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showing 10 items of 747 documents

SNPs in bone-related miRNAs are associated with the osteoporotic phenotype

2017

AbstractBiogenesis and function of microRNAs can be influenced by genetic variants in the pri-miRNA sequences leading to phenotypic variability. This study aims to identify single nucleotide polymorphisms (SNPs) affecting the expression levels of bone-related mature microRNAs and thus, triggering an osteoporotic phenotype. An association analysis of SNPs located in pri-miRNA sequences with bone mineral density (BMD) was performed in the OSTEOMED2 cohort (n = 2183). Functional studies were performed for assessing the role of BMD-associated miRNAs in bone cells. Two SNPs, rs6430498 in the miR-3679 and rs12512664 in the miR-4274, were significantly associated with femoral neck BMD. Further, we…

0301 basic medicineconformation:Diseases::Wounds and Injuries::Fractures Bone::Hip Fractures [Medical Subject Headings]:Phenomena and Processes::Genetic Phenomena::Phenotype [Medical Subject Headings]Polimorfismo de nucleótido simpleGene ExpressionboneOsteoblastosDensidad ósea:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]Cohort StudiesGene Frequencysingle nucleotide polymorphismBone DensityBone cellOssosgeneticsFracturas osteoporóticasCells CulturedGeneticsBone mineralMicroARNsMultidisciplinarymicroRNAbiologyQalleleR:Diseases::Wounds and Injuries::Fractures Bone::Osteoporotic Fractures [Medical Subject Headings]clinical trialMiddle Agedcohort analysisPhenotypeHumanosFenotipmedicine.anatomical_structureCancellous BoneosteoblastMedicine:Diseases::Musculoskeletal Diseases::Bone Diseases [Medical Subject Headings]:Phenomena and Processes::Genetic Phenomena::Genotype [Medical Subject Headings]:Anatomy::Cells::Connective Tissue Cells::Osteoblasts [Medical Subject Headings]AlelosFenotipomusculoskeletal diseasesmedicine.medical_specialtyGenotypeScienceSingle-nucleotide polymorphismBiologychemistryPolymorphism Single NucleotideArticleBone and Bones:Anatomy::Musculoskeletal System::Skeleton::Bone and Bones::Cancellous Bone [Medical Subject Headings]03 medical and health sciencesCalcification PhysiologicInternal medicinemicroRNAmedicineHumanshumanproceduresAllele:Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome::Genome Components::Genes::Alleles [Medical Subject Headings]AllelesFemoral neckGenetic associationAgedcell culture:Phenomena and Processes::Musculoskeletal and Neural Physiological Phenomena::Musculoskeletal Physiological Phenomena::Bone Density [Medical Subject Headings]:Phenomena and Processes::Genetic Phenomena::Genetic Variation::Polymorphism Genetic::Polymorphism Single Nucleotide [Medical Subject Headings]OsteoblastsEnfermedades óseasFracturas de caderaComputational BiologyCuello femoral:Chemicals and Drugs::Nucleic Acids Nucleotides and Nucleosides::Antisense Elements (Genetics)::RNA Antisense::MicroRNAs [Medical Subject Headings]MicroRNAs030104 developmental biologyEndocrinologymulticenter studybone mineralizationNucleic Acid ConformationOsteoporosispathology:Anatomy::Musculoskeletal System::Skeleton::Bone and Bones::Bones of Lower Extremity::Leg Bones::Femur::Femur Neck [Medical Subject Headings]TranscriptomemetabolismGenotipoFractures
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Factors influencing serum 25-hydroxivitamin D levels and other bone metabolism parameters in healthy older women

2016

Objective: Older women have frequently low serum 25-hydroxivitamin D (25[OH]D) concentrations, high parathormone (PTH) levels and low bone mineral density (BMD) values. Endogenous synthesis, dietary habits, sunlight exposure and fat-mass-mediated storage may influence 25(OH)D levels and bone metabolism, but the relevance of these factors in the elderly has yet to be fully elucidated. We aimed to investigate the influence of dietary vitamin D intake and fat mass on serum 25(OH)D levels and bone metabolism in older women. Design: Cross-sectional. Setting: Community. Participants: 218 fit older women attending a biweekly mild fitness program. Measurements: Dietary habits was investigated throu…

