Search results for " mechanisms"
showing 10 items of 476 documents
pH Feedback Lifecycles Programmed by Enzymatic Logic Gates Using Common Foods as Fuels
2021
Abstract Artificial temporal signaling systems, which mimic living out‐of‐equilibrium conditions, have made large progress. However, systems programmed by enzymatic reaction networks in multicomponent and unknown environments, and using biocompatible components remain a challenge. Herein, we demonstrate an approach to program temporal pH signals by enzymatic logic gates. They are realized by an enzymatic disaccharide‐to‐monosaccharide‐to‐sugar acid reaction cascade catalyzed by two metabolic chains: invertase‐glucose oxidase and β‐galactosidase‐glucose oxidase, respectively. Lifetimes of the transient pH signal can be programmed from less than 15 min to more than 1 day. We study enzymatic k…
Different approaches to marriage downgrading : from an anti-elusive measure to an antidiscriminatory claim
2021
The essay focuses on the different mechanisms of marriage downgrading. Given the principle of ?cross-border continuity? of statuses, limits to this continuity are sometimes admitted and they are placed through downgrading mechanisms. That can occour in the case of same-sex marriages transcription in a Member State which does not allow such marriages, but which does allow samesex registered partnerships. Downgrading mechanism has an anti-elusive function, but it is not without problems in terms of discrimination on the grounds of sexual orientation. A different approach is taken in the case of an opposite-sex couple requesting the downgrading of their marriage, celebrated before the Member S…
Protection of the surviving spouse in French law
2021
While French inheritance law has recently sought to give everyone more freedom to anticipate the transmission of their estate, it still guarantees to the children a reserved portion in his estate. This guarantees the deceased?s children a minimum share in his/her estate. However, the mechanisms protecting this reserve are subject to legal adjustments when spouses wish to organize the protection of the couple?s survivor, either by submitting to a conventional matrimonial regime or by giving themselves gifts that improve the legal succession of the spouse. This ensures a balance between the protection of the spouse and that of the compulsory heirs. Not seeming to be satisfied, several famous …
Los programas de cumplimiento penal : Aspectos generales
2021
In Spain, as in many other countries, corporate criminal liability has been a reality for years, as well as criminal compliance programs that allow them to be mitigated or exonerated from liability. In this article we will present some of the main keys to consider for the implementation of these mechanisms. This is a series of general considerations that can serve as a guide to understand the complex system of crime prevention provided by the organization and management models in the corporate environment.
Safety Evaluation of α-Lipoic Acid Supplementation: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Clinical Studies
2020
Alpha-lipoic acid (ALA) is a natural short-chain fatty acid that has attracted great attention in recent years as an antioxidant molecule. However, some concerns have been recently raised regarding its safety profile. To address the issue, we aimed to assess ALA safety profile through a systematic review of the literature and a meta-analysis of the available randomized placebo-controlled clinical studies. The literature search included EMBASE, PubMed Medline, SCOPUS, Google Scholar, and ISI Web of Science by Clarivate databases up to 15th August 2020. Data were pooled from 71 clinical studies, comprising 155 treatment arms, which included 4749 subjects with 2558 subjects treated with ALA an…
Pain Neuroscience Education and Physical Therapeutic Exercise for Patients with Chronic Spinal Pain in Spanish Physiotherapy Primary Care: A Pragmati…
2020
Producción Científica
Pharmacological activation of CB2 receptors counteracts the deleterious effect of ethanol on cell proliferation in the main neurogenic zones of the a…
2015
Chronic alcohol exposure reduces endocannabinoid activity and disrupts adult neurogenesis in rodents, which results in structural and functional alterations. Cannabinoid receptor agonists promote adult neural progenitor cell (NPC) proliferation. We evaluated the protective effects of the selective CB1 receptor agonist ACEA, the selective CB2 receptor agonist JWH133 and the fatty-acid amide-hydrolase (FAAH) inhibitor URB597, which enhances endocannabinoid receptor activity, on NPC proliferation in rats with forced consumption of ethanol (10%) or sucrose liquid diets for 2 weeks. We performed immunohistochemical and stereological analyses of cells expressing the mitotic phosphorylation of his…
QPOs expected in rotating accretion flows around a supermassive black hole
2007
It is well known that rotating inviscid accretion flows with adequate injection parameters around black holes could form shock waves close to the black holes, after the flow passes through the outer sonic point and can be virtually stopped by the centrifugal force. We numerically examine such shock waves in 2D accretion flows with 10−5 to 106 Eddington critical accretion rates around a supermassive black hole with 106 M. As the results, the luminosities show QPO phenomena with modulations of a factor 2–3 and with quasi-periods of a few to several hours.
Long-term monitoring of mrk 501 for its very high energy γ emission and a flare in 2011 october
2012
"As one of the brightest active blazars in both X-ray and very high energy γ -ray bands, Mrk 501, is very useful for" "physics associated with jets from active galactic nuclei. The ARGO-YBJ experiment has monitored Mrk 501 for γ - rays above 0.3 TeV since 2007 November. The largest flare since 2005 was observed from 2011 October and lasted until about 2012 April. In this paper, a detailed analysis of this event is reported. During the brightest γ -ray flaring episodes from 2011 October 17 to November 22, an excess of the event rate over 6σ is detected by ARGO-YBJ in the direction of Mrk 501, corresponding to an increase of the γ -ray flux above 1 TeV by a factor of 6.6 ± 2.2 from its steady…
Dissipative Processes and Their Role in the Evolution of Radio Galaxies
2019
Particle acceleration in relativistic jets to very high energies occurs at the expense of the dissipation of magnetic or kinetic energy. Therefore, understanding the processes that can trigger this dissipation is key to the characterization of the energy budgets and particle acceleration mechanisms at action in active galaxies. Instabilities and entrainment are two obvious candidates to trigger dissipation. On the one hand, supersonic, relativistic flows threaded by helical fields, as expected from the standard formation models of jets in supermassive black-holes, are unstable to a series of magnetohydrodynamical instabilities, such as the Kelvin-Helmholtz, current-driven, or possibly the p…