Search results for " investigation"

showing 10 items of 289 documents

Conquests and perspectives of cardio-oncology in the field of tumor angiogenesis-targeting tyrosine kinase inhibitor-based therapy

2015

Abstract: Introduction: Angiogenesis is fundamental for tumor development and progression. Hence, anti-angiogenic drugs have been developed to target VEGF and its receptors (VEGFRs). Several tyrosine kinase inhibitors (TKIs) have been developed over the years and others are still under investigation, each anti-VEGFR TKI showing a different cardiotoxic profile. Knowledge of the cardiac side-effects of each drug and the magnitude of their expression and frequency can lead to a specific approach. Areas covered: This work reviews the mechanism of action of anti-VEGFR TKIs and the pathophysiological mechanisms leading to cardiotoxicity, followed by close examination of the most important drugs i…

SorafenibOncologymedicine.medical_specialtymedicine.drug_classSettore MED/06 - Oncologia MedicaAntineoplastic AgentsPharmacologyVandetanibModels BiologicalTyrosine-kinase inhibitorPazopanibchemistry.chemical_compoundInternal medicineRegorafenibNeoplasmsmedicineHumansPharmacology (medical)Molecular Targeted TherapyProtein Kinase Inhibitorstyrosine kinase inhibitor cardiac toxicityNeovascularization PathologicSunitinibbusiness.industryPharmacology. TherapyCancerHeartGeneral MedicineDrugs InvestigationalProtein-Tyrosine Kinasesmedicine.diseaseAxitinibReceptors Vascular Endothelial Growth FactorchemistryCardiovascular Diseasesbusinessmedicine.drug
researchProduct

La Valle dei Templi in epoca medioevale. Caratterizzazione antropologica e paleopatologica delle sepolture antistanti in Tempio della Concordia

2021

Riassunto ― Il lavoro presenta i risultati delle analisi bio-archeologiche effettuate su resti scheletrici umani rinvenuti in quattordici sepolture di epoca medioevale rinvenute nel Parco Archeologico della Valle dei Templi di Agrigento (Sicilia). L’obiettivo è stato l’acquisizione delle informazioni necessarie per la ricostruzione del profilo biologico di ciascun individuo, al fine di determinarne il sesso, la stima dell’età biologica alla morte, la stima della statura e la valutazione delle patologie e degli indicatori di stress occupazionale mediante le correnti metodologie e tecniche diagnostiche di tipo antropologico. Sebbene il cattivo stato di conservazione di alcuni individui non ne…

Summary ― The work presents the results of the bio-archaeological analyzes carried out on human skeletal remains found in fourteen burials of Medieval chronology at the Archaeological Park of Valle dei Templi in Agrigentum (Sicily). The aim of the work was the acquisition of the information necessary for the reconstruction of the biological profile of each individual throught the determination of sex the estimate of the biological age at death the estimate of height and the evaluation of pathologies and markers of occupational stress through current anthropological diagnostic methodologies and techniques. Althought the poor state of conservation of some individuals has not allowed their whole anthropological characterization the investigations have highlighted the heterogeneity relating to the age groups and have allowed us to ascertain the presence of pathological alterations in subjects of mature age sometimes of unknown etiology such as DISH (Diffuse Idiopathic Hyperostosis). The sample size is not representative of the entire population but subsequent insights will provide a better understanding of the population dynamics of Medieval Agrigentum.Settore BIO/08 - Antropologia
researchProduct

Application of Thermographic Techniques for the Detection of Failures on Photovoltaic Modules

2019

The paper focuses on thermography as a useful investigation tool for diagnosis, detection and prevention of failures of photovoltaic modules. The paper describes the faults detectable by thermographic investigations and how to conduct these investigantions. Then the results of some analyses conducted on a photovoltaic field are presented. The investigations made possible to identify faulty modules with hot spots by measuring localized superheat due to the presence of concentrated deposits on the exposed surface of the module and the superheating due to the presence of sand/dust deposits distributed on a significant portion of the module surface. The thermographic investigations can be used …

SuperheatingSettore ING-IND/33 - Sistemi Elettrici Per L'EnergiaComputer sciencefaults PV modules thermographic investigations020209 energy020208 electrical & electronic engineeringThermographyPhotovoltaic system0202 electrical engineering electronic engineering information engineeringSettore ING-IND/10 - Fisica Tecnica Industriale02 engineering and technologySettore ING-IND/32 - Convertitori Macchine E Azionamenti ElettriciAutomotive engineering
researchProduct

La tutela del lavoro nell’impresa sequestrata o confiscata tra contratto e mercato

2020

Il saggio esamina il sistema delle regole che ineriscono la gestione della forza lavoro nell’impresa sequestrata o confiscata per metterne in luci pregi e criticità. La ricerca mette in particolare in luce i limiti della tesi che fa leva sulla prevalenza della disciplina contenuta nell’art. 56 del d.lgs. n. 159/2011 sulle regole generali. Il tema è indagato attraverso materiale giurisprudenziale in parte inedito e una valutazione critica del ruolo del sindacato.

