Search results for " import"

showing 10 items of 163 documents

Prioritisation of alternatives with analytical hierarchy process plus response latency and web surveys

2014

This paper introduces a new method that combines the well-known analytical hierarchy process (AHP) with a response latency metric. The response latency is the time taken by respondents to make choices over pairwise comparisons. The analytical calculation of relative importance weights of the alternatives is made by using a response latency model previously validated in several case studies. This combination aims to overcome some drawbacks of the traditional AHP related to the use of a rating scale (the so-called Saaty scale), and it is a natural way to involve response latency in established decisionmaking methods. This new method can be profitably adopted in web surveys where it is easy to…

Settore SECS-S/02 - Statistica Per La Ricerca Sperimentale E Tecnologicabusiness.industryComputer scienceattribute ratingAnalytic hierarchy processrelative importance weightweb surveysMachine learningcomputer.software_genreGeneral Business Management and Accountingresponse latencyanalytical hierarchy proceRating scaleRespondentEconometricspairwise comparisonPairwise comparisonArtificial intelligenceLatency (engineering)New service developmentbusinesscomputerprioritisationTotal Quality Management & Business Excellence
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Benralizumab Effectiveness in Severe Eosinophilic Asthma with and without Chronic Rhinosinusitis with Nasal Polyps: A Real-World Multicenter Study

2021

Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) affects around 60% of patients with severe eosinophilic asthma (SEA). Benralizumab was recently approved for SEA add-on treatment. Objective: To assess the real-world effectiveness of benralizumab in SEA with or without CRSwNP. Methods: We conducted a multicenter observational study, including patients with SEA treated with benralizumab for 24 weeks in 12 Italian specialized facilities. Asthma exacerbations, Asthma Control Test (ACT), lung function, oral corticosteroid (OCS) dosage, and eosinophil and basophil count in peripheral blood were recorded at baseline and after 4, 12, and 24 weeks. The 22-item Sino-Nasal Outcome Test (S…

Severe asthmaVital capacitymedicine.medical_specialtymedicine.drug_classSettore MED/10 - Malattie Dell'Apparato RespiratorioAntibodies Monoclonal HumanizedFEV1/FVC ratiochemistry.chemical_compoundNasal PolypsInternal medicinemedicineHumansImmunology and AllergyNasal polypsAnti-Asthmatic AgentsIL-5Nasal polypbusiness.industryMinimal clinically important differenceBenralizumabFunctional endoscopic sinus surgeryrespiratory systemEosinophilBenralizumabmedicine.diseaseAsthmaChronic rhinosinusitismedicine.anatomical_structureReal-worldchemistryChronic rhinosinusitiCorticosteroidbusinessHumanThe Journal of Allergy and Clinical Immunology: In Practice
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Binding Sites, Vibrations and Spin-Lattice Relaxation Times in Europium(II)-Based Metallofullerene Spin Qubits.

2021

Abstract To design molecular spin qubits with enhanced quantum coherence, a control of the coupling between the local vibrations and the spin states is crucial, which could be realized in principle by engineering molecular structures via coordination chemistry. To this end, understanding the underlying structural factors that govern the spin relaxation is a central topic. Here, we report the investigation of the spin dynamics in a series of chemically designed europium(II)‐based endohedral metallofullerenes (EMFs). By introducing a unique structural difference, i. e. metal‐cage binding site, while keeping other molecular parameters constant between different complexes, these manifest the ke…

Spin statesFOS: Physical scienceschemistry.chemical_element010402 general chemistry01 natural sciencesMolecular physicsCatalysischemistry.chemical_compoundVery Important PaperPhysics - Chemical PhysicsPhysics::Atomic and Molecular ClustersPhysics - Atomic and Molecular Clustersspin-vibration couplingQuantumeuropiumSpin-½Chemical Physics (physics.chem-ph)Full Paper010405 organic chemistryChemistryNanotecnologiaOrganic ChemistryRelaxation (NMR)Spin–lattice relaxationfullerenesGeneral ChemistryQuímicaFull Papers0104 chemical sciences3. Good healthQubitMetallofullerenemagnetic propertiesAtomic and Molecular Clusters (physics.atm-clus)Europiumspin qubitsChemistry (Weinheim an der Bergstrasse, Germany)
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Assessing the quality of studies in meta-research: Review/guidelines on the most important quality assessment tools

2020

Systematic reviews and meta-analyses pool data from individual studies to generate a higher level of evidence to be evaluated by guidelines. These reviews ultimately guide clinicians and stakeholders in health-related decisions. However, the informativeness and quality of evidence synthesis inherently depend on the quality of what has been pooled into meta-research projects. Moreover, beyond the quality of included individual studies, only a methodologically correct process, in relation to systematic reviews and meta-analyses themselves, can produce a reliable and valid evidence synthesis. Hence, quality of meta-research projects also affects evidence synthesis reliability. In this overview…