0301 basic medicinemedicine.medical_specialtyBone densityMedicine (miscellaneous)030209 endocrinology & metabolism25-hydroxyvitamin D; bone metabolism; dietary vitamin D intake; elderly; fat mass; Medicine (miscellaneous); Nutrition and Dietetics; Geriatrics and Gerontologydietary vitamin D intakeelderlyNOBone remodeling03 medical and health scienceschemistry.chemical_compound0302 clinical medicineInternal medicinemedicineVitamin D and neurologyFemoral neckBone mineralHyperparathyroidism030109 nutrition & dieteticsNutrition and Dieteticsbusiness.industryfat massmedicine.disease25-hydroxyvitamin Dmedicine.anatomical_structureEndocrinologychemistry25-hydroxyvitamin D dietary vitamin D intake fat mass bone metabolism elderlyCalcifediolSecondary hyperparathyroidismbone metabolismGeriatrics and GerontologybusinessThe journal of nutrition, health & aging
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Consensus Statement on the Use of Bone Turnover Markers for Short-Term Monitoring of Osteoporosis Treatment in the Asia-Pacific Region

2019

Osteoporosis is a major health issue. By 2050, a greater than 2-fold increase in patients number with hip fractures will occur in Asia representing 50% of all hip fractures worldwide. For the Asia-Pacific (AP) region, more efforts on controlling osteoporosis and the subsequent fractures are crucial. Bone mineral density (BMD) by dual energy X-ray absorptiometry (DXA) is commonly used to diagnose osteoporosis and monitor osteoporosis treatment. However, the inconvenience, cost, limited availability of DXA and the delay in detection of BMD changes after treatment initiation support an important role for bone turnover markers (BTMs), as short-term tools to monitor therapy. With regards to low …

0301 basic medicinemedicine.medical_specialtyConsensusEndocrinology Diabetes and MetabolismOsteoporosis030209 endocrinology & metabolismBone resorption makerAsia pacific regionCollagen Type IBone remodeling03 medical and health sciences0302 clinical medicineN-terminal telopeptideBone DensityOsteoporosis treatmentHealth caremedicineHumansRadiology Nuclear Medicine and imagingOrthopedics and Sports MedicineIntensive care medicineReimbursementAnabolicsBone mineralddc:616Hip Fracturesbusiness.industryAnti-resorptivesmedicine.diseasePeptide FragmentsBone formation makerOsteoporosisBone Remodeling030101 anatomy & morphologybusinessBiomarkersProcollagen
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Cost-effectiveness of buffered soluble alendronate 70 mg effervescent tablet for the treatment of postmenopausal women with osteoporosis in Italy

2021

Summary The use of buffered soluble alendronate 70 mg effervescent tablet, a convenient dosing regimen for bisphosphonate therapy, seems a cost-effective strategy compared with relevant alternative treatments for postmenopausal women with osteoporosis aged 60 years and over in Italy. Introduction To assess the cost-effectiveness of buffered soluble alendronate (ALN) 70 mg effervescent tablet compared with relevant alternative treatments for postmenopausal osteoporotic women in Italy. Methods A previously validated Markov microsimulation model was adjusted to the Italian healthcare setting to estimate the lifetime costs (expressed in €2019) per quality-adjusted life-years (QALY) of buffered …

0301 basic medicinemedicine.medical_specialtyeconomic evaluationCost effectivenessCost-Benefit AnalysisEndocrinology Diabetes and Metabolismmedicine.medical_treatmentOsteoporosisUrology030209 endocrinology & metabolismAlendronate . Buffered soluble alendronate . Cost-effectiveness . Economic evaluation . Effervescent tablets . Osteoporosis . TreatmentAlendronate; Buffered soluble alendronate; Cost-effectiveness; Economic evaluation; Effervescent tablets; Osteoporosis; Treatment; Aged; Alendronate; Cost-Benefit Analysis; Female; Humans; Italy; Middle Aged; Observational Studies as Topic; Postmenopause; Quality-Adjusted Life Years; Tablets; Bone Density Conservation Agents; Osteoporosis; Osteoporosis Postmenopausal03 medical and health sciences0302 clinical medicinemedicineHumansEffervescent tabletOsteoporosis PostmenopausalAgedBone mineralPostmenopausal womenBone Density Conservation AgentstreatmentAlendronatebusiness.industrybuffered soluble alendronateMiddle AgedBisphosphonatemedicine.diseaseosteoporosisPostmenopauseObservational Studies as TopicDenosumabZoledronic acidItalyeffervescent tabletsPostmenopausalFemaleOriginal ArticleCost-effectivenessQuality-Adjusted Life Years030101 anatomy & morphologybusinessTabletsmedicine.drugOsteoporosis International
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Mineral essential elements for nutrition in different chocolate products

2016

In this work, the essential mineral nutritional elements in cocoa beans, in chocolates at different cocoa percentage (60,70,80 and 90%) and in milk chocolate are evaluated. Dark chocolates are confirmed as an excellent source of magnesium (252.2 mg/100 g) and iron (10.9 mg/100 g): in chocolate containing 90% cocoa, their content corresponds to, respectively, 67.0% and 80.3 of Nutrient Reference Values (NRV) in the European Union. The chocolate containing 90% cocoa is also a good source of zinc (3.5 mg/100 g), which is important for the immune system, and selenium (0.1 mg/100 g). Three main components suitable to explain the mineral concentrations are analyzed by factor analysis. The compone…