The essay is an n investigation into the system of rules relating to the management of the workforce in the seized or confiscated company to highlight its merits and critical issues.The research highlights the limits of the thesis about prevalence of the discipline contained in art. 56 of Legislative Decree 159/2011 on general rules. The issue is investigated through a partly unpublished case law material and with a critical evaluation of the role of trade un- ions.Settore IUS/07 - Diritto Del Lavoro
researchProduct

L'intonaco Li Vigni nell'architettura del XX secolo a Palermo. Nuove conoscenze e applicazioni diagnostiche per la manutenzione

2013

Il saggio presenta lo studio degli intonaci formulati per imitare le pietre e i marmi naturali che si diffondono in Sicilia all’inizio del XX secolo ed evidenzia che le prime applicazioni e la diffusione delle nuove malte, anche nel resto dell’Italia, risentono delle sperimentazioni condotte in tutta l’Europa. Il contributo riassume i risultati di una rigorosa e capillare ricognizione tra i brevetti conservati presso l’Archivio Centrale dello Stato a Roma inerenti alle malte per il confezionamento dell’intonaco a “finta pietra”, ne analizza i contenuti in modo critico e pone in risalto i contatti culturali con le sperimentazioni dei materiali in atto nell’ambito dei grandi cantieri di resta…

The paper presents the study of the plaster formulated to imitate the natural stones and marbles that are popular in Sicily in the early twentieth century and points out that the first applications and the dissemination of new mortars also in the rest of Italy feels the influence of the experiments conducted throughout Europe . The contribution summarizes the results of a rigorous and thorough reconnaissance of patents kept in the Archivio Centrale dello Stato in Rome relating to mortars for plastering an artificial stone critically analyzes the content and emphasizes cultural contacts with the experiments on large-scale restoration projects in Italy and France in the late nineteenth century. The analysis of the architectural surfaces is developed with instrumental tests: the levels of adhesion of finishing surface are characterized in particular through a campaign of thermographic investigations and diagnosis is drawn to show that the consolidation of the layers and reintegration are interventions to be introduced ​​within the restoration project and maintenance program.Settore ICAR/19 - Restauro
researchProduct

The Italian Method of la drammatica: its Legacy and Reception

2014

The volume The Italian Method of la drammatica: its Legacy and Reception includes the long and complex investigation to identify the Italian acting-code system of the drammatica used by nineteenth-century Italian actors such as Adelaide Ristori Giovanni Grasso Tommaso Salvini Eleonora Duse. In particular their acting inspired Stanislavky who reformed twentieth-century stage. The declamatory code of the drammatica was composed by symbols for notation of voice and gesture which Italian actors marked in their prompt-books. The discovery of the drammatica’s code sheds new light on nineteenth-century acting. Having deciphered the phonetic symbols of the code Anna Sica has given birth an investigation with a group of outstanding scholars in an attempt to explore the drammatica’s legacy and its reception in Europe as well as in Asia. At this stage new evidence has emerged proving that for instance the symbol used by the drammatica actors to sign the colorito vocale was known to English actors in the second half of the nineteenth century. By noting how Adelaide Ristori passed on her art to Irving’s actress Genevieve Ward and how Stanislavsky almost aflame moulded his system from Duse’s acting an unexplored variety in the reception of the drammatica’s legacy is revealed.Settore L-ART/05 - Discipline Dello Spettacolo
researchProduct

Histological and immunohistochemical findings in a fatal case of thrombotic thrombocytopenia after ChAdOx1 nCov-19 vaccination

2021

This case report describes a fatal case of a young woman with superior sagittal, transverse and sigmoid sinus thrombosis after administration of the ChAdOx1 nCov-19 vaccination. Eleven days post-vaccination she was found unconscious and transferred to the Emergency Department. Blood parameters showed low platelets, and a CT scan showed an extensive left intracranial hemorrhage and the presence of an occlusive thrombus of the superior sagittal sinus. She under-went a craniectomy, but after the intervention, she remained in a comatose state. After a few days, her clinical conditions worsened, and she died. A complete autopsy was performed which showed a thrombosis of the cerebral venous distr…

Thrombotic cerebral sinusAdultPost-mortem investigationCOVID-19Cell BiologyThrombotic thrombocytopeniaSinus ThrombosisIntracranialThrombocytopeniaPathology and Forensic MedicineSinus Thrombosis IntracranialFatal OutcomeAutopsy ChAdOx1 nCov-19 vaccination Post-mortem investigation Thrombotic cerebral sinus Thrombotic thrombocytopenia VaccineChAdOx1 nCoV-19HumansFemaleAutopsyChAdOx1 nCov-19 vaccinationVaccinePathology - Research and Practice
researchProduct