Statistics and ProbabilityCONSORTmedia_common.quotation_subjectPRISMAmeta-researchStrengthening the reporting of observational studies in epidemiology01 natural sciencesAMSTAR-PLUS; AMSTAR2; CONSORT; Cochrane; NOS; PRISMA; STROBE; meta-analysis; meta-research; quality010104 statistics & probability03 medical and health sciences0302 clinical medicineAMSTAR-PLUSBiasSTROBEMedicineHumansPharmacology (medical)Quality (business)AMSTAR2 AMSTAR-PLUS Cochrane CONSORT meta-analysis meta-research NOSPRISMA quality STROBE030212 general & internal medicine0101 mathematicsmedia_commonPharmacologyReview/guidelines on the most important quality assessment tools- PHARMACEUTICAL STATISTICS 2020 [Luchini C. Veronese N. Nottegar A. Shin J. I. Gentile G. Granziol U. SOYSAL P. Alexinschi O. Smith L. Solmi M. -Assessing the quality of studies in meta-research]business.industryConsolidated Standards of Reporting TrialsReproducibility of ResultsEvidence-based medicineNOSJadad scaleAMSTAR2meta-analysisSystematic reviewCochraneRisk analysis (engineering)AMSTAR-PLUS; AMSTAR2; Cochrane; CONSORT; meta-analysis; meta-research; NOS; PRISMA; quality; STROBEqualityResearch DesignMeta-analysisObservational studybusiness
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Translocation Biosensors – Cellular System Integrators to Dissect CRM1-Dependent Nuclear Export by Chemicogenomics

2009

Fluorescent protein biosensors are powerful cellular systems biology tools for dissecting the complexity of cellular processes with high spatial and temporal resolution. As regulated nucleo-cytoplasmic transport is crucial for the modulation of numerous (patho)physiological cellular responses, a detailed understanding of its molecular mechanism would open up novel options for a rational manipulation of the cell. In contrast to genetic approaches, we here established and employed high-content cellular translocation biosensors applicable for dissecting nuclear export by chemicogenomics. A431 cell lines, stably expressing a translocation biosensor composed of glutathione S-transferase, GFP and…

Systems biologyChemical biologyNanotechnologychemical biologyComputational biologyBiologylcsh:Chemical technologyBiochemistryArticleAnalytical ChemistryGreen fluorescent proteinFlow cytometrychemical biology; cancer; Exportin 1/CRM1; HIV-1 Rev; import; LMB; nucleocytoplasmic transport; nucleoporinimportmedicinecancerlcsh:TP1-1185Electrical and Electronic EngineeringNuclear export signalLMBInstrumentationExportin 1/CRM1HIV-1 Revnucleocytoplasmic transportmedicine.diagnostic_testnucleoporinAtomic and Molecular Physics and OpticsChemical spacecancer ; HIV-1 Rev ; import ; nucleocytoplasmic transport ; LMB ; chemical biology ; Exportin 1/CRM1 ; nucleoporinNucleoporinNuclear transportBiologieSensors
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Response to Skeide and Friederici: The myth of the uniquely human “direct” dorsal pathway

2015

In their comment on our recent article [1], Skeide and Friederici [2] claim ‘that some important data not discussed by Bornkessel-Schlesewsky et al. strongly support the view that there are clear qualitative, and not merely quantitative, differences between [human and nonhuman primate] species with respect to both the intrinsic functional connectivity of frontal and temporal cortices, and their direct structural connection via a dorsal white matter fiber tract.’ This obviously refers to work by Friederici and colleagues [3] emphasizing the functional importance of a direct connection between the posterior superior temporal cortex (pSTC) and Brodmann area (BA) 44 in humans, and its absence i…

Temporal cortexDorsumPrimatesCognitive NeuroscienceFunctional connectivityletterBrainExperimental and Cognitive PsychologyNonhuman primateArticleNeuropsychology and Physiological PsychologyFunctional importanceAuditory PerceptionAnimalsHumansPsychologyNeuroscienceTemporal CorticesBrodmann areaLanguage
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La scoperta, sistemazione e conservazione della grande Iscrizione di Gortina, nell'isola di Creta (1884-1921): la protezione delle testimonianze e le…

2013

La scoperta e la conservazione della Grande Iscrizione di Gortina a Creta, da parte degli studiosi italiani, fra la fine del XIX sec. e i primi decenni del XX sec., rappresentò un grande riconoscimento scientifico-culturale per la giovane nazione italiana. Nel passato, l’isola di Creta era stata legata alla Repubblica di Venezia e anche questo rapporto favorì l’invio a Creta del giovane epigrafista F. Halbherr, il quale fra notevoli peripezie rinvenne, assieme all’epigrafista tedesco E. Fabricius, la famosa l’iscrizione nell’antica città di Gortina. L’iscrizione, fra le più antiche e complete finora conosciute in tutta Europa, conteneva le norme sulla famiglia, l’eredità e in generale i dir…

