Search results for " malattie."

showing 10 items of 1941 documents

Vitamin D and Osteoporosis in HIV/HCV Coinfected Patients: A Literature Review

2015

Vitamin D deficiency further increases the risk of osteoporosis in HIV-positive patients coinfected with hepatitis C virus (HCV); however, it is still unclear whether HCV-related increased fracture risk is a function of the severity of liver disease. The aim of this review was to identify studies on associative vitamin D deficiency patterns in high-risk populations such as HIV/HCV coinfected patients. We did this by searching MEDLINE and EMBASE databases, from inception to August 2014, and included bibliographies. The final 12 articles selected are homogeneous in terms of age but heterogeneous in terms of sample size, participant recruitment, and data source. Most of the HIV/HCV coinfected …

VitaminPathologymedicine.medical_specialtySettore MED/17 - Malattie InfettiveEndocrinology Diabetes and MetabolismHepatitis C virusOsteoporosisMEDLINEReview ArticleHIV/HCV coinfected patientS VITAMIN Dmedicine.disease_causelcsh:Diseases of the endocrine glands. Clinical endocrinologyvitamin D deficiencyLiver diseasechemistry.chemical_compoundEndocrinologyInternal medicinemedicineVitamin D and neurologylcsh:RC648-665Vitamin d supplementationEndocrine and Autonomic Systemsbusiness.industryvirus diseasesmedicine.diseasechemistrybusiness
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Hereditary combined deficiency of the vitamin K-dependent clotting factors

2010

Abstract Hereditary combined vitamin K-dependent clotting factors deficiency (VKCFD) is a rare congenital bleeding disorder resulting from variably decreased levels of coagulation factors II, VII, IX and X as well as natural anticoagulants protein C, protein S and protein Z. The spectrum of bleeding symptoms ranges from mild to severe with onset in the neonatal period in severe cases. The bleeding symptoms are often life-threatening, occur both spontaneously and in a surgical setting, and usually involve the skin and mucosae. A range of non-haemostatic symptoms are often present, including developmental and skeletal anomalies. VKCFD is an autosomal recessive disorder caused by mutations in …

Vitaminmedicine.medical_specialtyVitamin KCoagulation Factor Deficiencylcsh:MedicineReviewGastroenterologyProtein SProtein SSettore MED/15 - Malattie Del Sanguechemistry.chemical_compoundBlood Coagulation Disorders InheritedInternal medicineVitamin K deficiencymedicineHumansGenetics(clinical)Pharmacology (medical)VITAMIN K DEPENDENT CLOTTING FACTORS RARE INHERITED BLEEDING DISORDERSCongenital Bleeding DisorderGenetics (clinical)Medicine(all)Clotting factorbiologybusiness.industrylcsh:RVitamin K2WarfarinInfant NewbornGeneral MedicineBlood Proteinsmedicine.diseaseBlood Coagulation FactorsRecombinant ProteinschemistryCarbon-Carbon LigasesImmunologybiology.proteinVitamin K Deficiencybusinessmedicine.drugProtein C
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Su un caso di sindrome di Wolfram

2011

To aim of this paper was to offer a further contribution to the knowledge af the Wolfram Syndrome within the Italian population about hypotheses of its genetic trasmission and diagnostic problems.The study comprised the genetic investigation and the clinical ophthalmological examination of all the family members. Genetic investigation of family members showed the presence of a genetic disorder,consisting in a mutation of the gene wfs1, located on the short arm of chromosome 4, and which codifies for the protein Wolfranin. The gene wfs1 presents high penetrance and expression,since the mutation is recessive, it can only be clinicallly detected when it is present in the homozygous form. It sh…

Wolfram syndromeSettore MED/30 - Malattie Apparato Visivooptic atrophyGenetic diseases imborn
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How was the Turin Shroud Man crucified?

