Search results for " model"
showing 10 items of 16868 documents
Ensuring the Reliability of an Autonomous Vehicle
2017
International audience; In automotive applications, several components, offering different services, can be composed in order to handle one specific task (autonomous driving for example). Nevertheless, component composition is not straightforward and is subject to the occurrence ofbugs resulting from components or services incompatibilities for instance. Hence, bugs detection in component-based systems at thedesign level is very important, particularly, when the developed system concerns automotive applications supporting critical services.In this paper, we propose a formal approach for modeling and verifying the reliability of an autonomous vehicle system, communicatingcontinuously with of…
Political interest furthers partisanship in England, Scotland, and Wales
2016
ABSTRACTAccording to much of the literature, partisanship in Britain exercises little independent influence on the vote but merely reflects voters’ prospective and retrospective evaluations of the parties’ performance with regard to their management of the economy, national security, and public services. In this view, partisanship comes close to Fiorina’s model of a “running tally” of political experiences. Similarly, Dalton’s notion of “cognitive mobilization” suggests that seeking out political information should undermine both the need for and the likelihood of party identification. Applying Mixed Markov Latent Class Analysis to the British Election Study Panel 1997–2000, we challenge th…
The bearing capacity of footings on sand with a weak layer
2017
Minor details of the ground, such as thin weak layers, shear bands and slickensided surfaces, can substantially affect the behaviour of soil–footing and other geotechnical systems, despite their seeming insignificance. In this paper, the influence of the presence of a thin horizontal weak layer on the ultimate bearing capacity of a strip footing on dense sand is investigated by single-gravity tests on small-scale physical models of the soil–footing system. The test results show that the weak layer strongly influences both the failure mechanism and the ultimate bearing capacity if its depth is lower than about four times the footing width. It is found that the presence of a thin weak layer …
On the reactivation of a large landslide induced by rainfall in highly fissured clays
2018
Abstract The paper discusses the field investigations, geotechnical characterization and time evolution of horizontal displacements in a wide landslide. The latter, triggered by an earthquake occurring in September 2002, is located in Sicily and involves a thick body of stiff and highly fissured clays belonging to a Varicoloured Clay formation. In order to characterise the reactivation of landslide mechanisms induced by rainfall, a three-year monitoring programme (2008–2011) was implemented to measure rain, pore water pressures, and deep and superficial displacements. The monitoring data made it possible to recognize three distinct landslides, which evolve at variable rates in different dir…
Data Sources Handling for Emergency Management: Supporting Information Availability and Accessibility for Emergency Responders
2017
Information is an essential component for better emergency response. Although a lot of information being available at various places during any kind of emergency, many emergency responders (ERs) use only a limited amount of the available information. The reason for this is that the available information heterogeneously distributed, in different formats, and ERs are unable to get access to the relevant information. Moreover, without having access to the needed information, many emergency responders are not able to obtain a sufficient understanding of the emergency situation. Consequently, a lot of time is being used to search for the needed information and poor decisions may be made. Therefo…
Sustainable growth and environmental catastrophes
2017
Abstract In the standard AK growth model we introduce the threat of an ecological catastrophe and study the consequences for the economic variables in the long-run. We extend the basic framework by considering two environmental externalities: the first one is local and gives account of the marginal damage from emissions flow; the second one is aggregate, or global, and relates to the extreme damage which may happen if the accumulated stock of pollutants is on the threshold of a worldwide catastrophe. In this context dominated by market failures, we focus on the socially optimal solution and the search of conditions for sustainability. We identify the efficient balanced growth path, which ma…
Estimation of Location and Activation Time of Purkinje Myocardial Junctions from Sparse and Noisy Endocardial Electrical Samples
2017
The activation of the myocardial muscle is triggered by Purkinje-myocardial junctions (PMJs), which are the terminal sites of the specialised cardiac conduction system (CCS). Obtaining the location of the PMJs and other sources of endocardial ectopic activity would be desirable for building computer models of cardiac electrophysiology and planning ablation interventions. We present a method to estimate the location and activation times of endocardial electrical sources in a 3D model of the ventricles. The algorithm requires a set of discrete electrical samples on the endocardium, which can include errors in location and activation time. The estimated sources are properly placed with a locat…
Visualization of Simulated Arrhythmias due to Gap Junctions
2018
New computational models are able to simulate details of cardiac cell networks. Their results allow a better understanding of the functionality of the heart and suggest possible actions to reduce non-fatal premature beats that can give rise to serious diseases. We developed a user-friendly interface to organize Neuron simulations and to present in real-time a three-dimensional representation of the electrical activity due to the gap junctions which interconnect the cells inside cardiac tissues. All physiological parameters were set according to real experimental observations and compared against different types of arrhythmias, retrieved from the Physionet Data Base.
Investigation of Isoindolo[2,1-a] quinoxaline-6-imines as Topoisomerase I Inhibitors with Molecular Modeling Methods
2017
Background: Isoindolo[2,1-alpha] quinoxalines constitute an important class of compounds which demonstrated potent antiproliferative activity against different human tumor cell lines and topoisomerase I inhibitors. In particular, their water soluble imine or iminium salts recently synthesized showed potent growth inhibitory effect on NCI-60 tumor cell line panel and biological studies performed on the most active compounds demonstrated that they cause DNA damage via topoisomerase I poisoning. Objective: Herein, we investigate with molecular modeling methods, the common features responsible for topoisomerase I inhibition of the water-soluble isoindolo[2,1-alpha] quinoxalin-6-imines, by compa…
Multiplicative decomposition of the scaling effect in the Mixed Assessor Model into a descriptor-specific and an overall coefficients
2016
Abstract In 1994, Brockhoff and Skovgaard presented the so-called assessor model, including a “scaling coefficient” expressing the predisposition of a panelist to spread more or less his scores than the panel on a given sensory descriptor. This paper discusses potential scaling causes, and then proposes a decomposition of the scaling coefficient into two components: (i) an overall scaling coefficient, independent of the descriptors, expressing a psychological trend of the panelist towards the scoring task in general; (ii) a corrected scaling coefficient for each descriptor, expressing specific sensitivity of the panelist to the descriptor. Applied to 187 sensory datasets, this decomposition…