The discovery and preservation of the Great Inscription of Gortyna in Crete by Italian researchers in the late nineteenth century. and the first decades of the twentieth century. was an important cultural and scientific recognition for the young Italian nation. In the past the island of Crete had been tied to the Republic of Venice and this report also favored sending in Crete the young epigraphist F. Halbherr who among considerable vicissitudes came to together to the epigraphist german E. Fabricius the inclusion of the famous ancient city of Gortyna. The inscription among the oldest and most comprehensive so far known throughout Europe the rules contained on the family's legacy in general and the rights and duties of some of the people of the Minoan civilization (480-450 BC). The inscription was carved on blocks organic limestone a restored ancient building which later in Roman times was turned into odeon. The Laws of Gortyn were engraved on the remains of the wall forming the passageway in front of the steps of the odeon. The essay traces the events that led to the discovery and subsequent storage made by Halbherr especially with the help of archaeologist L. Pernier and finally with the help of architect E. Stefani who designed a modern cover on the top of the ambulatory of the segments containing the inscription. This coverage was made to perform during the First World War on the basis of the Italian project from the Greek Government in order to protect the membership from possible war damage but especially from vandalism. The roof brick clay of the Laws of Gortyna still serves its function and ensures the use of the monument bearing witness to the preservation of Italian culture in Greece and more generally in the world. But in Sicily in the remains of the Villa del Casale in Piazza Armerina (Enna) its elegant protection (built in 1957) is representative of a whole period of culture of the Italian restoration is removed and replaced because it has not been able to make a ongoing maintenance is due. A bad example of conservation and management of a UNESCO monument from which arise after the work for the construction of new roofs an equally insulting to the archaeological heritage and scenic Italian and world.Settore ICAR/19 - Restauro
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Tutela e sicurezza del lavoro tra centro e periferia: la sicurezza sui luoghi di lavoro

2013

Il saggio prende in esame la complessa questione del riparto di competenze tra Stato e Regioni alla luce del Titolo V della Costituzione in materia di salute e sicurezza sui luoghi di lavoro. Il riparto di competenze tra centro e periferia è stato oggetto di una limitata analisi da parte della dottrina e della giurisprudenza, che si sono concentrate in particolare sulla disciplina del mercato del lavoro. L’Autore descrive un sistema multilivello, caratterizzato dalla compresenza di fonti nazionali e regionali, della contrattazione collettiva, nonché di codici di condotta. Sulla scorta di una ricostruzione del quadro normativo e dei percorsi della giurisprudenza, il saggio propone una lettur…

The essay examines the complex issue of the division of powers between the State and the Regions according to Title V of the Constitution concerning health and safety at workplace. This division between the center and the periphery has been subject to a limited review by doctrine and jurisprudence expecially focusing on the regulation of labour market. The Author describes a multilevel system characterized by the presence of national and regional sources collective bargaining and codes of conduct. On the basis of a reconstruction of the regulatory framework and the judicial statements the paper proposes a dynamic reading of the relationship between center and periphery in which the axis of the system remains however anchored to the national jurisdiction along with important regulatory issues left to the regional legislation.Settore IUS/07 - Diritto Del Lavoro
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I feudi a masserie nell'arcivescovato di Monreale. Un esempio di organizzazione economica del territorio (secc. XV-XVII)

2022

Il saggio indaga "i feudi a masserie", uno dei segmenti economici e giuridici più importanti del territorio dell'arcivescovato di Monreale.

The essay investigates "the fiefdoms and farms" one of the most important economic and legal segments of the territory of the archbishopric of Monreale.Settore M-STO/02 - Storia Moderna
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L'ecomuseo del grano e del pane: un percorso progettuale centrato sul design

2018

La festa di S. Giuseppe, oltre che un’importante e sentita ricorrenza religiosa, è a Salemi soprattutto la “festa dei pani”; bellissime realizzazioni di alto artigianato artistico, la cui sapienza si tramanda nelle famiglie e nelle associazioni di donne che per mesi lavorano alla produzione dell’enorme quantità delle piccole e grandi forme di pane, per rivestire le costruzioni votive che accolgono il rito della cena. Nasce quindi l’idea di proporre un “Ecomuseo del grano e del pane” nel Collegio dei Gesuiti, valorizzando e riaprendo al pubblico uno spazio di grande interesse storico-architettonico. Nell’ambito della consolidata collaborazione del Comune di Salemi con il Dipartimento di Arch…

The feast of St. Joseph as well as an important and heartfelt religious celebration is in Salemi above all the "feast of the loaves"beautiful achievements of high artistic craftsmanship whose wisdom is handed down in the families and in the associations of women who for many months work to produce the enormous quantity of small and large forms of bread to cover the votive constructions that welcome the ritual of dinner.Thus the idea of proposing an "Ecomuseum of wheat and bread" in the Jesuit College was born enhancing and re-opening a space of great historical-architectural interest to the public. As part of the consolidated collaboration of the Municipality of Salemi with the Department of Architecture professors and students worked on a strategic design project for museum set-up and communication also open forms of participation and sharing with the various territorial actors in a sort of 'social conversation' with the protagonists and skills in the field. A collaboration with Polimi Desis_Lab of the Milan Polytechnic concerning the contribution of the 'design of services for social innovation' was also initiated on these aspects.Settore ICAR/13 - Disegno Industriale
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