Search results for " modeling"
showing 10 items of 2411 documents
Students’ Perceptions of Teachers’ Corrective Feedback, Basic Psychological Needs and Subjective Vitality: A Multilevel Approach
2020
The way students perceive corrective feedback has repercussions on what they learn and think. Based on the self-determination theory, the aim of this study is to test a model of multilevel mediation that examines the relationships between the perception of corrective feedback with its degree of acceptance (perceived legitimacy) at the team level and the subjective vitality of students at the individual level, mediated by the satisfaction of the three psychological needs, in the context of physical education. The participants were 742 students aged between 10 and 13 years old (52.6% men, 47.4% women) in 29 physical education groups. The results of the multilevel structural equation modeling …
Data from: Genome architecture enables local adaptation of Atlantic cod despite high connectivity
2017
Adaptation to local conditions is a fundamental process in evolution; however, mechanisms maintaining local adaptation despite high gene flow are still poorly understood. Marine ecosystems provide a wide array of diverse habitats that frequently promote ecological adaptation even in species characterized by strong levels of gene flow. As one example, populations of the marine fish Atlantic cod (Gadus morhua) are highly connected due to immense dispersal capabilities but nevertheless show local adaptation in several key traits. By combining population genomic analyses based on 12K single nucleotide polymorphisms with larval dispersal patterns inferred using a biophysical ocean model, we show…
Mechanistic Modeling and Multiscale Applications for Precision Medicine: Theory and Practice
2020
Drug research, therapy development, and other areas of pharmacology and medicine can benefit from simula- tions and optimization of mathematical models that contain a mathematical description of interactions between systems elements at the cellular, tissue, organ, body, and population level. This approach is the foundation of systems medicine and precision medicine. Here, simulated experiments are performed with computers (in silico) first, and they are then replicated through lab experiments (in vivo or in vitro) or clinical studies. In turn, these experiments and studies can be used to validate or improve the models. This iterative loop of dry and wet lab work is successful when biomedica…
Synthesis and biological evaluation of sphingosine kinase 2 inhibitors with anti-inflammatory activity.
2019
The synthesis of inhibitors of SphK2 with novel structural scaffolds is reported. These compounds were designed from a molecular modeling study, in which the molecular interactions stabilizing the different complexes were taken into account. Particularly interesting is that 7‐bromo‐2‐(2‐phenylethyl)‐2,3,4,5‐tetrahydro‐1,4‐epoxynaphtho[1,2‐b]azepine, which is a selective inhibitor of SphK2, does not exert any cytotoxic effects and has a potent anti‐inflammatory effect. It was found to inhibit mononuclear cell adhesion to the dysfunctional endothelium with minimal impact on neutrophil–endothelial cell interactions. The information obtained from our theoretical and experimental study can be us…
On the Use of XML in Medical Imaging Web-Based Applications
2016
The rapid growth of digital technology in medical fields over recent years has increased the need for applications able to manage patient medical records, imaging data, and chart information. Web-based applications are implemented with the purpose to link digital databases, storage and transmission protocols, management of large volumes of data and security concepts, allowing the possibility to read, analyze, and even diagnose remotely from the medical center where the information was acquired. The objective of this paper is to analyze the use of the Extensible Markup Language (XML) language in web-based applications that aid in diagnosis or treatment of patients, considering how this proto…
Electrocardiographic Indices of Left Ventricular Hypertrophy and Repolarization Phase Share the Same Genetic Influences: A Twin Study
2009
Background: Both left ventricular hypertrophy (LVH) and repolarization phase (RP) are known to be attributable to genetic influences, but less is known whether they share same genetic influences. The aim of this study was to investigate to what extent individual differences in electrocardiographic (ECG) LVH and RP are explained by genetic and environmental influences and whether these influences are shared between these two traits. Methods: Resting ECG recordings were obtained from 186 monozygotic and 203 dizygotic female twin individuals, aged 63 to 76 years. Latent factors, called LVH and RP, were formed to condense the information obtained from LVH indices (Cornell voltage and Cornell pr…
General Adaption Framework
2005
Integration of heterogeneous applications and data sources into an interoperable system is one of the most relevant challenges for many knowledge-based corporations nowadays. Development of a global environment that would support knowledge transfer from human experts to automated Web services, which are able to learn, is a very profit-promising and challenging task. The domain of industrial maintenance is not an exception. This paper outlines in detail an approach for adaptation of heterogeneous Web resources into a unified environment as a first step toward interoperability of smart industrial resources, where distributed human experts and learning Web services are utilized by various devi…
Web Personalization : The State of the Art and Future Avenues for Research and Practice
2016
Provide a review of current developments in web personalization.Show evolution toward more complex contextualized approaches.Identify research gaps in web personalization and in six specific research streams.Propose web personalization to be complemented with interpolated approaches. Although web personalization has been examined by earlier literature reviews, an updated analysis of recent advances in the field is needed. The authors extend prior reviews of web personalization by discussing current areas of interest, research gaps and future directions. A literature review of the top 20 marketing and information systems journals published during the period of 2005-2015 (May) shows active re…
Towards a Framework for Agent-Enabled Semantic Web Service Composition
2004
The article presents the framework for agent-enabled dynamic Web service composition. The core of the methodology is the new understanding of a Web service as an agent capability having proper ontological description. It is demonstrated how diverse Web services may be composed and mediated by dynamic coalitions of software agents collaboratively performing tasks for service requestors. Middle Agent Layer is introduced to conduct service request to task transformation, agent-enabled cooperative task decomposition and performance. Discussed are the formal means to arrange agents’ negotiation, to represent the semantic structure of the task-activity-service hierarchy and to assess fellow-agent…
An Integrated Framework for Web Services Orchestration
2009
International audience; Currently, Web services give place to active research and this is due both to industrial and theoretical factors. On one hand, Web services are essential as the design model of applications dedicated to the electronic business. On the other hand, this model aims to become one of the major formalisms for the design of distributed and cooperative applications in an open environment (the Internet). In this article, the authors will focus on two features of Web services. The first one concerns the interaction problem: given the interaction protocol of a Web service described in BPEL, how to generate the appropriate client? Their approach is based on a formal semantics fo…