respondents at each measurement point varied from 209 to 267. Data were analysed using latent growth curve modeling. The study focuses on stud…

Learning from the past in the COVID-19 era: rediscovery of quarantine, previous pandemics, origin of hospitals and national healthcare systems, and e…

2020

Abstract After the dramatic coronavirus outbreak at the end of 2019 in Wuhan, Hubei province, China, on 11 March 2020, a pandemic was declared by the WHO. Most countries worldwide imposed a quarantine or lockdown to their citizens, in an attempt to prevent uncontrolled infection from spreading. Historically, quarantine is the 40-day period of forced isolation to prevent the spread of an infectious disease. In this educational paper, a historical overview from the sacred temples of ancient Greece—the cradle of medicine—to modern hospitals, along with the conceive of healthcare systems, is provided. A few foods for thought as to the conflict between ethics in medicine and shortage of personne…

A Probabilistic Model for Crystal Growth Applied toProtein Deposition at the Microscale.

2018

A probabilistic discrete model for 2D protein crystal growth is presented. This model takes into account the available space and can describe growing processes of a different nature due to the versatility of its parameters, which gives the model great flexibility. The accuracy of the simulation is tested against a real recrystallization experiment, carried out with the bacterial protein SbpA from Lysinibacillus sphaericus CCM2177, showing high agreement between the proposed model and the actual images of the crystal growth. Finally, it is also discussed how the regularity of the interface (i.e., the curve that separates the crystal from the substrate) affects the evolution of the simulation.

Synthesis, antiproliferative activity and possible mechanism of action of novel 2-acetamidobenzamides bearing the 2-phenoxy functionality.

2015

Several new 2-(2-phenoxyacetamido)benzamides 17a-v, 21 and 22 were synthesized by stirring in pyridine the acid chlorides 16a-e and the appropriate5-R-4-R1-2-aminobenzamide 15a-e and initially evaluated in vitro for antiproliferative activity against the K562 (human chronic myelogenous leukemia) cell line. Some of synthesized compounds were evaluated for their in vitro antiproliferative activity against the full NCI tumor cell line panel derived from nine clinically isolated cancer types (leukemia, non-small cell lung, colon, CNS, melanoma, ovarian, renal, prostate and breast). The most active compounds caused an arrest of K562 cells in the G0-G1 phase of cell cycle and induction of apoptos…

Spray dried hyaluronic acid microparticles for adhesion controlled aggregation and potential stimulation of stem cells

2017

Spray-dried microparticles of a derivative of hyaluronic acid (HA) have been engineered to obtain a controlled aggregation with Human Mesenchymal Stem Cells (hMSCs) into 3D constructs. We demonstrated the utility of chemical functionalization of a native constituent of the extracellular matrix to improve processing performances and to control on stem cell adhesion and differentiation. Native hyaluronic acid (HA), cell adhesive peptides (RGD), transforming growth factor β3, dexamethasone are biological agents potentially suitable for chondrogenic stimulation of hMSCS. However unmodified HA suffers of drawbacks in terms of stability and versatility of processing. Functionalization strategies…

Hyaluronic acid and alpha-elastin based hydrogel for three dimensional culture of vascular endothelial cells

2018

Abstract The aim of this work was to demonstrate that employing a copolymer of hyaluronic acid and α-elastin (HA-EDA-g-α-elastin) is possible to produce a scaffold able to support the adhesion and growth of human vascular endothelial cells (HUVEC) thanks to its ability to incorporate and control the diffusion of vascular endothelial growth factor (VEGF). HA-EDA-g-α-elastin was crosslinked with low molecular weight hyaluronic acid (HALMW) to obtain a hydrogel that gives rise to the formation of three dimensional sponge after the freeze drying process. The physicochemical features the obtained material along with its ability to act as a support for the three dimensional culture of endothelial…

From job demands and resources to work engagement, burnout, life satisfaction, depressive symptoms, and occupational health

2016

This study investigated the cross-lagged associations between work engagement and burnout, and life satisfaction and depressive symptoms, their demands (i.e., workload) and resources (i.e., servant leadership, self-efficacy, resilience) and relationships with occupational health outcomes (i.e., recovery, number of mental health diagnoses, workaholism). This study is a part of an ongoing Occupational Health Study in which 1 415 employees (586 men, 829 women) were followed twice during two years 2011–12 through their occupational health services. The participants filled in a questionnaire on their work engagement, burnout symptoms, well-being, personal and work environmental resources and dem…

”Hyvät käytännöt ovat hyviä iästä riippumatta!”

2012

Näyttää siltä, että työmarkkinajärjestöjen aktiivinen ikäpolitiikka on keskittynyt lähinnä eläkepolitiikkaa koskeviin kysymyksiin. Vaikka koulutukseen, osaamiseen ja urakehitykseen liittyvä elinikäisen oppimisen politiikka on työmarkkinajärjestöjen toiminnassa myös keskeisesti läsnä, on se tapahtunut ikäpolitiikasta erillään. – Older Workers in the Nordic Countries (OWN) -verkoston toimesta toteutettiin 2009-2010 välisenä aikana kyselytutkimus viidessä pohjoismaassa, jossa selviteltiin työmarkkinajärjestöjen ikääntyviä työntekijöitä koskevaa politiikkaa ja käytäntöjä.

Are Intercultural Competences at the Center of Job-Market Demands ?

2020

International audience; This chapter introduces the theoretical framework upon which this study was based before going on to set out the methodology used and detail the main results found. It discusses results in the light of scientific literature on the issue and their managerial implications. With the internationalization of organizational structures, the development of intercultural competences was often considered a strategic benefit. Indeed, companies are sensitive to the cultural diversity of their worldwide branches and to the international competences developed by their employees. Through organizational internationalization, intercultural competences become strategic resources. Alth…

The 2017 PREDICT Key Facts Report: An Analysis of ICT R&D in the EU

2017

The 2017 PREDICT Key Facts Report provides a detailed analysis of the state of ICT R&D activities in the European Union. This is the tenth edition of a series that is published annually. Like the previous editions, an online version is available at: https://ec.europa.eu/jrc/en/predict. The PREDICT dataset 2017 is based on the latest data available from official sources (such as the Eurostat and OECD, National Accounts and R&D statistics). It also includes the novelty of backwards reconstruction of the series from 1995, which allows it to cover the period from 1995 to 2014. Therefore, it provides a long-term analysis of the EU ICT sector and its R&D, covering a whole cycle since the initial …