Search results for " kappa"
showing 10 items of 61 documents
Comparison of the planimetry and point-counting methods for the assessment of the size of the mandible cysts on orthopantomograms
2011
Sahin, Bunyamin/0000-0001-8538-8443 WOS: 000304343300015 PubMed: 22143725 Objective: The purpose of this study is to compare the computer-assisted planimetry and point-counting methods in evaluating the sizes of the mandibular cysts with respect to their agreement and the time required to analyze. Study Design: The surface areas of 46 mandibular cyst lesions on orthopantomograms were estimated using the point-counting and computer-assisted planimetry methods. Three observers evaluated the outlined areas twice, using the point-counting (PC) and computer-assisted planimetry (CAP) methods with an interval of two weeks. In the planimetry technique, digitalized images and ImageJ software were us…
On the opioid receptor subtype inhibiting the evoked release of 3H-noradrenaline from guinea-pig atria in vitro
1986
1. Guinea-pig isolated atria were incubated and loaded with 3H-(−)-noradrenaline. The intrinsic nerves were stimulated with trains of 5 or 35 field pulses (4 Hz), and the evoked efflux of 3H-noradrenaline and of total tritium was determined in the presence of atropine, corticosterone, desipramine, and phentolamine by liquid scintillation spectrometry. 2. Ethylketocyclazocine (1.4 nmol/l, IC50), MR 2033 (9.1 nmol/l), dynorphin A (1–13) (25 nmol/l, peptidase inhibitors present), etorphine (71 nmol/l), and [d-Ala2, d-Leu5]-enkephalin (>10 μmol/l, peptidase inhibitors present) inhibited the stimulation-evoked efflux of 3H-noradrenaline in a concentration-dependent manner, but not morphine up to…
S-Detect characterization of focal solid breast lesions: a prospective analysis of inter-reader agreement for US BI-RADS descriptors
2020
Background: To assess inter-reader agreement for US BI-RADS descriptors using S-Detect: a computer-guided decision-making software assisting in US morphologic analysis. Methods: 73 solid focal breast lesions (FBLs) (mean size: 15.9 mm) in 73 consecutive women (mean age: 51 years) detected at US were randomly and independently assessed according to the BI-RADS US lexicon, without and with S-Detect, by five independent reviewers. US-guided core-biopsy and 24-month follow-up were considered as standard of reference. Kappa statistics were calculated to assess inter-operator agreement, between the baseline and after S-Detect evaluation. Agreement was graded as poor (≤ 0.20), moderate (0.21–0.40)…
Is measurement of the gingival biotype reliable? Agreement among different assessment methods.
2019
Background To determine agreement among the most commonly used methods for assessing the gingival biotype. Material and Methods An electronic survey was sent to a sample of dentists practicing in Spain. The questionnaire was based on the evaluation of 5 cases involving different gingival biotype assessment methods. Dentists were required to classify the cases as having a “thin”, “thick” or “not able to classify” biotype. Each case was assessed using a frontal intraoral photo of the anterior teeth; an enlarged photo of the buccal aspect of the tooth with a periodontal probe inserted inside the sulcus; and the real thickness measured in mm with a calibrated needle. Agreement among the classif…
Statement validity assessment: Inter-rater reliability of criteria-based content analysis in the mock-crime paradigm
2005
Methods. Three raters were trained in CBCA. Subsequently, they analysed transcripts of 102 statements referring to a simulated theft of money. Some of the statements were based on experience and some were confabulated. The raters used 4-point scales, respectively, to judge the degree to which 18 of the 19 CBCA criteria were fulfilled in each statement. Results. The analysis of rater judgment distributions revealed that, with judgments of individual raters varying only slightly across transcripts, the weighted kappa coefficient, the product-moment correlation, and the intra-class correlation were inadequate indices of reliability. The Finn-coefficient and percentage agreement, which were cal…
Synthesis of 8-aminomorphans with high KOR affinity
2021
2-Azabicyclo[3.3.1]nonanes (morphans) with a (3,4-dichlorophenyl)acetyl group at 2-position and a pyrrolidino moiety at 8-position were designed as conformationally restricted analogs of piperidine-based KOR agonists. The synthesis started with 4-oxopiperidine-2-carboxylic acid comprising 13 reaction steps. At first the ketone 10 was transformed into diester 7 bearing a propionate side chain. Dieckmann condensation of diester 7 to afford bicyclic enolester 14 and subsequent Krapcho deethoxycarbonylation represent the key steps of the synthesis. The enantiomeric pyrrolidines (1S,5R,8R)-5a and (1R,5S,8S)-5a were separated by chiral HPLC. The eutomer (1S,5R,8R)-5a showed high KOR affinity (K-i…
CREAPP K6-12: Tool to evaluate the creative potential of app oriented to the design of personal digital storytelling
2018
An instrument is presented that allows primary school teachers to evaluate the potentiality to develop creativity that have playful online app K6-12 focused on the development of digital storytelling (DST), so they can select those that can be used in the classroom for that purpose. The instrument validated consists of 48 indicators associated with the six dimensions of the creativity: flexibility, originality, fluency, problem solving, elaboration of products and co-edition and dissemination. It was designed based on the opinions of experts in creativity and Information and Communication Technologies of the didactic field, theory of education and methodology; also with the assessments and…
Preclinical evidence of new opioid modulators for the treatment of addiction.
2010
Addiction to opiates is one of the most severe forms of substance dependence, and despite a variety of pharmacological approaches to treat it, relapse is observed in a high percentage of subjects. New pharmacological compounds are necessary to improve the outcome of treatments and reduce adverse side effects. Moreover, drugs that act on the opioid system can also be of benefit in the treatment of alcohol or cocaine addiction. AREA COVERED BY THIS REVIEW: Recent preclinical studies of pharmacological agents for the treatment of opiate addiction (2008 to the present date).The reader will be informed of the latest drugs shown in animal models to modify dependence on opiates and the reinforcing…
Clasificación de usos del suelo a partir de imágenes Sentinel-2
2017
[EN] Sentinel-2 (S2), a new ESA satellite for Earth observation, accounts with 13 bands which provide high-quality radiometric images with an excellent spatial resolution (10 and 20 m) ideal for classification purposes. In this paper, two objectives have been addressed: to determine the best classification method for S2, and to quantify its improve-ment with respect to the SPOT operational mission. To do so, four classifiers (LDA, RF, Decision Trees, K-NN) have been selected and applied to two different agricultural areas located in Valencia (Spain) and Buenos Aires (Argentina). All classifiers were tested using, on the one hand, all the S2 bands and, on the other hand, only selecting those…
Assessing the performance of GIS- based machine learning models with different accuracy measures for determining susceptibility to gully erosion
2019
Assessing the performance of GIS- based machine learning models withdifferent accuracy measures for determining susceptibility togully erosionYounes Garosia, Mohsen Sheklabadia,⁎, Christian Conoscentib, Hamid Reza Pourghasemic,d, Kristof Van Ooste,faFaculty of Agriculture, Department of Soil Science, Bu Ali Sina University, Ahmadi Roshan Avenue, 6517838695 Hamedan, IranbDepartment of Earth and Sea Sciences (DISTEM), University of Palermo, Via Archirafi22, 90123 Palermo, ItalycCollege of Marine Sciences and Engineering, Nanjing Normal University, Nanjing, 210023, ChinadDepartment of Natural Resources and Environmental Engineering, College of Agriculture, Shiraz University, Shiraz, IraneA- Fo…