Search results for " modelling."
showing 10 items of 983 documents
Surface Characteristics of Machined Polystyrene with 3D Printed Thermoplastic Tool
2020
An effort is made in this work to appraise the surface characteristics of machined expandable polystyrene (EPS) with a novel 3D printed thermoplastic acrylonitrile-butadiene-styrene (ABS) tool. Linear grooves on EPS were made on a vertical milling machine that was modified to conduct experiments in the laboratory. The tests were designed as per the Taguchi L9 based factorial design of experimentation while varying process parameters such as depth of cut, spindle speed, and feed rate. The machining responses dimensional accuracy and surface roughness of the machined grooves were studied. Furthermore, the surface topography of the machined specimens was considered to investigate the mechanism…
A Methodology for Modeling and Optimizing Social Systems
2020
[EN] A system methodology for modeling and optimizing social systems is presented. It allows constructing dynamical models formulated stochastically, i.e., their results are given by confidence intervals. The models provide optimal intervention ways to reach the stated objectives. Two optimization methods are used: (1) to test strategies and scenarios and (2) to optimize with a genetic algorithm. The application case presented is a small nonformal education Spanish business. First, the model is validated in the 2008-2012 period, and subsequently, the optimal way to obtain a maximum profit in the 2013-2025 period is obtained using the two methods.
Intelligent agents for feature modelling in computer aided design
2017
Abstract CAD modelling can be referred to as the process of generating an integrated multiple view model as a representation of multiple views of engineering design. In many situations, a change in the model of one view may conflict with the models of other views. In such situations, the model of some views needs to be adapted in order to make all models consistent. Thus, CAD models should be capable of adapting themselves to new situations. Recently, agent based technologies have been considered in order to increase both knowledge level and intelligence of real and virtual objects. The contribution of this paper consists in introducing the intelligent agents in intelligent CAD modelling. T…
Thermo-Hydraulic Modelling and Experimental Validation of an Electro-Hydraulic Compact Drive
2021
Electro-hydraulic compact drives (ECDs) are an emerging technology for linear actuation in a wide range of applications. Especially within the low power range of 5–10 kW, the plug-and-play capability, good energy efficiency and small space requirements of ECDs render this technology a promising alternative to replace conventional valve-controlled linear drive solutions. In this power range, ECDs generally rely on passive cooling to keep oil and system temperatures within the tolerated range. When expanding the application range to larger power classes, passive cooling may not be sufficient. Research investigating the thermal behaviour of ECDs is limited but indeed required for a successful …
Additively manufactured textiles and parametric modelling by generative algorithms in orthopaedic applications
2020
Purpose The purpose of this paper is to implement a new process aimed at the design and production of orthopaedic devices fully manufacturable by additive manufacturing (AM). In this context, the use of generative algorithms for parametric modelling of additively manufactured textiles (AMTs) also has been investigated, and new modelling solutions have been proposed. Design/methodology/approach A new method for the design of customised elbow orthoses has been implemented. In particular, to better customise the elbow orthosis, a generative algorithm for parametric modelling and creation of a flexible structure, typical of an AMT, has been developed. Findings To test the developed modelling a…
A numerical model for pre-monitoring design of historical colonnade courtyards: The case study of chiaramonte palace in palermo
2016
This paper proposes a numerical model that can be used for theoretical and experimental dynamic characterization of historical colonnade courtyards. Such an architectural element appears often in buildings of historical heritage and, especially under seismic excitation, it represents the most vulnerable structural part. Therefore, it is very important to have reliable as well as simple models available for vulnerability analysis, to evaluate different reinforcing systems if needed, or to plan dynamic characterization tests or monitoring campaigns, as in the present case. Chiaramonte Palace, a wonderful example of the historical heritage of Palermo, is investigated as case study. Firstly, a …
On the reactivation of a large landslide induced by rainfall in highly fissured clays
2018
Abstract The paper discusses the field investigations, geotechnical characterization and time evolution of horizontal displacements in a wide landslide. The latter, triggered by an earthquake occurring in September 2002, is located in Sicily and involves a thick body of stiff and highly fissured clays belonging to a Varicoloured Clay formation. In order to characterise the reactivation of landslide mechanisms induced by rainfall, a three-year monitoring programme (2008–2011) was implemented to measure rain, pore water pressures, and deep and superficial displacements. The monitoring data made it possible to recognize three distinct landslides, which evolve at variable rates in different dir…
Improving risk assessments in conservation ecology
2019
Conservation efforts and management decisions on the living environment of our planet often rely on the results from statistical models. Yet, these models are imperfect and quantification of risk associated with the estimate of management-relevant quantities becomes crucial in providing robust advice. Here we demonstrate that estimates of risk themselves could be substantially biased but by combining data fitting with an extensive simulation–estimation procedure, one can back-calculate the correct values. We apply the method to 627 time series of population abundance across four taxa using the Gompertz state-space model as an example. We find that the risk of large bias in population status…
Design, synthesis and preliminary evaluation of dopamine-amino acid conjugates as potential D1 dopaminergic modulators.
2016
Abstract The dopamine-amino acid conjugate DA-Phen was firstly designed to obtain a useful prodrug for the therapy of Parkinson's disease, but experimental evidence shows that it effectively interacts with D1 dopamine receptors (D1DRs), leading to an enhancement in cognitive flexibility and to the development of adaptive strategies in aversive mazes, together with a decrease in despair-like behavior. In this paper, homology modelling, molecular dynamics, and site mapping of D1 receptor were carried out with the aim of further performing docking studies on other dopamine conjugates compared with D1 agonists, in the attempt to identify new compounds with potential dopaminergic activity. Two n…
A Physiology-Based Model of Human Bile Acid Metabolism for Predicting Bile Acid Tissue Levels After Drug Administration in Healthy Subjects and BRIC …
2019
Drug-induced liver injury (DILI) is a matter of concern in the course of drug development and patient safety, often leading to discontinuation of drug-development programs or early withdrawal of drugs from market. Hepatocellular toxicity or impairment of bile acid (BA) metabolism, known as cholestasis, are the two clinical forms of DILI. Whole-body physiology-based modelling allows a mechanistic investigation of the physiological processes leading to cholestasis in man. Objectives of the present study were: (1) the development of a physiology-based model of the human BA metabolism, (2) population-based model validation and characterisation, and (3) the prediction and quantification of alter…