0301 basic medicinemineralFood HandlingIronDietarychemistry.chemical_elementZincmagnesiumFood handlingSelenium03 medical and health sciences0302 clinical medicineNutrientmedia_common.cataloged_instance030212 general & internal medicineFood scienceChocolate; cocoa; iron; magnesium; mineral; nutritional values; Cacao; Chocolate; Iron Dietary; Magnesium; Selenium; Trace Elements; Zinc; Food Handling; Nutritive Value; Food ScienceChocolateEuropean unionTrace Elementmedia_commonnutritional valueCacao030109 nutrition & dieteticsMineralSettore AGR/15 - Scienze E Tecnologie AlimentariTrace ElementsZincMilk ChocolatechemistrycocoaReference valuesnutritional valuesNutritive ValueIron DietarySeleniumFood ScienceInternational Journal of Food Sciences and Nutrition
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Past, Present and Future Perspectives on Halloysite Clay Minerals

2020

Halloysite nanotubes (HNTs), clay minerals belonging to the kaolin groups, are emerging nanomaterials which have attracted the attention of the scientific community due to their interesting features, such as low-cost, availability and biocompatibility. In addition, their large surface area and tubular structure have led to HNTs’ application in different industrial purposes. This review reports a comprehensive overview of the historical background of HNT utilization in the last 20 years. In particular it will focus on the functionalization of the surfaces, both supramolecular and covalent, following applications in several fields, including biomedicine, environmental science and catalysis.

2019-20 coronavirus outbreakCoronavirus disease 2019 (COVID-19)Surface PropertiesSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Pharmaceutical ScienceNanotechnologyReviewhalloysite nanotubesengineering.materialHalloysiteAnalytical Chemistrylcsh:QD241-441lcsh:Organic chemistryDrug DiscoveryPhysical and Theoretical ChemistryParticle SizeMineralsMolecular StructureOrganic ChemistrySettore CHIM/06 - Chimica Organicahistorical backgroundsupramolecular functionalizationChemistry (miscellaneous)engineeringMolecular MedicineClayClay mineralschemical modificationMolecules
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Thermomineral waters of Greece: geochemical characterization

2020

75 °C). In terms of pH most results vary from 5.5 to 823 °C) ii) warm (23 40 °C) iii) thermal (40 75 °C) and iv) hyperthermal (&gtfew springs show either very low pH (&lt10) proposing serpentinization processes. Regarding TDS concentrations collected waters can be subdivided into low salinity (up to 1.5 g/L) brackish (up to 20 g/L) and saline (up to 43 g/L). The medium high salinities can be justified by mixing with sea water and/or strong waterrock interaction processes. Isotope composition of O and H ranges from 12.7 to +2.7 ‰ SMOW and from 91 to +12 ‰ SMOW respectively and is generally comprised between the Global Meteoric Water Line and the East Mediterranean Meteoric Water Line. Only few water samples show a positive shift for δ18O possibly related to high temperature waterrock interaction processes. Carbon dioxide (18 997000 μmol/mol) or N2 (1100 989000 μmol/mol) or CH4 (&ltMany geothermal areas of Greece are located in regions affected by Miocene or Quaternary volcanism and in continental basins characterised by elevated heat flow. Moreover the majority of them is found along the coast as well as in islands of the Aegean Sea and thus thermal water is often brackish to saline due to marine intrusion into costal aquifer. In the present study almost 300 thermal and cold mineral water samples were collected along the Hellenic territory with their physicochemical parameters (temperature pH electrical conductivity and Eh) and the amount of bicarbonates (titration with 0.1N HCl) being determined in situ. Additionally gases found either in free or dissolved phase were sampled. Both water and gas samples were analysed at the INGVPa laboratories for major ions (Ion Chromatography) silica (Inductively Coupled Plasma Optical Emission Spectrometry) chemical composition of free and dissolved gases (Gas Chromatography) water isotopes (O and H) and carbon and helium isotopes of free and dissolved gases (Mass Spectrometry). The temperature of the investigated waters ranges from 6.5 to 98°C pH from 1.96 to 11.98 whilst Total Dissolved Solids (TDS) from 0.06 to 43 g/L. Based on the temperature parameter waters can be divided into four groups: i) cold (&lt0.5 913000 μmol/mol) are the prevailing gas species found in the studied sites. The δ13CCO2 values ranged from 20.1 to +8.5 ‰ whilst the isotope ratio of He from 0.21 to 6.71 R/RA.4) suggesting interaction with H2Srich gases or very high pH values (&gtSettore GEO/08 - Geochimica E Vulcanologia
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Effects of elastic-based exercise interventions on oxidative stress, bone health, body composition, neuromuscular strength and physical function in o…

