Search results for " infiltration"
showing 10 items of 104 documents
Loss of cellular FLICE-inhibitory protein promotes acute cholestatic liver injury and inflammation from bile duct ligation.
2017
Cholestatic liver injury results from impaired bile flow or metabolism and promotes hepatic inflammation and fibrogenesis. Toxic bile acids that accumulate in cholestasis induce apoptosis and contribute to early cholestatic liver injury, which is amplified by accompanying inflammation. The aim of the current study was to evaluate the role of the antiapoptotic caspase 8-homolog cellular FLICE-inhibitory (cFLIP) protein during acute cholestatic liver injury. Transgenic mice exhibiting hepatocyte-specific deletion of cFLIP (cFLIP−/−) were used for in vivo and in vitro analysis of cholestatic liver injury using bile duct ligation (BDL) and the addition of bile acids ex vivo. Loss of cFLIP in h…
Changes in soil hydrodynamic parameters during intermittent rainfall following tillage
2023
The changes in the soil hydrodynamic properties following soil tillage were investigated in rainfall simulation trials of intermittent rain at the Masse experimental station (Soil Erosion LABoratory, SERLAB) in central Italy. The experiments were designed to build a database as representative as possible of situations that may occur in nature. The data collected during the experiments were used to determine the saturated soil hydraulic conductivity, Ks, the soil sorptivity at the antecedent soil–water matric potential Ψi, S, and the flow-weighted mean pore size at Ψi, λm. It was also verified if the energy content of total rainfall after tillage explained the short-term temporal variability…
Lipoic acid lessens Th1-mediated inflammation in lipopolysaccharide-induced uveitis reducing selectively Th1 lymphocytes-related cytokines release
2013
AbstractInflammation results in the production of free radicals. We evaluated the anti-inflammatory and antioxidant capacity of lipoic acid in an experimental uveitis model upon a subcutaneous injection of endotoxin into Lewis rats. The role of oxidative stress in the endotoxin-induced uveitis model is well-known. Besides, the Th1 response classically performs a central part in the immunopathological process of experimental autoimmune uveitis. Exogenous sources of lipoic acid have been shown to exhibit antioxidant and anti-inflammatory properties. Our results show that lipoic acid treatment plays a preventive role in endotoxin-induced oxidative stress at 24 h post-administration and reduced…
Laboratory testing of Beerkan infiltration experiments for assessing the role of soil sealing on water infiltration
2018
Abstract Soil surface sealing is a major cause of decreased infiltration rates and increased surface runoff and erosion during a rainstorm. The objective of this paper is to quantify the effect of surface sealing on infiltration for 3 layered soils with different textures for the upper layer and investigate the capability of BEST procedure to catch the formation of the seal and related consequences on water infiltration. Rainfall experiments were carried out to induce the formation of the seal. Meanwhile, Beerkan infiltration runs were carried out pouring water at different distances from the soil surface (BEST-H versus BEST-L runs, with a High and Low water pouring heights, respectively) f…
Las crecidas en ramblas valencianas mediterráneas
2001
This paper takes into account the characterisation of ephemeral stream hydrology from Mediterranean environments. The heavy floods that these countries suffer are due to firstly, the physical watershed features (steep slopes, scarced vegetation cover and thin soils) and, secondly, to the intense and variable rainfall. Large quantities of precipitation fall in a matter of hours, or even minutes, over very steep catchments, causing catastrophic flash-floods, with very pointed hydrographs and short time lags. Using hydrological daily data from the Rambla de la Viuda basin and five-minute data from both Barranc de Carraixet and Rambla de Poyo basins, we have analysed the rainfall- runoff proces…
Estimating the macroscopic capillary length from Beerkan infiltration experiments and its impact on saturated soil hydraulic conductivity predictions
2020
International audience; The macroscopic capillary length, λc, is a fundamental soil parameter expressing the relative importance of the capillary over gravity forces during water movement in unsaturated soil. In this investigation, we propose a simple field method for estimating λc using only a single-ring infiltration experiment of the Beerkan type and measurements of initial and saturated soil water contents. We assumed that the intercept of the linear regression fitted to the steady-state portion of the experimental infiltration curve could be used as a reliable predictor of λc. This hypothesis was validated by assessing the proposed calculation approach using both analytical and field d…
Chronic obstructive pulmonary disease and neutrophil infiltration: role of cigarette smoke and cyclooxygenase products.
2010
Cigarette smoke is the main cause of chronic obstructive pulmonary disease (COPD), where it can contribute to the observed airway inflammation. PGE(2) is produced within human airways, and both pro- and anti-inflammatory activities have been reported. We quantitated PGE(2) concentrations in induced sputum supernatants from different groups of subjects and correlated the obtained values to neutrophil infiltration as well as to the expression of cyclooxygenase-2 (COX-2). Cigarette smoke extract (CSE) was used to evaluate the effect of smoking on COX-2 and PGE(2) receptor expression as well as on PGE(2) release in neutrophils and alveolar macrophages (AM) obtained from normal donors. The effec…
Using Beerkan experiments to estimate hydraulic conductivity of a crusted loamy soil in a Mediterranean vineyard
2019
Abstract In bare soils of semi-arid areas, surface crusting is a rather common phenomenon due to the impact of raindrops. Water infiltration measurements under ponding conditions are becoming largely applied techniques for an approximate characterization of crusted soils. In this study, the impact of crusting on soil hydraulic conductivity was assessed in a Mediterranean vineyard (western Sicily, Italy) under conventional tillage. The BEST (Beerkan Estimation of Soil Transfer parameters) algorithm was applied to the infiltration data to obtain the hydraulic conductivity of crusted and uncrusted soils. Soil hydraulic conductivity was found to vary during the year and also spatially (i.e., ro…
Urban Storm-Water Quality Management: Centralized versus Source Control
2010
The continuous growth of urban areas and the increasing public awareness of the environmental impacts of storm water have raised interest on the quality of the receiving water bodies. In the past two decades, many efforts have been directed at improving urban drainage systems by introducing mitigation measures to limit the negative environmental impacts of storm water. These mitigation measures are generally called best management practices (BMPs), sustainable urban drainage systems, or low impact developments, and they include practices such as infiltration and storage tanks that reduce the peak flow and retain some of the polluting materials. Choosing the best mitigation measure is still …
Comparing two methods to perform a beerkan infiltration run in a loam soil at different dates
2023
<p>Performing beerkan infiltration runs with different heights of water pouring could help to obtain saturated soil sorptivity, <em>S</em>, and hydraulic conductivity, <em>K<sub>s</sub></em>, data usable to explain and simulate hydrological processes. However, most of the available information on the L (low height of water pouring, nearly 3 cm) - H (high height, 1-2 m) methodology refers to runs making use of a relatively limited number of water volumes and there is some sign that a few water volumes could yield an incomplete description of soil alteration phenomena induced by wetting. For a lo…