2014

As the literature is not exhaustive with reference to the way the Turin Shroud (TS) Man was crucified, and it is not easy to draw significant information from only a "photograph" of a man on a linen sheet, this study tries to add some detail on this issue based on both image processing of high resolution photos of the TS and on experimental tests on arms and legs of human cadavers. With regard to the TS Man hands, a first hypothesis states that the left hand of the TS Man was nailed twice at two different anatomical sites: the midcarpal joint medially to the pisiform between the lunate/pyramidal and capitate/uncinate bones (Destot's space) and the radiocarpal joint between the radio, lunate…

Wrist JointFamous PersonsMyocardial InfarctionPoison controlSettore MED/33 - Malattie Apparato LocomotoreShock TraumaticOrthopedics and Sports MedicineUlnar nerveForensic PathologyHistory AncientGeneral Environmental Scienceintegumentary systemMedicine (all)ContusionBiomechanical Phenomenamedicine.anatomical_structureMidcarpal jointNail (anatomy)Emergency MedicineTurin Shroud ManHomicideHumanmedicine.medical_specialtyCausalgiaContusionsTortureCause of deathViolenceChristianityAsphyxiaImmobilizationmedicineCadaverHumansCrucifixion techniquebusiness.industryFootWounds and InjurieFamous PersonMetacarpophalangeal jointHandSurgerybody regionsLunateTarsal BoneWounds and InjuriesGeneral Earth and Planetary SciencesForensic AnthropologyAnkleNailingbusiness
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[Takotsubo cardiomyopathy: a consensus document].

2008

Takotsubo cardiomyopathy is a syndrome characterized by acute regional systolic dysfunction of the left ventricle, frequently related to psycho-physical acute stress, and usually reversible. This rare syndrome involves more often the female sex with the highest frequency of occurrence between the seventh and eighth decade of life. Etiology has not been clarified yet and several hypotheses have been postulated: multiple epicardial coronary artery damage, abnormal coronary microcirculation, catecholamine-mediated cardiac toxicity, and neurogenic stunning. Clinical presentation is not easy to distinguish from an acute coronary syndrome: chest pain at rest or dyspnea, new-onset electrocardiogra…

acute stressTakotsubo cardiomyopathy; consensus documentRegional cardiomyopathy; acute stressRegional cardiomyopathyTakotsubo cardiomyopathycardiomyopathy stress autonomic systemSettore MED/11 - Malattie Dell'Apparato Cardiovascolareconsensus document
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Durability of Dolutegravir-Based Regimens: A 5-Year Prospective Observational Study

2021

This study evaluates the frequency and causes of dolutegravir (DTG) discontinuation along 5 years of follow-up, in both antiretroviral treatment (ART)-naive and experienced people living with HIV (PLWH). This is a prospective multi-center cohort study enrolling PLWH on DTG from July 2014 until November 2020. DTG-durability was investigated using the Kaplan-Meier survival curve. The Cox proportional-hazards model was used for estimating the hazard ratio (HR) of DTG discontinuation for any cause, and for adverse events (AEs). Nine hundred sixty-three PLWH were included, 25.3% were women and 28.0% were ART-naive. Discontinuations for any causes were 10.1 [95% confidence interval (95% CI) 8.9-1…

adverse events; dolutegravir; durability; HIV; safety; toxicity; virolgical failure; Cohort Studies; Female; Heterocyclic Compounds 3-Ring; Humans; Middle Aged; Oxazines; Piperazines; Prospective Studies; Pyridones; Anti-HIV Agents; HIV InfectionssafetyPediatricsmedicine.medical_specialtySettore MED/17 - Malattie InfettivePyridonesAnti-HIV AgentsOxazineHuman immunodeficiency virus (HIV)adverse eventHIV Infectionsvirolgical failurePyridonemedicine.disease_cause3-RingHIV Infections.PiperazinesCohort Studieschemistry.chemical_compoundHeterocyclic CompoundsHIV; adverse events; dolutegravir; durability; safety; toxicity; virolgical failureOxazinesAntiretroviral treatmentMedicineHumansProspective StudiesAdverse effectPiperazinebusiness.industryPublic Health Environmental and Occupational HealthHIVtoxicityAnti-HIV AgentMiddle Agedadverse eventsDiscontinuationdolutegravirvirolgical failure.Prospective StudieInfectious DiseaseschemistryDolutegravirdurabilityObservational studyFemaleCohort StudiebusinessHeterocyclic Compounds 3-RingHuman
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Bone marrow-derived progenitors are greatly reduced in patients with severe COPD and low-BMI.