2021

Antecedentes El envejecimiento de la población mundial es reconocido por la Organización Mundial de la Salud (OMS) como un problema principal debido a las discapacidades y comorbilidades relacionadas con este proceso, siendo las mujeres el género más afectado. Debido al deterioro y las consecuencias asociadas al envejecimiento, la actividad física y el ejercicio han demostrado ser estrategias eficaces para reducir el impacto del envejecimiento. Sin embargo, todavía se desconoce qué tipo de programa de entrenamiento podría ser el más eficaz para revertir los cambios deletéreos relacionados con la edad en mujeres mayores. En este sentido, el tipo de intensidad del entrenamiento y la modalidad…

:CIENCIAS DE LA VIDA::Biología humana [UNESCO]Variable resistanceUNESCO::CIENCIAS DE LA VIDA::Fisiología humanaHigh-velocity resistance trainingAdipose tissue:CIENCIAS DE LA VIDA::Fisiología humana ::Fisiología del movimiento [UNESCO]UNESCO::CIENCIAS DE LA VIDA::Fisiología humana ::Fisiología del movimiento:CIENCIAS MÉDICAS [UNESCO]:CIENCIAS DE LA VIDA [UNESCO]:CIENCIAS MÉDICAS ::Ciencias clínicas::Geriatría [UNESCO]:CIENCIAS DE LA VIDA::Fisiología humana [UNESCO]Older adultsUNESCO::CIENCIAS MÉDICASUNESCO::QUÍMICA::BioquímicaMuscle powerUNESCO::CIENCIAS DE LA VIDAUNESCO::CIENCIAS MÉDICAS ::Ciencias clínicas::GeriatríaBone mineral densityUNESCO::CIENCIAS DE LA VIDA::Biología humana:QUÍMICA::Bioquímica [UNESCO]
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Proximate Composition and Nutritional Value of Three Macroalgae: Ascophyllum nodosum, Fucus vesiculosus and Bifurcaria bifurcata

2017

Proximate composition (moisture, protein, lipid and ash content) and nutritional value (fatty acid, amino acid and mineral profile) of three macroalgae (Ascophyllum nodosum, Fucus vesiculosus and Bifurcaria bifurcate) were studied. Chemical composition was significantly (p < 0.001) different among the three seaweeds. In this regard, the B. bifurcata presented the highest fat content (6.54% of dry matter); whereas, F. vesiculosus showed the highest protein level (12.99% dry matter). Regarding fatty acid content, the polyunsaturated fatty acids (PUFAs) were the most abundant followed by saturated fatty acids (SFAs) and monounsaturated fatty acids (MUFAs). On the other hand, the three seawe…

<i>Ascophyllum nodosum</i>; <i>Fucus vesiculosus</i>; <i>Bifurcaria bifurcate</i>; seaweeds; fatty acid profile; amino acid content; minerals; chemical compositionBifurcaria bifurcatePharmaceutical ScienceFucus vesiculosusPhaeophytaArticleFatty Acids Monounsaturatedfatty acid profile0404 agricultural biotechnologyDrug DiscoveryBotanychemical compositionDry matterFood scienceAmino Acidslcsh:QH301-705.5Pharmacology Toxicology and Pharmaceutics (miscellaneous)Ascophyllumchemistry.chemical_classificationbiologyAscophyllum nodosumFatty AcidsFucus vesiculosusProteinsFatty acid04 agricultural and veterinary sciencesmineralsSeaweedbiology.organism_classificationLipids040401 food scienceBifurcariaAmino acidseaweedslcsh:Biology (General)chemistryamino acid contentFucusFatty Acids UnsaturatedFucusNutritive ValueAscophyllumPolyunsaturated fatty acidMarine Drugs
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Temperature effects on the IR absorption bands of hydroxyl and deuteroxyl groups in silica glass

2009

Abstract In this report we will show the changes of the band shape of the hydroxyl group (SiOH) infrared (IR) absorption band (∼3670 cm −1 ) in silica glass induced by lowering temperature in the range from 290 to 20 K. This band is considered as the overlap of several spectral components associated to the vibrational activity of hydroxyl groups in different bond configurations. By a suitable analysis of the experimental band profile in terms of different sub-bands, we studied the thermal evolution of each component and we reconsidered their assignations. For comparison we examined the SiOD absorption band (∼2710 cm −1 ) as a function of temperature as well. Our data can be interpreted as a…

Absorption spectroscopyInfraredChemistryHydrogen bondFTIR measurements Infrared properties Silica AerogelsAnalytical chemistryInfrared spectroscopyCondensed Matter PhysicsElectronic Optical and Magnetic MaterialsExtinction (optical mineralogy)Absorption bandMolecular vibrationThermalMaterials ChemistryCeramics and Composites
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