Search results for " meta-analysis."

showing 5 items of 165 documents

Comparison of 99mTc-Labeled Colloid SPECT/CT and Planar Lymphoscintigraphy in Sentinel Lymph Node Detection in Patients with Melanoma: A Meta-Analysis

2020

We compared the detection rate (DR) for sentinel lymph nodes (SLNS), the number of SLNs and the subjects with additional SLNs of single-photon emission computed tomography (SPECT/CT) and planar lymphoscintigraphy (PL) in patients with melanoma. Furthermore, we evaluated the impact of SPECT/CT on surgical plans. Articles containing head-to-head comparisons between SPECT/CT and PL were searched in Pubmed/MEDLINE and Scopus. The literature search was updated until December 31st, 2019. DR was calculated on a per-patient-based analysis; the studies were pooled by their odds ratios (ORs) with a random effects model to assess the significance of difference (p < 0.05). The number of additional S…

planar lymphoscintigraphySentinel lymph nodelcsh:MedicineSingle-photon emission computed tomography030218 nuclear medicine & medical imaging03 medical and health sciences0302 clinical medicinesentinel lymph node99mTc-labeled colloidsmedicinemelanomamedicine.diagnostic_testbusiness.industryMelanomalcsh:RGeneral MedicineOdds ratiomedicine.diseaseConfidence intervalbody regionsmeta-analysis<sup>99m</sup>Tc-labeled colloids030220 oncology & carcinogenesisRelative riskMeta-analysis99mTc-labeled colloids; melanoma; meta-analysis; planar lymphoscintigraphy; sentinel lymph node; single photon emission/computed tomographysingle photon emission/computed tomographyNuclear medicinebusinessEmission computed tomographyJournal of Clinical Medicine
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Systematic review and exploratory meta-analysis of the efficacy, safety, and biological effects of psychostimulants and atomoxetine in patients with …

2019

ObjectiveOur aim was to summarize the efficacy and safety of atomoxetine, amphetamines, and methylphenidate in schizophrenia.MethodsWe undertook a systematic review, searching PubMed/Scopus/Clinicaltrials.gov for double-blind, randomized, placebo-controlled studies of psychostimulants or atomoxetine in schizophrenia published up to 1 January 2017. A meta-analysis of outcomes reported in two or more studies is presented.ResultsWe included 22 studies investigating therapeutic effects of stimulants (k=14) or measuring symptomatic worsening/relapse prediction after stimulant challenge (k=6). Six studies of these two groups plus one additional study investigated biological effects of psychostimu…

safetymedicine.medical_specialtyPsychosismedicine.medical_treatmentefficacyamphetamineSchizoaffective disorderAtomoxetine Hydrochloridemeta-analysi03 medical and health sciencesExecutive Function0302 clinical medicinesystematic reviewInternal medicinemedicineHumansAttentionAmphetamineProblem Solvingbusiness.industryMethylphenidateAtomoxetineAmphetaminesrelapse predictorstimulantmedicine.disease030227 psychiatryStimulantPsychiatry and Mental healthMemory Short-Termamphetamine atomoxetine efficacy meta-analysis methylphenidate relapse predictor safety schizophrenia stimulants systematicn reviewPsychotic DisordersSchizophreniaMeta-analysisMethylphenidateSchizophreniaNeurology (clinical)businessatomoxetine030217 neurology & neurosurgerymedicine.drugAntipsychotic Agents
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Systematic review and meta-analysis of the efficacy and safety of minocycline in schizophrenia

2017

ObjectiveOur aim was to perform an updated systematic review and meta-analysis on the efficacy and safety of adjunctive minocycline as a treatment of schizophrenia.MethodsWe conducted a PubMed/Scopus database search from inception to 3 February 2016 for randomized, placebo-controlled trials (RCTs), open non-randomized studies, and case reports/series evaluating minocycline in patients with schizophrenia. Random-effects meta-analysis of positive, negative, depressive, and cognitive symptom rating scales, discontinuation and adverse effects rates calculating standardized mean difference (SMD), and risk ratios±95% confidence intervals (CI95%) were calculated.ResultsSix RCTs were eligible (mino…

safetymedicine.medical_specialtyefficacyMinocyclinePlacebometa-analysi03 medical and health sciences0302 clinical medicinesystematic reviewInternal medicineefficacy; meta-analysis; Minocycline; safety; schizophrenia; systematic review; Neurology (clinical); Psychiatry and Mental HealthMedicineHumansRandomized Controlled Trials as TopicPositive and Negative Syndrome Scalebusiness.industryMinocycline schizophrenia efficacy safety meta-analysis systematic reviewConfidence interval030227 psychiatryDiscontinuationAnti-Bacterial Agentsmeta-analysisschizophreniaTolerabilityStrictly standardized mean differencePsychiatry and Mental HealthMeta-analysisAdjunctive treatmentNeurology (clinical)business030217 neurology & neurosurgeryAntipsychotic Agents
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Large-scale genotyping identifies 41 new loci associated with breast cancer risk

2013

Journal article Breast cancer is the most common cancer among women. Common variants at 27 loci have been identified as associated with susceptibility to breast cancer, and these account for ~9% of the familial risk of the disease. We report here a meta-analysis of 9 genome-wide association studies, including 10,052 breast cancer cases and 12,575 controls of European ancestry, from which we selected 29,807 SNPs for further genotyping. These SNPs were genotyped in 45,290 cases and 41,880 controls of European ancestry from 41 studies in the Breast Cancer Association Consortium (BCAC). The SNPs were genotyped as part of a collaborative genotyping experiment involving four consortia (Collaborat…

signaling pathwayGenotypingGenotypeSingle-nucleotide polymorphismGenome-wide association studyBreast NeoplasmsconsortiumBiologyBreast Neoplasms; Case-Control Studies; Cooperative Behavior; Female; Gene-Environment Interaction; Genetic Loci; Genome-Wide Association Study; Genotype; Humans; Meta-Analysis as Topic; Polymorphism Single Nucleotide; Risk Factors; Genetic Predisposition to Disease; GeneticsPolymorphism Single NucleotideArticle03 medical and health sciences0302 clinical medicineBreast cancerSDG 3 - Good Health and Well-beingMeta-Analysis as TopicRisk FactorsGenotypecommon variantsexpressionGeneticsmedicineHumansGenetic Predisposition to DiseasePolymorphismCooperative BehaviorgeneGenotypinghormone-related protein030304 developmental biologyGenetic associationGenetics0303 health sciencesBreast cancer susceptibilityCancerSingle Nucleotidemedicine.diseaseconfer susceptibilitysusceptibility loci3. Good health14q24.1 rad51l1TOX3Genetic Loci030220 oncology & carcinogenesisCase-Control Studiesgenome-wide associationFemaleGene-Environment InteractionGenome-Wide Association Study
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Workaholism and Work Engagement: How Are They Similar? How Are They Different? A Meta-Analysis of Their Relation

2018

Workaholism and work engagement can be depicted, respectively, as the pathological and the healthy form of heavy work investment. The former has been described as an addiction to work, yielded by the combination of excessive working hours and compulsive working style, whilst the latter has recently been introduced in workplace health literature as a pleasant mental state consisting of vigor, dedication, and absorption. In spite of their different definitions and outcomes on individual and organizational life, workaholism and work engagement are not clearly and adequately distinguished by scholars and researchers, since these two constructs seem to show some overlapping features. The aim of …

workaholism engagement meta-analysisSettore M-PSI/06 - Psicologia Del Lavoro E Delle Organizzazioni
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