Search results for " map"

MTOR inhibitor-based combination therapies for pancreatic cancer

2018

Background: Although the mechanistic target of rapamycin (MTOR) kinase, included in the mTORC1 and mTORC2 signalling hubs, has been demonstrated to be active in a significant fraction of patients with pancreatic ductal adenocarcinoma (PDAC), the value of the kinase as a therapeutic target needs further clarification. Methods: We used Mtor floxed mice to analyse the function of the kinase in context of the pancreas at the genetic level. Using a dual-recombinase system, which is based on the flippase-FRT (Flp-FRT) and Cre-loxP recombination technologies, we generated a novel cellular model, allowing the genetic analysis of MTOR functions in tumour maintenance. Cross-species validation and pha…

Tīmekļa lietotne ēstuvju meklēšanai

2021

“Finder App” ir ar Laravel ietvaru veidota tīmekļa lietotne, kurā lietotājs izmantojot karti var atrast konkrētai atrašanās vietai tuvākās ēstuves. Reģistrētie lietotāji var arī pievienot sev iecienītākās ēstuves sarakstā un atsevišķi tās apskatīt. Lietotnē izmanto Google Maps un Google Places API, lai iegūtu kartes un ēdnīcu datus, kuru pēc tam parāda lietotājam kartē.

The new “Vegetation map of Sicily (Italy)”: a synthetic overview of the distribution of European habitats on the territory.

2016

The new "Vegetation map of Sicily (Italy)", recently published (Gianguzzi, Papini & Cusimano, 2015), shows also a synthetic overview of the distribution of European habitats in the territory; the study area has been extended to small islands circum-Sicilian (archipelago of the Aeolian; Aegadian, Pelagie Ustica and Pantelleria islands), for a total area of 25,703 km2. Our work allowed to resume the knowledge status of the phytosociological studies on vegetation carried out and to identify the actual plant landscape of the region; the map was compiled in a Geographical Information Systems (GIS) environment, in order to produce a cartographic representation in 1:10,000 scale (reduced to a 1:25…

Identifying the Sales Patterns of Online Stores with Self-Organising Maps on Time Series Data

2018

Electronic commerce, especially in the business-to-consumer (B2C) context, has for years been a popular research topic in information systems (IS). However, the prior research on the topic has traditionally been dominated by the consumer focus instead of the business focus of online stores. For example, whereas various segmentations exist for online consumers based on their purchase behaviour, no such segmentations have been developed for online stores based on their sales patterns. In this study, our objective is to address this gap in prior research by identifying the most typical sales patterns of online stores operating in the B2C context. By using self-organising maps (SOM) to analyse …

The extent of empirical evidence that could inform evidence-based design of programming languages : a systematic mapping study

2014

Video projection mapping e arti performative. Una nuova macchina scenotecnica della visione per generare nuovi spazi aumentati

L’oggetto principale della dissertazione è il video projection mapping, un’applicazione di realtà aumentata che utilizza le tecniche di videoproiezione digitale non su tradizionali schermi di proiezione ma sulla realtà stessa, sugli oggetti fisici, ai quali si adatta e si lega in maniera inestricabile, ibridando il livello fisico-reale e il livello digitale. Al contrario di come spesso è stato considerato, il video projection mapping non è solo un gadget tecnologico dei nostri tempi; quando si ibrida con altri media, come le arti performative, diviene linguaggio metaforico, oltrepassando il suo livello tecnologico per produrre significati, per mediare idee. Considerando il suo uso nello spe…

An unexpected representation of burgundian vineyards in the 16th century: the map of “Les Environs de l’estang de Longpendu”

2022

The Environs de l’étang de Longpendu map by Jean Vandamme shows a part of the Burgundy territory, located in the center of Charolais, probably at the end of the sixteenth century. It is representative of a complex corpus and shows, in various ways, a part of the Burgundy vineyards in the North, and Charolais forests and plains in the South. The vineyards shown are partly those occupied by today’s Côte de Beaune, Côte chalonnaise, Mâconnais and Couchois. This is one of the oldest representations of the vineyard in Burgundy, and a precious tool for documenting the dynamics of vineyard expansion from the 16th to the 21st century.

Reversed Pseudoneglect in a Virtual Reality Environment

Soft X-ray Tomography Reveals HSV-1-Induced Remodeling of Human B Cells.

2022

Upon infection, viruses hijack the cell machinery and remodel host cell structures to utilize them for viral proliferation. Since viruses are about a thousand times smaller than their host cells, imaging virus-host interactions at high spatial resolution is like looking for a needle in a haystack. Scouting gross cellular changes with fluorescent microscopy is only possible for well-established viruses, where fluorescent tagging is developed. Soft X-ray tomography (SXT) offers 3D imaging of entire cells without the need for chemical fixation or labeling. Here, we use full-rotation SXT to visualize entire human B cells infected by the herpes simplex virus 1 (HSV-1). We have mapped the temporo…

Functional properties of a monoclonal antibody inhibiting the hepatitis C virus RNA-dependent RNA polymerase.

2001

The hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp), represented by nonstructural protein 5B (NS5B), has recently emerged as a promising target for antiviral intervention. Here, we describe the isolation, functional characterization, and molecular cloning of a monoclonal antibody (mAb) inhibiting the HCV RdRp. This mAb, designated 5B-12B7, binds with high affinity to a conformational epitope in the palm subdomain of the HCV RdRp and recognizes native NS5B expressed in the context of the entire HCV polyprotein or subgenomic replicons. Complete inhibition of RdRp activity in vitro was observed at equimolar concentrations of NS5B and mAb 5B-12B7, whereas RdRp activities of classica…