Search results for " lip"
showing 10 items of 1180 documents
Multicompartmental Lipopolyplex as Vehicle for Antigens and Genes Delivery in Vaccine Formulations
2021
Vector design and its characterization is an area of great interest in current vaccine research. In this article, we have formulated and characterized a multicompartmental lipopolyplex, which associates multiple liposomes and polyplexes in the same complex. These particles allow the simultaneous delivery of lipid or water-soluble antigens associated with genes to the same cell, in much higher amounts than conventional lipopolyplexes. The vector characterization and optimization were carried out using liposomes with entrapped carboxyfluorescein and adapted electrophoretic assays. Two types of lipopolyplexes (containing hydrophilic or lipophilic antigens) were employed to evaluate their inter…
Binding of RNA Aptamers to Membrane Lipid Rafts: Implications for Exosomal miRNAs Transfer from Cancer to Immune Cells
2020
Intraluminal vesicles (ILVs) are released into the extracellular space as exosomes after the fusion of multivesicular bodies (MVBs) with the plasma membrane. miRNAs are delivered to the raft-like region of MVB by RNA-binding proteins (RBPs). RNA loading into exosomes can be either through direct interaction between RNA and the raft-like region of the MVB membrane, or through interaction between an RBP&ndash
Existence and classification of critical points for nondifferentiable functions
2004
A general min-max principle established by Ghoussoub is extended to the case of functionals which are the sum of a locally Lipschitz continuous term and of a convex, proper, lower semicontinuous function. Some topological properties of the min-max-generated critical points in such a framework are then pointed out.
The significance of low-density lipoproteins size in vascular diseases
2006
Low density lipoproteins (LDL) comprise in humans two different main fractions: large, buoyant and small, dense particles. Small, dense LDL particles correlate negatively with plasma HDL levels and positively with plasma triglyceride concentrations and are associated with the metabolic syndrome and increased risk for cardiovascular disease. LDL size seems to be an important predictor of cardiovascular events and progression of coronary heart disease (CHD). In addition, several studies have suggested that therapeutic modulation of specific LDL subclasses may be of great benefit in reducing the atherosclerotic risk. Therefore, LDL size measurement may be of potential value in the clinical ass…
Alfavīrusu genomiskās RNS piegāde audzēju šūnu kultūrās, izmantojot lipofilos 1,4-dihidropiridīna atvasinājumus
2015
Alfavīrusu genoms ir aptuveni 11,5 kb gara vienpavediena, pozitīvas ķēdes RNS, kuru ir potenciāls izmantot antigēnu kodējošu, pašamplificējošu RNS vakcīnu izstrādē. Lai veidotu stabilu piegādes sistēmu bieži tiek izmantoti lipofili aģenti ar katjonu īpašībām, piemēram, 1,4-dihidropiridīna atvasinājumi. Šādi lipopleksi jau ir uzrādījuši teicamus rezultātus nukleīnskābju vakcīnu preparātu izstradē. Salīdzinot ar virālajām piegādes sistēmām, tiek apietas problēmas, kas saistītas ar anti-vektora imunitāti, citotoksicitāti un biodrošību. Šajā darbā tika veikta alfavīrusu genomiskās RNS rekSFV1/Ds-Red un 1,4-dihidropiridīnu atvasinājumu lipopleksu veidošanas optimizācija, lai panāktu maksimāli ef…
Solvability of a first order system in three-dimensional non-smooth domains
1985
summary:A system of first order partial differential equations is studied which is defined by the divergence and rotation operators in a bounded nonsmooth domain $\Omega\subset \bold R^3$. On the boundary $\delta\Omega$, the vanishing normal component is prescribed. A variational formulation is given and its solvability is investigated.
Feromagnētiskas nanodaļiņas un to pielietojums mīkstu materiālu (dihidropiridīna tipa lipīdu organiski savienojumi, polimēri) funkcionalizācijai
2014
Elektroniskā versija nesatur pielikumus
High Lipid Content of Prey Fish and n−3 PUFA Peroxidation Impair the Thiamine Status of Feeding-Migrating Atlantic Salmon (Salmo salar) and Is Reflec…
2022
Signs of impaired thiamine (vitamin B1) status in feeding-migrating Atlantic salmon (Salmo salar) were studied in three Baltic Sea areas, which differ in the proportion and nutritional composition of prey fish sprat (Sprattus sprattus) and herring (Clupea harengus). The concentration of n−3 polyunsaturated fatty acids (n−3 PUFAs) increased in salmon with dietary lipids and n−3 PUFAs, and the hepatic peroxidation product malondialdehyde (MDA) concentration increased exponentially with increasing n−3 PUFA and docosahexaenoic acid (DHA, 22:6n−3) concentration, whereas hepatic total thiamine concentration, a sensitive indicator of thiamine status, decreased with th…
Two examples related to conical energies
2022
In a recent article we introduced and studied conical energies. We used them to prove three results: a characterization of rectifiable measures, a characterization of sets with big pieces of Lipschitz graphs, and a sufficient condition for boundedness of nice singular integral operators. In this note we give two examples related to sharpness of these results. One of them is due to Joyce and M\"{o}rters, the other is new and could be of independent interest as an example of a relatively ugly set containing big pieces of Lipschitz graphs.
The differential effects of thiazolidindiones on atherogenic dyslipidemia in type 2 diabetes: what is the clinical significance?
2008
Diabetic dyslipidemia is typically characterized by an increase in plasma triglycerides, a decrease in high-density lipoprotein cholesterol and a concomitant increase in atherogenic small dense low-density lipoproteins. Thiazolidindiones are able to lower the levels of fasting glucose and glycated hemoglobin significantly by improving insulin sensitivity, as well as improving some aspects of diabetic dyslipidemia: total cholesterol, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol tend to increase while triglycerides are generally decreased.This paper reviewed the effects of pioglitazone and rosiglitazone on atherogenic diabetic dyslipidemia, in particular on sma…