Search results for " learning"
showing 10 items of 5299 documents
Editing prototypes in the finite sample size case using alternative neighborhoods
1998
The recently introduced concept of Nearest Centroid Neighborhood is applied to discard outliers and prototypes 111 class overlapping regions in order to improve the performance of the Nearest Neighbor rule through an editing procedure, This approach is related to graph based editing algorithms which also define alternative neighborhoods in terms of geornetric relations, Classical editing algorithms are compared to these alternative editing schemes using several synthetic and real data problems. The empirical results show that, the proposed editing algorithm constitutes a good trade-off among performance and computational burden.
Enter the Serious E-scape Room: A Cost-Effective Serious Game Model for Deep and Meaningful E-learning
2019
Escape rooms are a phenomenon that has taken the world by storm in the last decade. Simultaneously Virtual Reality is a promising technology for innovation in education, training and e-learning. Combining these two concepts, this paper outlines a new model for designing serious games in virtual reality environments for high quality, deep and meaningful learning, the Serious E-scape Room. It describes the theoretical grounding, general guidelines and principles of the model. It also presents the case study “Room of Keys”, a serious virtual escape room for biology concepts. To test the assumptions of the model, researchers conducted a mixed research study with 148 students in a US high school…
Advancing Deep Learning for Earth Sciences: From Hybrid Modeling to Interpretability
2020
Machine learning and deep learning in particular have made a huge impact in many fields of science and engineering. In the last decade, advanced deep learning methods have been developed and applied to remote sensing and geoscientific data problems extensively. Applications on classification and parameter retrieval are making a difference: methods are very accurate, can handle large amounts of data, and can deal with spatial and temporal data structures efficiently. Nevertheless, several important challenges need still to be addressed. First, current standard deep architectures cannot deal with long-range dependencies so distant driving processes (in space or time) are not captured, and the…
A Machine Learning-Based Prediction Platform for P-Glycoprotein Modulators and Its Validation by Molecular Docking
2019
P-glycoprotein (P-gp) is an important determinant of multidrug resistance (MDR) because its overexpression is associated with increased efflux of various established chemotherapy drugs in many clinically resistant and refractory tumors. This leads to insufficient therapeutic targeting of tumor populations, representing a major drawback of cancer chemotherapy. Therefore, P-gp is a target for pharmacological inhibitors to overcome MDR. In the present study, we utilized machine learning strategies to establish a model for P-gp modulators to predict whether a given compound would behave as substrate or inhibitor of P-gp. Random forest feature selection algorithm-based leave-one-out random sampl…
Feature Extraction and Selection for Pain Recognition Using Peripheral Physiological Signals.
2019
In pattern recognition, the selection of appropriate features is paramount to both the performance and the robustness of the system. Over-reliance on machine learning-based feature selection methods can, therefore, be problematic; especially when conducted using small snapshots of data. The results of these methods, if adopted without proper interpretation, can lead to sub-optimal system design or worse, the abandonment of otherwise viable and important features. In this work, a deep exploration of pain-based emotion classification was conducted to better understand differences in the results of the related literature. In total, 155 different time domain and frequency domain features were e…
ADME Prediction with KNIME: Development and Validation of a Publicly Available Workflow for the Prediction of Human Oral Bioavailability.
2020
In silico prediction of human oral bioavailability is a relevant tool for the selection of potential drug candidates and for the rejection of those molecules with less probability of success during the early stages of drug discovery and development. However, the high variability and complexity of oral bioavailability and the limited experimental data in the public domain have mainly restricted the development of reliable in silico models to predict this property from the chemical structure. In this study we present a KNIME automated workflow to predict human oral bioavailability of new drug and drug-like molecules based on five machine learning approaches combined into an ensemble model. Th…
Contextualized project-based learning for training chemical engineers in graphic expression
2021
Abstract This paper describes the planning of a computer-aided design (CAD) laboratory for training chemical engineers in graphic expression. The CAD laboratory was organised into four projects following a project-based learning method. Flipped classroom and contextualised learning were used to motivate the students and promote meaningful learning. The laboratory mainly focused on engaging the students by replicating 2D and 3D plans of common industrial engineering equipment and piping and instrumentation diagrams of industrial facilities. Two surveys carried out before and after the course showed that the student’s perception of their graphic expression skills significantly increased. Gend…
Advanced computation in cardiovascular physiology: New challenges and opportunities
2021
Recent developments in computational physiology have successfully exploited advanced signal processing and artificial intelligence tools for predicting or uncovering characteristic features of physiological and pathological states in humans. While these advanced tools have demonstrated excellent diagnostic capabilities, the high complexity of these computational 'black boxes’ may severely limit scientific inference, especially in terms of biological insight about both physiology and pathological aberrations. This theme issue highlights current challenges and opportunities of advanced computational tools for processing dynamical data reflecting autonomic nervous system dynamics, with a speci…
Multi-agent Reinforcement Learning for Simulating Pedestrian Navigation
2012
In this paper we introduce a Multi-agent system that uses Reinforcement Learning (RL) techniques to learn local navigational behaviors to simulate virtual pedestrian groups. The aim of the paper is to study empirically the validity of RL to learn agent-based navigation controllers and their transfer capabilities when they are used in simulation environments with a higher number of agents than in the learned scenario. Two RL algorithms which use Vector Quantization (VQ) as the generalization method for the space state are presented. Both strategies are focused on obtaining a good vector quantizier that generalizes adequately the state space of the agents. We empirically state the convergence…
Deep Learning-Based Methods for Prostate Segmentation in Magnetic Resonance Imaging
2021
Magnetic Resonance Imaging-based prostate segmentation is an essential task for adaptive radiotherapy and for radiomics studies whose purpose is to identify associations between imaging features and patient outcomes. Because manual delineation is a time-consuming task, we present three deep-learning (DL) approaches, namely UNet, efficient neural network (ENet), and efficient residual factorized convNet (ERFNet), whose aim is to tackle the fully-automated, real-time, and 3D delineation process of the prostate gland on T2-weighted MRI. While UNet is used in many biomedical image delineation applications, ENet and ERFNet are mainly applied in self-driving cars to compensate for limited hardwar…