Search results for " methodology."
showing 10 items of 520 documents
ECTRIMS/EAN guideline on the pharmacological treatment of people with multiple sclerosis.
2018
Background and purpose: Multiple sclerosis (MS) is a complex disease of the central nervous system. As new drugs are becoming available, knowledge on diagnosis and treatment must continuously evolve. There is therefore a need for a reference tool compiling current data on benefit and safety, to aid professionals in treatment decisions and use of resources across Europe. The European Committee of Treatment and Research in Multiple Sclerosis (ECTRIMS) and the European Academy of Neurology (EAN) have joined forces to meet this need. The objective was to develop an evidence-based clinical practice guideline for the pharmacological treatment of people with MS to guide healthcare professionals in…
Health-Related Quality of Life Is Severely Affected in Primary Orthostatic Tremor
2018
International audience; Background: Primary orthostatic tremor (POT) is a movement disorder characterized by unsteadiness upon standing still due to a tremor affecting the legs. It is a gradually progressive condition with limited treatment options. Impairments in health-related quality of life (HQoL) seem to far exceed the physical disability associated with the condition.Methods: A multi-center, mixed-methodology study was undertaken to investigate 40 consecutive patients presenting with POT to four movement disorder centers in France. HQoL was investigated using eight quantitative scales and a qualitative study which employed semi-structured interviews. Qualitative data were analyzed wit…
Endocrine Disruptors and Autism Spectrum Disorder in Pregnancy: A Review and Evaluation of the Quality of the Epidemiological Evidence
2018
Exposure to environmental contaminants during pregnancy has been linked to adverse health outcomes later in life. Notable among these pollutants are the endocrine disruptors chemicals (EDCs), which are ubiquitously present in the environment and they have been measured and quantified in the fetus. In this systematic review, our objective was to summarize the epidemiological research on the potential association between prenatal exposure to EDCs and Autism Spectrum Disorder (ASD) published from 2005 to 2016. The Navigation Guide Systematic Review Methodology was applied. A total of 17 studies met the inclusion criteria for this review, including: five cohorts and 12 case-control. According t…
La teoría del cambio: una herramienta para la planificación y la evaluación participativa en salud comunitaria
2020
Resumen: Existe un creciente interés por encontrar respuestas innovadoras para evaluar intervenciones complejas en salud pública. En esta nota metodológica, se presenta la teoría del cambio como una herramienta útil para facilitar tanto la planificación como la evaluación de intervenciones en promoción de la salud comunitaria. Una teoría del cambio es una representación visual de cómo funciona un programa o una intervención, en la que se identifican sus diferentes componentes y cómo cada elemento se vincula con otro: cuáles son sus objetivos, los resultados esperados y a través de qué acciones se pretenden alcanzar. Es una herramienta de investigación aplicada a la práctica que se desarroll…
Evaluating the statistical methodology of randomized trials on dentin hypersensitivity management
2017
The present study aimed to evaluate the characteristics and quality of statistical methodology used in clinical studies on dentin hypersensitivity management. An electronic search was performed for data published from 2009 to 2014 by using PubMed, Ovid/MEDLINE, and Cochrane Library databases. The primary search terms were used in combination. Eligibility criteria included randomized clinical trials that evaluated the efficacy of desensitizing agents in terms of reducing dentin hypersensitivity. A total of 40 studies were considered eligible for assessment of quality statistical methodology. The four main concerns identified were i) use of nonparametric tests in the presence of large samples…
The Subjective Social Value of Education Construct: CrossValidation between School and University Teachers
2016
La Educación posee un valor social evidente que puede presentarse mediante indicadores de evaluación socio-educativos. Si bien la relación entre contexto escolar y rendimiento es evidente en diversos países, esta relación va perdiendo consistencia en los últimos años; ya que aparecen sectores estudiantiles que superan las predicciones académicas esperadas. Para ello, se estudia el Valor Social Subjetivo de la Educación en función de dos grupos docentes –escuela y universidad–. La metodología es complementaria a través de comités de expertos/as y validación cruzada de constructo. Se realizan análisis sobre dos escalas –relevancia y susceptibilidad de cambio– y entre dos muestras diferenciada…
Research Perspectives: Reconsidering the Role of Research Method Guidelines for Interpretive, Mixed Methods, and Design Science Research
2021
Information systems (IS) scholars have proposed guidelines for interpretive, mixed methods, and design science research in IS. Because many of these guidelines have also been suggested for evaluating what good or rigorous research is, they may be used as a checklist in the review process. In this paper, we raise the question: To what extent do research guidelines for interpretive, mixed methods, and design science research offer evidence that they can be used to evaluate the quality of research. We argue that scholars can use these guidelines to evaluate what good research is if there is compelling evidence that they lead to certain good research outcomes. We use three well-known sets of gu…
Teollisten perheyritysten kasvudynamiikan systeemiteoreettinen tarkastelu
2004
Evaluation of Innovation Statistics Data Quality Dimensions.
2017
Promocijas darbā analizēta praktiskā situācija statistikas par inovācijām vākšanas un apstrādes procesā Latvijā, tiek apskatīta statistikas par inovācijām metodoloģija un tās pielietošanas prakse Latvijā, īpašu uzmanību pievēršot Latvijas inovāciju sistēmas īpatnībām. Pētījumā izstrādātās Latvijas inovāciju vadības un informācijas plūsmas sistēmas ietvaros tiek pamatots informatīvā atbalsta nozīmīgums lēmumu pieņemšanā. Balstoties uz Datu kvalitātes dimensiju novērtēšanas metodiku, veikts inovāciju statistikas datu kvalitātes novērtējums Latvijā. Ir izstrādāta un aprobēta Iteratīvā metode neraksturīgo punktu ietekmes mazināšanai. Pētījuma ietvaros tiek aplūkoti statistikas par inovācijām kv…
Increasing Yield and Antioxidative Performance of Litchi Pericarp Procyanidins in Baked Food by Ultrasound-Assisted Extraction Coupled with Enzymatic…
2018
Extraction with organic solvents is a traditional method to isolate bioactive compounds, which is energy-wasting and time-consuming. Therefore, enzyme and ultrasound treatments were combined to assist the extraction of oligomeric procyanidins from litchi pericarp (LPOPC), as an innovative approach to replace conventional extraction methods. Under optimum conditions (enzyme concentration 0.12 mg/mL, ultrasonic power 300 W, ultrasonic time 80 min, and liquid/solid ratio 10 mL/g), the yield of LPOPC could be improved up to 13.5%. HPLC analysis indicated that the oligomeric procyanidins (OPC) content of LPOPC from proposed extraction was up to 89.6%, mainly including (&minus