Search results for " jun"
showing 10 items of 611 documents
Expression of the ALS-causing variant hSOD1G93A leads to an impaired integrity and altered regulation of claudin-5 expression in an in vitro blood–sp…
2015
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by progressive paralysis due to the loss of primary and secondary motor neurons. Mutations in the Cu/Zn-superoxide dismutase (SOD1) gene are associated with familial ALS and to date numerous hypotheses for ALS pathology exist including impairment of the blood–spinal cord barrier. In transgenic mice carrying mutated SOD1 genes, a disrupted blood–spinal cord barrier as well as decreased levels of tight junction (TJ) proteins ZO-1, occludin, and claudin-5 were detected. Here, we examined TJ protein levels and barrier function of primary blood–spinal cord barrier endothelial cells of presymptomatic hSOD1G93…
Influence of mobile ions on the electroluminescence characteristics of methylammonium lead iodide perovskite diodes
2016
In this work, we study the effect of voltage bias on the optoelectronic behavior of methylammonium lead iodide planar diodes. Upon biasing the diodes with a positive voltage, the turn-on voltage of the electroluminescence diminishes and its intensity substantially increases. This behavior is reminiscent of that observed in light-emitting electrochemical cells (LECs), single-layer electroluminescent devices in which the charge injection is assisted by the accumulation of ions at the electrode interface. Because of this mechanism, performances are largely independent from the work function of the electrodes. The similarities observed between planar perovskite diodes and LECs suggest that mobi…
PARD3 Inactivation in Lung Squamous Cell Carcinomas Impairs STAT3 and Promotes Malignant Invasion.
2015
Abstract Correct apicobasal polarization and intercellular adhesions are essential for the appropriate development of normal epithelia. Here, we investigated the contribution of the cell polarity regulator PARD3 to the development of lung squamous cell carcinomas (LSCC). Tumor-specific PARD3 alterations were found in 8% of LSCCs examined, placing PARD3 among the most common tumor suppressor genes in this malignancy. Most PAR3-mutant proteins exhibited a relative reduction in the ability to mediate formation of tight junctions and actin-based protrusions, bind atypical protein kinase C, activate RAC1, and activate STAT3 at cell confluence. Thus, PARD3 alterations prevented the formation of c…
Response of micro- and macrovascular endothelial cells to starch-based fiber meshes for bone tissue engineering.
2006
The establishment of a functional vasculature is as yet an unrealized milestone in bone reconstruction therapy. For this study, fiber-mesh scaffolds obtained from a blend of starch and poly(caprolactone) (SPCL), that have previously been shown to be an excellent material for the proliferation and differentiation of bone marrow cells and thereby represent great potential as constructs for bone regeneration, were examined for endothelial cell (EC) compatibility. To be successfully applied in vivo, this tissue engineered construct should also be able to support the growth of ECs in order to facilitate vascularization and therefore assure the viability of the construct upon implantation. The ma…
Comparative analysis of the structure of temporomandibular joint in human and rabbit.
2016
In order to increase knowledge on the morphology and structure of the articular disc of the temporomandibular joint (TMJ) for a better understanding of the functional role of the same, it proceeded with an investigation on histological samples in the block of TMJ and periarticular tissues of adult rabits and human fatustes at different stage of development. (www.actabiomedica.it)
AUTOPHAGY AND APOPTOSIS MODULATION BY AQUEOUS EXTRACTS FROM LEAVES AND RHIZOMES OF Posidonia oceanica ON HEPG2 HEPATOCARCINOMA CELLS
2023
Josephson-junction-based axion detection through resonant activation
2022
We discuss the resonant activation phenomenon on a Josephson junction due to the coupling of the Josephson system with axions. We show how such an effect can be exploited for axion detection. A nonmonotonic behavior, with a minimum, of the mean switching time from the superconducting to the resistive state versus the ratio of the axion energy and the Josephson plasma energy is found. We demonstrate how variations in switching times make it possible to detect the presence of the axion field. An experimental protocol for observing axions through their coupling with a Josephson system is proposed.
Generation of travelling sine-Gordon breathers in noisy long Josephson junctions
2022
The generation of travelling sine-Gordon breathers is achieved through the nonlinear supratransmission effect in a magnetically driven long Josephson junction, in the presence of losses, a current bias, and a thermal noise source. We demonstrate how to exclusively induce breather modes by means of controlled magnetic pulses. A nonmonotonic behavior of the breather-only generation probability is observed as a function of the noise intensity. An experimental protocol providing evidence of the Josephson breather's existence is proposed.
Ac-locking of thermally-induced sine-Gordon breathers
2023
A complete framework for exciting and detecting thermally-induced, stabilized sine-Gordon breathers in ac-driven long Josephson junctions is developed. The formation of long-time stable breathers locked to the ac source occurs for a sufficiently high temperature. The latter emerges as a powerful control parameter, allowing for the remarkably stable localized modes to appear. Nonmonotonic behaviors of both the breather generation probability and the energy spatial correlations versus the thermal noise strength are found. The junction's resistive switching characteristics provides a clear experimental signature of the breather.
Giunzione a espansione, in particolare per il montaggio di parti mobili
2018
La presente invenzione ha come oggetto una giunzione che può essere impiegata nell'ambito del montaggio di mobili da assemblare, in particolare per l'unione di elementi piani, senza utilizzo di alcun attrezzo da lavoro, né altre tipologie di giunzioni o di collanti. The present invention relates to a joint which can be used in the assembly of furniture to be assembled, in particular for joining flat elements, without using any work tools, or other types of joints or adhesives.