2009

Chronic obstructive pulmonary disease (COPD) patients have reduced circulating hemopoietic progenitors. We hypothesized that severity of COPD parallels the decrease in progenitors and that the reduction in body mass index (BMI) could be associated with more severe bone marrow dysfunction. We studied 39 patients with moderate to very severe COPD (18 with low-BMI and 21 with normal-BMI) and 12 controls. Disease severity was associated to a greater reduction in circulating progenitors. Proangiogenetic and inflammatory markers correlated with disease severity parameters. Compared to normal-BMI patients, low-BMI patients showed: greater reduction in circulating progenitors; higher VEGF-A, VEGF-C…

aged; analysis of variance; antigens; blood; blood cell count; body mass index; bone marrow transplantation; case-control studies; cd; chronic obstructive; chronic obstructive pulmonary disease; colony-forming units assay; creatine kinase; cytokines; endothelial cells; enzyme-linked immunosorbent assay; fat-free mass; female; humans; intercellular signaling peptides and proteins; lactate dehydrogenases; low-bmi copd; male; metabolism; methods; middle aged; normal-bmi copd; physiology; physiopathology/surgery; pulmonary disease; severity of illness index; statistics as topicMalePathologyPhysiologyStatistics as TopicCD34GastroenterologySeverity of Illness IndexBody Mass IndexPulmonary Disease Chronic Obstructiveantigenslow-bmi copdnormal-bmi copdCreatine Kinasepulmonary diseaseBone Marrow TransplantationCOPDchronic obstructiveGeneral NeuroscienceRespiratory diseaseMiddle Agedcdfat-free massHaematopoiesismedicine.anatomical_structurephysiopathology/surgeryCytokinesIntercellular Signaling Peptides and ProteinsFemalePulmonary and Respiratory Medicinemedicine.medical_specialtyEnzyme-Linked Immunosorbent Assaymacromolecular substancesSettore MED/10 - Malattie Dell'Apparato Respiratoriochronic obstructive pulmonary diseasemethodsColony-Forming Units AssayChronic obstructive pulmonary disease low-BMI COPD normal-BMI COPD fat-free massbloodAntigens CDInternal medicineSeverity of illnessmedicineHumansProgenitor cellLactate DehydrogenasesAgedAnalysis of Variancebusiness.industryCase-control studyEndothelial Cellsmedicine.diseaseBlood Cell CountCase-Control StudiesBone marrowbusinessmetabolismRespiratory physiologyneurobiology
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Exercise-induced changes in airway cells

2007

airway inflammation; bronchial epithelial damage; remodeling induced sputum endurance trainingbronchial epithelial damageremodeling induced sputum endurance trainingairway inflammationSettore MED/10 - Malattie Dell'Apparato RespiratorioSettore BIO/09 - Fisiologia
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Aldosterone e sindromi coronariche acute: ruolo nel follow-up a breve e medio termine

2014

aldosterone sindrome coronarica acuta outcomeSettore MED/11 - Malattie Dell'Apparato Cardiovascolare
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uso degli alfa-bloccanti nell'ipertrofia prostatica benigna: il problema della "floppy iris syndrome". Risultati di uno studio caso-controllo per la …

2009

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alfa-bloccanti ipertrofia prostatica benignaDIAMETRO PUPILLAREIPERTROFIA PROSTATICAALFABLOCCANTISettore MED/30 - Malattie Apparato Visivofloppy iris syndrome
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