Search results for " integrity"
showing 10 items of 126 documents
Lung fixation for the preservation of air spaces.
2004
The procedures for the fixation of entire lungs of small rodents are presented together with various techniques used to verify the structural integrity of the lung tissue. To achieve this, the lungs were dissected out from rats and mice killed by ether overdose. The specimens were rinsed with isotonic saline and fixation solution under low vacuum conditions. After fixation, they were dried using alcohol and stored in a noncollapsed state (i.e., state of inhalation). Light and scanning electron microscopy as well as magnetic resonance imaging using hyperpolarized 3He were employed to verify the intact state on interalveolar septa and walls of smaller bronchi as well as accessibility of the a…
La percepción de amenaza física en la pareja y el bienestar en la juventud
2021
El presente trabajo estudia la percepción de amenaza hacia la seguridad y/o integridad física en las relaciones de pareja durante la juventud en relación con variables del bienestar personal y de pareja en la actualidad. Participaron 316 jóvenes entre 18 y 36 años (M=23.61; DT=3.678), 72.47% se identificaron con el género femenino. Respecto a la orientación sexual, 64.87% fueron heterosexuales y 35.12% de otras orientaciones sexuales. Se evaluó la percepción de amenaza física en la pareja actual y relaciones pasadas (preguntas ad hoc), el bienestar con la pareja actual (SWRS), la satisfacción con la relación (RAS) y el bienestar subjetivo (SWLS y SPANE). La recogida de datos se realizó onli…
DICER and ZRF1 contribute to chromatin decondensation during nucleotide excision repair
2016
Abstract Repair of damaged DNA relies on the recruitment of DNA repair factors in a well orchestrated manner. As a prerequisite, the chromatin needs to be decondensed by chromatin remodelers to allow for binding of repair factors and for DNA repair to occur. Recent studies have implicated members of the SWI/SNF and INO80 families as well as PARP1 in nucleotide excision repair (NER). In this study, we report that the endonuclease DICER is implicated in chromatin decondensation during NER. In response to UV irradiation, DICER is recruited to chromatin in a ZRF1-mediated manner. The H2A–ubiquitin binding protein ZRF1 and DICER together impact on the chromatin conformation via PARP1. Moreover, …
The telomeric Cdc13-Stn1-Ten1 complex regulates RNA polymerase II transcription
2019
Advance article.
An Approach to Data Quality Evaluation
2018
This research proposes a new approach to data quality evaluation comprising 3 aspects: (1) data object definition, which quality will be analyzed, (2) quality requirements specification for the data object using Domain Specific Language (DSL), (3) implementation of an executable data quality model that would enable scanning of data object and detect its shortages. Like the Model Driven Architecture (MDA) the data quality modelling is divided into platform independent (PIM) and platform-specific (PSM) models. PIM comprises informal specifications of data quality, PSM describes implementation of data quality model, thus making the data quality model executable. The approbation of the proposed…
Protein kinase C controls activation of the DNA integrity checkpoint
2014
The protein kinase C (PKC) superfamily plays key regulatory roles in numerous cellular processes. Saccharomyces cerevisiae contains a single PKC, Pkc1, whose main function is cell wall integrity maintenance. In this work, we connect the Pkc1 protein to the maintenance of genome integrity in response to genotoxic stresses. Pkc1 and its kinase activity are necessary for the phosphorylation of checkpoint kinase Rad53, histone H2A and Xrs2 protein after deoxyribonucleic acid (DNA) damage, indicating that Pkc1 is required for activation of checkpoint kinases Mec1 and Tel1. Furthermore, Pkc1 electrophoretic mobility is delayed after inducing DNA damage, which reflects that Pkc1 is post-translatio…
Efficient and Lightweight Data Integrity Check in In-Networking Storage Wireless Sensor Networks
2009
In In-networking storage Wireless Sensor Networks, sensed data are stored locally for a long term and retrieved on-demand instead of real-time. To maximize data survival, the sensed data are normally distributively stored at multiple nearby nodes. It arises a problem that how to check and grantee data integrity of distributed data storage in the context of resource constraints. In this paper, a technique called Two Granularity Linear Code (TGLC) that consists of Intra-codes and Inter-codes is presented. An efficient and lightweight data integrity check scheme based on TGLC is proposed. Data integrity can be checked by any one who holds short Inter-codes, and the checking credentials is shor…
Ethics appraisal procedure in 79,670 Marie Skłodowska-Curie proposals from the entire European HORIZON 2020 research and innovation program (2014–202…
2021
Introduction Horizon 2020 was the most significant EU Research and Innovation programme ever implemented and included the Marie Skłodowska-Curie Actions (MSCA). Proposals submitted to the MSCA actions awere subject to the Ethics Appraisal Procedure. In this work we explored the ethics appraisal procedure in MSCA H2020. Methods Using a retrospective analysis of pooled anonymized data, we explored the ethics appraisal procedure on proposals submitted to Marie Skłodowska-Curie Actions (MSCA) during the entire Horizon 2020 program period (N = 79,670). Results Our results showed that one of the most frequently identified ethics categories was Data protection. We also detected slight differences…
Effects of the Best Possible Self intervention: A systematic review and meta-analysis
2019
The Best Possible Self (BPS) exercise promotes a positive view of oneself in the best possible future, after working hard towards it. Since the first work that attempted to examine the benefits of this intervention in 2001, studies on the BPS have grown exponentially and, currently, this is one of the most widely used Positive Psychology Interventions. However, little is yet known about its overall effectiveness in increasing wellbeing outcomes. Thus, the aim of this meta-analysis is to shed light on this question. A systematic literature search was conducted, and 29 studies (in 26 articles) met the inclusion criteria of empirically testing the intervention and comparing it to a control con…
El plagio y las revistas depredadoras como amenaza a la integridad cientifica
2019
Resumen: Este artículo propone un análisis del concepto del plagio con la finalidad de mostrar el amplio espectro de manifestaciones que pueden ser consideradas como tal al incurrir en una transgresión de la propiedad intelectual, realizada con el ánimo de engañar sobre la verdadera contribución de los autores y sobre la originalidad y novedad de la información.Describe las distintas circunstancias en las que se incurre en un plagio intencional y el daño que esta mala conducta ocasiona en la credibilidad de un sistema científico, en el que el crédito de autoría es el fundamento de la carrera académica, del prestigio del autor en la comunidad científica y la base para la financiación de la i…