Search results for " migration"

Border Maps. (Counter-)cartographies of the Mediterranean

2020

Negli ultimi decenni il Mediterraneo è stato progressivamente tra- sformato in una frontiera liquida, uno spazio in cui le tecnologie di governo della mobilità si imprimono violentemente sui corpi di coloro i quali cercano di raggiungere l’Europa. Nonostante la rap- presentazione di flussi ed eventi migratori rappresenti una sfida per la cartografia e la sua geometria statica di confine, numerosi sono i tentativi recenti di utilizzo del linguaggio cartografico per rappre- sentare quel che accade alle frontiere meridionali d’Europa, specie nell’ambito della cartografia critica e radicale. Questo intervento si propone di esplorare la relazione fra eventi migratori e pratiche di (counter-)mapp…

Performance Analysis of Memory Cloning Solutions in Mobile Edge Computing

2018

This paper deals with the problem of service migration in the emerging scenarios of Mobile Edge Computing. Mobile edge computing is achieved by moving the traditional cloud infrastructures, exploited by many today applications, close to the network edge in order to reduce the response times in the so called tactile-internet. However, because of user mobility, such an application architecture may pose the problem of service migration in case of handover from one server site to another. After introducing the current solutions for dealing with service migration and, in particular, the approaches based on service decomposition into multiple layers, we quantify the migration time and the service…

1,2,4-Oxadiazole Topsentin Analogs with Antiproliferative Activity against Pancreatic Cancer Cells, Targeting GSK3β Kinase.

2021

A new series of topsentin analogs, in which the central imidazole ring of the natural lead was replaced by a 1,2,4- oxadiazole moiety, was efficiently synthesized. All derivatives were pre-screened for antiproliferative activity against the National Cancer Institute (NCI-60) cell lines panel. The five most potent compounds were further investigated in various pancreatic ductal adenocarcinoma (PDAC) cell lines, including SUIT-2, Capan-1, and Panc-1 cells, eliciting EC50 values in the micromolar and sub-micromolar range, associated with significant reduction of cell migration. These remarkable results might be explained by the effects of these new topsentin analogues on epithelial-to-mesenchy…

2014

Oligodendrocytes are the myelinating glial cells of the central nervous system. In the course of brain development, oligodendrocyte precursor cells migrate, scan the environment and differentiate into mature oligodendrocytes with multiple cellular processes which recognize and ensheath neuronal axons. During differentiation, oligodendrocytes undergo dramatic morphological changes requiring cytoskeletal rearrangements which need to be tightly regulated. The non-receptor tyrosine kinase Fyn plays a central role in oligodendrocyte differentiation and myelination. In order to improve our understanding of the role of oligodendroglial Fyn kinase, we have identified Fyn targets in these cells. Pur…

Narrating Migration

2017

Numerous studies evidence how migration represents a critical event in the subject’s life (Akhtar , 1999; Baptiste , 1987; Scabini & Rossi , 2008). Such an event is characterised by various phases, some of which reflect the loss of culture, family of origin, language and some of which concern adaptation to the new environment (Hertz, 1981, 1993; Kaёs, 1993; Sluzky, 1992). To foster routes of growth and constructive interaction with the new environment, it is necessary for immigrants to strengthen the process of self-awareness. This is fundamental if learning is to be considered transformative (Freire, 1970). According to what is proposed in this paper, such a process of self-awareness i…

Identity, origin, and migration of peripheral glial cells in the Drosophila embryo.

2008

Glial cells are crucial for the proper development and function of the nervous system. In the Drosophila embryo, the glial cells of the peripheral nervous system are generated both by central neuroblasts and sensory organ precursors. Most peripheral glial cells need to migrate along axonal projections of motor and sensory neurons to reach their final positions in the periphery. Here we studied the spatial and temporal pattern, the identity, the migration, and the origin of all peripheral glial cells in the truncal segments of wildtype embryos. The establishment of individual identities among these cells is reflected by the expression of a combinatorial code of molecular markers. This allows…

Netrins guide migration of distinct glial cells in the Drosophila embryo

2010

Development of the nervous system and establishment of complex neuronal networks require the concerted activity of different signalling events and guidance cues, which include Netrins and their receptors. In Drosophila, two Netrins are expressed during embryogenesis by cells of the ventral midline and serve as attractant or repellent cues for navigating axons. We asked whether glial cells, which are also motile, are guided by similar cues to axons, and analysed the influence of Netrins and their receptors on glial cell migration during embryonic development. We show that in Netrin mutants, two distinct populations of glial cells are affected: longitudinal glia (LG) fail to migrate medially …

Neurogenesis in adult subventricular zone

2002

Much excitement has been generated by the identification of adult brain regions harboring neural stem cells and their continual generation of new neurons throughout life. This is an important departure from traditional views of the germinal potential of the postnatal brain. However, a more profound

L-selectin regulates human neutrophil transendothelial migration

2021

ABSTRACT The migration of circulating neutrophils towards damaged or infected tissue is absolutely critical to the inflammatory response. L-selectin is a cell adhesion molecule abundantly expressed on circulating neutrophils. For over two decades, neutrophil L-selectin has been assigned the exclusive role of supporting tethering and rolling – the initial stages of the multi-step adhesion cascade. Here, we provide direct evidence for L-selectin contributing to neutrophil transendothelial migration (TEM). We show that L-selectin co-clusters with PECAM-1 – a well-characterised cell adhesion molecule involved in regulating neutrophil TEM. This co-clustering behaviour occurs specifically during …

The evolution of the European Union law on the criminalization of humanitarian assistance to irregular migrants: From the council directive 2002/90/C…

2021

With the new Pact on Migration and Asylum, the European Commission published the Guidance C(2020) 6470 of 23 September 2020 on the implementation of EU rules on definition and prevention of the facilitation of unauthorised entry, transit and residence. The present contribution shows as this guidance proposes an interpretation of the article 1 of the Council Directive 2002/90/CE, which only partially meets the problem of the criminalization of humanitarian assistance to irregular migrants, since it has shortcomings both at material and at formal level. After an analysis concerning the guidance capacity to impact on the Court of Justice and national judges case-law, the article ends with some…