Search results for " locali"
showing 10 items of 539 documents
Increased AICD generation does not result in increased nuclear translocation or activation of target gene transcription.
2008
A sequence of amyloid precursor protein (APP) cleavages culminates in the sequential release of the APP intracellular domain (AICD) and the amyloid beta peptide (Abeta) and/or p3 fragment. One of the environmental factors favouring the accumulation of AICD appears to be a rise in intracellular pH. Here we further identified the metabolism and subcellular localization of artificially expressed constructs under such conditions. We also co-examined the mechanistic lead up to the AICD accumulation and explored possible significances for its increased expression. We found that most of the AICD generated under pH neutralized conditions is likely cleaved from C83. While the AICD surplus was unable…
Il diritto di accesso nell'ordinamento degli enti locali: un problema ancora aperto
2002
L'articolo esamina il rapporto tra la l.n.142 del 1990 e la l.n. 241 del 1990 in materia di accesso agli atti amministrativi
Difusión y localización industrial en España durante el primer tercio del siglo XX.
1999
El propósito del trabajo es estudiar la difusión de los cambios hacia una estructura industrial manufacturera diversificada en las diferentes regiones españolas durante el primer tercio del siglo XX y la evaluación de los factores que explican el crecimiento de la industria manufacturera de estas regiones. Los factores considerados son las economías de localización (externalidades marshallianas) y las economías de urbanización (externalidades de Jacobs). Como no existe un censo industrial en España, se ha estimado una reconstrucción de los impuestos directos industriales en 1913 y 1929 para 50 provincias y 20 manufacturas. En este período de creación de una importante base manufacturera par…
Diversity and taxonomy of the genus Unio Philipsson in Italy, with the designation of a neotype for Unio elongatulus C. Pfeiffer (Mollusca, Bivalvia,…
2019
Novel Unio spp. populations from Slovenia, the Italian peninsula, Sardinia and Sicily were genetically analysed in order to define the distribution and diversity of the genus Unio in Italy and neighbouring areas. The presence of two primarily allopatric autochtonous species, Unio elongatulus Pfeiffer, and Unio mancus Lamarck, is confirmed for the Italian peninsula, Corsica, Sardinia, and Sicily. Autochthonous populations of Unio elongatulus are present in the peri-Adriatic drainages of the Italian and Balkan peninsulas, south as far as the Ofanto River (Apulia, Italy) and Lake Skadar (Albania), while its presence in the Tyrrhenian rivers of Tuscany is likely due to anthropogenic introductio…
Effetti spaziali o settoriali? La crescita della dimensione media d'impresa in Italia
2015
Utilizzando una recente versione della shift-share con struttura spaziale, in questo contributo scomponiamo il cambiamento della dimensione media delle imprese nelle province italiane rispetto a componenti di natura sia spaziale (di regione e di vicinato) che settoriale. L’analisi, condotta con riferimento al periodo 2004-2009, mette in risalto differenze di rilievo rispetto la classe dimensionale considerata. In particolare, si registra una netta demarcazione Nord-Sud nella distribuzione provinciale degli effetti spaziali e settoriali se consideriamo le micro imprese (1-10 addetti), mentre la geografia appare molto piu complessa per le piccole imprese (11-50 addetti).
Signal sequences modulate the immunogenic performance of human hepatitis C virus E2 gene
2005
Abstract Envelope protein E2 of human hepatitis C virus (HCV) is an attractive component of a prototype HCV vaccine. Delivered by DNA immunogens, E2 evokes specific immune response of Th1-type, failing to induce either considerable antibody production, or T-helper cell proliferation. We aimed at modulating the immunogenic performance of E2 gene by changing the mode of protein expression in eukaryotic cells. Plasmids were constructed encoding full-length E2 and nonstructural protein 1 (p7) fused to either 13 or 38 C-terminal amino acids (aa) of HCV E1 that contain second hydrophobic segment of E1 stop-transfer signal, or a complete E1 stop-transfer signal with duplicated second hydrophobic s…
Expression and cellular localization of the Nef protein from human immunodeficiency virus-1 in stably transfected B-cells.
1992
Nef protein, encoded by the regulatory nef gene of human immunodeficiency virus type 1 (HIV-1), was expressed in the B-cell line Raji. The cells were stably transfected with plasmids containing the nef transcriptional cassette. They expressed Nef with an Mr of 27,000; the yield could be augmented by incubation with the tumor promoter 12-O-tetradecanoylphorbol-13-acetate. The intracellular localization of Nef was analyzed applying immunofluorescence microscopy using a confocal laser scanning microscope. The antigen was stained with a monoclonal antibody directed against the N-terminal part of Nef. The experiments revealed that in non-dividing cells Nef is present both in the cytoplasm and th…
Coverage analysis of RFID indoor localization system for refrigerated warehouses based on 2D-ray tracing
2012
New insights in chemical reactivity from quantum chemical topology.
2021
International audience; Based on the quantum chemical topology of the modified electron localization function ELFx, an efficient and robust mechanistic methodology designed to identify the favorable reaction pathway between two reactants is proposed. We first recall and reshape how the supermolecular interaction energy can be evaluated from only three distinct terms, namely the intermolecular coulomb energy, the intermolecular exchange‐correlation energy and the intramolecular energies of reactants. Thereafter, we show that the reactivity between the reactants is driven by the first‐order variation in the coulomb intermolecular energy defined in terms of the response to changes in the numbe…
A high-temperature x-ray absorption spectroscopy study of
1996
We present for the first time a high-temperature x-ray absorption spectroscopy study of at the edge. The analysis both of the XANES and of the EXAFS regions shows that, in , a progressive localization of the 5d states following the temperature rise is accompanied at T > 350 K by a distortion of the octahedra, which increases up to the decomposition temperature . The distortion leads to the lowering of the rhenium site symmetry from and is due to the electron - phonon coupling of the 5d electrons with the and phonons and to the Jahn - Teller effect caused by the rhenium electron which becomes localized at high temperature.