Search results for " hyperactivity"
showing 10 items of 230 documents
Prospective relationships of ADHD symptoms with developing substance use in a population-derived sample
2011
BackgroundClinically ascertained reports suggest that boys and girls with attention deficit hyperactivity disorder (ADHD) may differ from each other in their vulnerability to substance use problems.MethodA total of 1545 Finnish adolescents were assessed for DSM-IV-based ADHD symptoms by their parents and classroom teachers using standardized rating scales at age 11–12 years. At age 14, substance use disorders and psychiatric co-morbidity were assessed with the Semi-Structured Assessment for the Genetics of Alcoholism, providing DSM-III-R/DSM-IV diagnoses for Axis I disorders. At age 17.5, substance use was assessed by multi-item questionnaire.ResultsAlthough baseline ADHD symptoms were less…
Meta-analysis of genome-wide association studies of attention-deficit/hyperactivity disorder
2010
Contains fulltext : 87688.pdf (Publisher’s version ) (Closed access) OBJECTIVE: Although twin and family studies have shown attention-deficit/hyperactivity disorder (ADHD) to be highly heritable, genetic variants influencing the trait at a genome-wide significant level have yet to be identified. As prior genome-wide association studies (GWAS) have not yielded significant results, we conducted a meta-analysis of existing studies to boost statistical power. METHOD: We used data from four projects: a) the Children's Hospital of Philadelphia (CHOP); b) phase I of the International Multicenter ADHD Genetics project (IMAGE); c) phase II of IMAGE (IMAGE II); and d) the Pfizer-funded study from the…
Corpus Callosum Morphology in Attention Deficit-Hyperactivity Disorder: Morphometric Analysis of MRI
1991
Although behavioral evidence provides support for the notion that attention deficit-hyperactivity disorder (ADHD) is related to central nervous system dysfunction, there is little direct evidence to reveal which neurometabolic systems or brain structures are involved. Recent magnetic resonance imaging (MRI) studies suggest that, compared to nondisabled controls, ADHD children may have a smaller right frontal region. Morphometric analysis of MRI scans was used in this exploratory study to determine whether correlated regional variation might exist in the corpus callosum of children with ADHD. While all MRI scans were judged to be clinically normal, morphometric analysis revealed that, compa…
Comorbidity between obesity and attention deficit/hyperactivity disorder: Population study with 13–15-year-olds
2006
Objective: This study analyzes whether obese children have a higher risk of attention deficit/hyperactivity “characteristics” (AD/HD) than do children with other nutritional states. Method: This study included 35,403 participants from 486 community schools. They completed the AD/HD scale of the Strengths and Difficulties Questionnaire (SDQ) and were weighed and measured. 2879 of the participants were obese and 78 were morbidly obese (BMI >40). Results: A discrete, nonsignificant, increment was found in the AD/HD characteristics of male participants with morbid obesity, as compared with the other nutritional states. Among morbidly obese females, the prevalence of AD/HD characteristics was sl…
Does mismatch negativity show differences in reading-disabled children compared to normal children and children with attention deficit?
2007
An auditory event-related potential (ERP) component called mismatch negativity (MMN) was examined in three groups of children (n = 63) aged 8-14 years. A control group comprised healthy children in second or sixth grade of comprehensive school (n = 21). The two clinical groups included children with reading disability (RD) (n = 21) and children with attention deficit (AD) (n = 21). MMN was elicited in a passive oddball paradigm by duration changes in a continuous sound, consisting of two alternating (600 and 800 Hz) 100 msec tones. The deviant tones were either 30 or 50 msec in duration. Both deviants elicited a clear MMN in all groups. Statistical analyses showed no systematic difference i…
Mismatch negativity (MMN) elicited by duration deviations in children with reading disorder, attention deficit or both.
2007
According to several studies auditory discrimination as measured by mismatch negativity (MMN) is compromised in participants with reading disorder. However, studies on duration discrimination have produced conflicting findings [Baldeweg, T., Richardson, A., Watkins, S., Foale, C., & Gruzelier, J., 1999. Impaired auditory frequency discrimination in dyslexia detected with mismatch evoked potentials. Annals of Neurology, 4, 1-9; Corbera, S., Escera, C., & Artigas, J., 2006. Impaired duration mismatch negativity in developmental dyslexia. Neuroreport, 17, 1051-1055]. Auditory sensitivity has not been as actively investigated among children with attention deficit, although attention problems of…
Amusia and Cognitive Deficits after Stroke
2009
We studied the relationship between musical and cognitive deficits by testing middle cerebral arterial (MCA) stroke patients (n= 53) with a shortened version of the Montreal Battery of Evaluation of Amusia (MBEA) and an extensive neuropsychological test battery. Results showed that amusic patients (n= 32) had more severe cognitive deficits, especially in working memory and executive functioning, than did non-amusic patients (n= 21), and the severity of amusia also correlated with attention deficits. These findings thus suggest that domain-general attention, executive, and working memory processes are associated with amusia after stroke.
Association between breastfeeding duration and cognitive development, autistic traits and ADHD symptoms: a multicenter study in Spain
2017
BACKGROUND: Several studies have related longer breastfeeding duration to better intellectual performance in children. By contrast, few studies have investigated the potential protective effects of breastfeeding against behavioral problems such as attention deficit hyperactivity disorder (ADHD) symptoms, and even fewer on autism spectrum disorders (ASD) traits. METHODS: We examined the association between breastfeeding duration and cognitive development, attention, ADHD symptoms, and autistic traits using data from the INMA Project, a Spanish multicenter birth-cohort study, and taking into account the intensity of breastfeeding. Duration of any, predominant, and exclusive breastfeeding was …
Differential effects of bupropion on acquisition and performance of an active avoidance task in male mice.
2015
Bupropion is an antidepressant drug that is known to aid smoking cessation, although little experimental evidence exists about its actions on active avoidance learning tasks. Our aim was to evaluate the effects of this drug on two-way active avoidance conditioning. In this study, NMRI mice received bupropion (10, 20 and 40mg/kg) or saline before a daily training session (learning phase, days 1-4) in the active avoidance task. Performance was evaluated on the fifth day (retention phase): in each bupropion-treated group half of the mice continued with the same dose of bupropion, and the other half received saline. Among the vehicle-treated mice, different sub-groups were challenged with diffe…
DSM-IV Combined Type ADHD Shows Familial Association With Sibling Trait Scores
2008
Contains fulltext : 69060.pdf (Publisher’s version ) (Closed access) Attention deficit hyperactivity disorder (ADHD) is a discrete clinical syndrome characterized by the triad of inattention, hyperactivity, and impulsivity in the context of marked impairments. Molecular genetic studies have been successful in identifying genetic variants associated with ADHD, particularly with DSM-IV inattentive and combined subtypes. Quantitative trait locus (QTL) approaches to linkage and association mapping have yet to be widely used in ADHD research, although twin studies investigating individual differences suggest that genetic liability for ADHD is continuously distributed throughout the population, u…