A critical evaluation of caplacizumab for the treatment of acquired thrombotic thrombocytopenic purpura

2020

Introduction: Acquired thrombotic thrombocytopenic purpura (aTTP) is a thrombotic microangiopathy caused by inhibitory autoantibodies against ADAMTS13 protein. Until recently, the combination of plasma exchange (PEX) and immunosuppression has been the standard front-line treatment in this disorder. However, aTTP-related mortality, refractoriness, and relapse are still a matter of concern. Areas covered: The better understanding of the pathophysiological mechanisms of aTTP has allowed substantial improvements in the diagnosis and treatment of this disease. Recently, the novel anti-VWF nanobody caplacizumab has been approved for acute episodes of aTTP. Caplacizumab is capable to block the adh…

Thrombotic microangiopathyExacerbationvirusesmedicine.medical_treatmentADAMTS13 ProteinDiseaseBioinformaticsAutoantigens03 medical and health sciencesPlatelet Adhesiveness0302 clinical medicineFibrinolytic AgentsProtein DomainsCrotalid Venomsvon Willebrand FactormedicineHumansImmunologic FactorsMulticenter Studies as TopicLectins C-TypeMolecular Targeted TherapyDrug ApprovalClinical Trials as TopicAcquired Thrombotic Thrombocytopenic PurpuraPlasma ExchangePurpura Thrombotic Thrombocytopenicbusiness.industryStandard treatmentfungiImmunosuppressionDrugs InvestigationalHematologyAptamers NucleotideSingle-Domain Antibodiesbiochemical phenomena metabolism and nutritionmedicine.diseaseCombined Modality TherapyRecombinant ProteinsADAMTS13AcetylcysteineTreatment Outcome030220 oncology & carcinogenesisDrug Therapy CombinationCaplacizumabbusinessImmunosuppressive Agents030215 immunologyExpert Review of Hematology
researchProduct

Early cardiovascular events in women with a history of gestational diabetes mellitus

2016

International audience; Background: The effect of gestational diabetes mellitus (GDM) on cardiovascular diseases (CVD) is not assessed within the first 10 years postpartum, regardless of subsequent diabetes. The aim of this study was to determine the risk of CVD events related to GDM within 7 years of postpartum.Methods: This nationwide population-based study of deliveries in 2007 and 2008 with a follow-up of 7 years was based on data from the French medico-administrative database. Two groups were formed: women with a history of GDM and women without GDM or previous diabetes. CVD included angina pectoris, myocardial infarction, stroke, heart bypass surgery, coronary angioplasty, carotid end…

Time FactorsDatabases Factualendocrine system diseasesEndocrinology Diabetes and MetabolismComorbidity030204 cardiovascular system & hematologyVascular dysfunctionAnginaDiabetes mellitus0302 clinical medicineRisk FactorsPregnancyOdds RatioPrevalenceGestational diabetesOriginal InvestigationCoronary diseaseeducation.field_of_study[ SDV.MHEP.CSC ] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system[ SDV.MHEP.EM ] Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolismMetaanalysis[SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolismCardiovascular disease3. Good healthGestational diabetesCardiovascular DiseasesHypertensionFemaleFranceCardiology and Cardiovascular MedicineAdultmedicine.medical_specialtyPopulationAdministrative data030209 endocrinology & metabolismRisk AssessmentYoung Adult03 medical and health sciences[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular systemInternal medicineDiabetes mellitusmedicineHumansHeart bypasscardiovascular diseasesRisk factoreducationbusiness.industryOdds ratiomedicine.diseaseComorbidityDiabetes GestationalLogistic ModelsCase-Control StudiesbusinessCardiovascular Diabetology
researchProduct

More about the developing of invisible lipstick-contaminated lipmarks on human skin: The usefulness of fluorescent dyes

2006

At the present time fingerprints are one of the simplest, and most reliable means of identification. Increasingly, crime scene investigators look for palm, foot, ear or lip prints. With regard to lip prints, the use, very common today, of protective or permanent lipsticks allow the production an invisible lipmark (or invisible lipstick-contaminated lipmark) which is possible to develop. Some results have already been published about developers useful for different kinds of surfaces (both porous and non-porous) as well as those which are more efficient in case of old or recent prints. The latest studies are about the developing on human skin, and they prove the usefulness of lysochromes (spe…

Ultraviolet Raysmedia_common.quotation_subjectHuman skinCosmeticsCosmeticsPathology and Forensic MedicineVisual artsForensic engineeringHumansMedicineCrime sceneFluorescent DyesSkinmedia_commonbusiness.industryGeneral MedicineForensic MedicineLipstickCrime investigationLipLIP PRINTSSudan blackIndicators and ReagentsPowdersbusinessLawJournal of Forensic and Legal Medicine
researchProduct