Search results for " mito."
showing 10 items of 892 documents
Physiological, morphological and metabolic changes in Tetrahymena pyriformis for the in vivo cytotoxicity assessment of metallic pollution: Impact on…
2007
Abstract The individual cytotoxicity of cadmium chloride, iron sulphate and chromium nitrate has been investigated by using the freshwater ciliate Tetrahymena pyriformis. The metabolic enzymes and antioxidant defense biomarkers were assessed. The results obtained reveal that their metal salts have perturbed the physiology and morphology of T. pyriformis. Also, the biomarkers assessed were sensitive to the presence of metal salts and this sensitivity was metal salt and dose dependant. To estimate the impact of their metal salts on mitochondria, we studied their effects in vivo and in vitro on the d -β-hydroxybutyrate dehydrogenase (BDH) (EC 1.1.1.30) inner mitochondrial membrane enzyme. The …
p38 MAPK: A dual role in hepatocyte proliferation through reactive oxygen species
2013
p38 MAPKs are important mediators of signal transduction that respond to a wide range of extracellular stressors such as UV radiation, osmotic shock, hypoxia, pro-inflammatory cytokines, and oxidative stress. The most abundant family member is p38α, which helps to couple cell proliferation and growth in response to certain damaging stimuli. In fact, increased proliferation and impaired differentiation are hallmarks of p38α-deficient cells. It has been reported that reactive oxygen species (ROS) play a critical role in cytokine-induced p38α activation. Under physiological conditions, p38α can function as a mediator of ROS signaling and either activate or suppress cell cycle progression depen…
One Enzyme, Two Functions
2010
The human enzyme paraoxonase-2 (PON2) has two functions, an enzymatic lactonase activity and the reduction of intracellular oxidative stress. As a lactonase, it dominantly hydrolyzes bacterial signaling molecule 3OC12 and may contribute to the defense against pathogenic Pseudomonas aeruginosa. By its anti-oxidative effect, PON2 reduces cellular oxidative damage and influences redox signaling, which promotes cell survival. This may be appreciated but also deleterious given that high PON2 levels reduce atherosclerosis but may stabilize tumor cells. Here we addressed the unknown mechanisms and linkage of PON2 enzymatic and anti-oxidative function. We demonstrate that PON2 indirectly but specif…
Codependencia y literatura : la codependencia en la antigüedad clásica
2000
Este artículo se escribe con la finalidad de profundizar sobre el origen del fenómeno adictivo de la codependencia. Para ello, se analiza la narrativa literaria mitológica de Eco, narrativa concebida como la metáfora por excelencia de la condición codependiente. El análisis literario hará emerger ciertas características familiares que se sitúan teóricamente en el origen del proceso adictivo codependiente, corroborando así hipótesis de trabajo.
Integrin α2β1 Mediates Isoform-Specific Activation of p38 and Upregulation of Collagen Gene Transcription by a Mechanism Involving the α2 Cytoplasmic…
1999
Two collagen receptors, integrins alpha1beta1 and alpha2beta1, can regulate distinct functions in cells. Ligation of alpha1beta1, unlike alpha2beta1, has been shown to result in recruitment of Shc and activation of the Ras/ERK pathway. To identify the downstream signaling molecules activated by alpha2beta1 integrin, we have overexpressed wild-type alpha2, or chimeric alpha2 subunit with alpha1 integrin cytoplasmic domain in human osteosarcoma cells (Saos-2) lacking endogenous alpha2beta1. The chimeric alpha2/alpha1 chain formed a functional heterodimer with beta1. In contrast to alpha2/alpha1 chimera, forced expression of alpha2 integrin resulted in upregulation of alpha1 (I) collagen gene …
El mito de la princesa: Blancanieves y la Bella Durmiente según Elfriede Jelinek
2011
Reescribir y reinterpretar cuentos tradicionales forma parte ya de una tradición literaria a la que no pocos autores se han sumado. El presente artículo ofrecerá un análisis de uno de estos intentos, llevado a cabo por la escritora austriaca Elfriede Jelinek. La autora ganadora del Premio Nobel de Literatura en 2004 publicó un año antes Dramas de princesas. La muerte y la doncella I-V, un conjunto de cinco obras concebidas como entreactos de otros espectáculos teatrales. De entre los modelos que la autora toma como referencia, los cuentos de hadas suponen el punto de partida para dos de los dramas, La muerte y la doncella I (Blancanieves) y La Muerte y la doncella II (La Bella Durmiente). E…
Ercole e il serpente. Figure di ricordo, modelli mitici, modelli etici nel "de beneficiis" di Seneca
2009
Methionine Cycle Rewiring by Targeting miR-873-5p Modulates Ammonia Metabolism to Protect the Liver from Acetaminophen
2022
Drug-induced liver injury (DILI) development is commonly associated with acetaminophen (APAP) overdose, where glutathione scavenging leads to mitochondrial dysfunction and hepatocyte death. DILI is a severe disorder without effective late-stage treatment, since N-acetyl cysteine must be administered 8 h after overdose to be efficient. Ammonia homeostasis is altered during liver diseases and, during DILI, it is accompanied by decreased glycine N-methyltransferase (GNMT) expression and S-adenosylmethionine (AdoMet) levels that suggest a reduced methionine cycle. Anti-miR-873-5p treatment prevents cell death in primary hepatocytes and the appearance of necrotic areas in liver from APAP-adminis…
Resveratrol post-transcriptionally regulates pro-inflammatory gene expression via regulation of KSRP RNA binding activity
2014
Resveratrol shows beneficial effects in inflammation-based diseases like cancer, cardiovascular and chronic inflammatory diseases. Therefore, the molecular mechanisms of the anti-inflammatory resveratrol effects deserve more attention. In human epithelial DLD-1 and monocytic Mono Mac 6 cells resveratrol decreased the expression of iNOS, IL-8 and TNF-α by reducing mRNA stability without inhibition of the promoter activity. Shown by pharmacological and siRNA-mediated inhibition, the observed effects are SIRT1-independent. Target-fishing and drug responsive target stability experiments showed selective binding of resveratrol to the RNA-binding protein KSRP, a central post-transcriptional regul…
La presencia de Groto en la poesía amorosa de Quevedo: Tres poemas de argumento mitológico
2013
A través de la comparación de tres poemas amorosos de Quevedo con otros tantos del autor italiano Luigi Groto, el presente trabajo pretende demostrar que la imitación o reelaboración quevediana de otros autores no es nunca mecánica sino que conlleva siempre la aportación de recursos originales que consiguen renovar la tradición. En particular, en los poemas analizados, cuyo elemento común es la presencia de personajes mitológicos, es posible averiguar cómo Quevedo, aunque se trate de poemas ‘serios', maneja el tema mitológico de manera poco convencional, relativizando y hasta rebajando las figuras míticas con el uso de un tono que si no llega a los extremos de la burlesca, tiene a vec…