Search results for " modifica"

The role of elongational flow in morphology modification of Polyethylene/OMMT nanocomposite system

2011

The Epigenetics of the Endocannabinoid System

2020

The endocannabinoid system (ES) is a cell-signalling system widely distributed in biological tissues that includes endogenous ligands, receptors, and biosynthetic and hydrolysing machineries. The impairment of the ES has been associated to several pathological conditions like behavioural, neurological, or metabolic disorders and infertility, suggesting that the modulation of this system may be critical for the maintenance of health status and disease treatment. Lifestyle and environmental factors can exert long-term effects on gene expression without any change in the nucleotide sequence of DNA, affecting health maintenance and influencing both disease load and resistance. This potentially …

Carbohydrate-Based Nanocarriers Exhibiting Specific Cell Targeting with Minimum Influence from the Protein Corona.

2015

Whenever nanoparticles encounter biological fluids like blood, proteins adsorb on their surface and form a so-called protein corona. Although its importance is widely accepted, information on the influence of surface functionalization of nanocarriers on the protein corona is still sparse, especially concerning how the functionalization of PEGylated nanocarriers with targeting agents will affect protein corona formation and how the protein corona may in turn influence the targeting effect. Herein, hydroxyethyl starch nanocarriers (HES-NCs) were prepared, PEGylated, and modified on the outer PEG layer with mannose to target dendritic cells (DCs). Their interaction with human plasma was then s…

Characterization of the epigenetic modifications in human uterine leiomyomas and evaluation of their potential as therapeutic targets in vitro

2023

Los miomas o fibromas uterinos (UL) son los tumores benignos más frecuentes en las mujeres en edad reproductiva. A pesar de su elevada prevalencia y de las diferentes opciones de tratamiento, no existe terapia eficaz para la reducción del tamaño de los UL que sea mínimamente invasiva y sin efectos secundarios a largo plazo. Su patología tumoral permanece desconocida, lo que dificulta el desarrollo de tratamientos seguros y eficaces. Por lo tanto, la identificación de los mecanismos moleculares implicados en la generación de UL podría permitir el desarrollo de tratamientos más eficaces. Las modificaciones epigenéticas están implicadas en el desarrollo de los tumores y pueden revertirse media…

Appunti sulla struttura dell'espromissione cumulativa

2014

Estimates for the Differences of Certain Positive Linear Operators

2020

The present paper deals with estimates for differences of certain positive linear operators defined on bounded or unbounded intervals. Our approach involves Baskakov type operators, the kth order Kantorovich modification of the Baskakov operators, the discrete operators associated with Baskakov operators, Meyer&ndash

Biomimetic strategy towards gelatin coatings on PET. Effect of protocol on coating stability and cell-interactive properties

2019

Gelatin-modified poly(ethylene terephthalate) (PET) surfaces have been previously realized via an intermediate dopamine coating procedure that resulted in surfaces with superior haemocompatibility compared to unfunctionalized PET. The present study addresses the biocompatibility assessment of these coated PET surfaces. In this context, the stability of the gelatin coating upon exposure to physiological conditions and its cell-interactive properties were investigated. The proposed gelatin–dopamine-PET surfaces showed an increased protein coating stability up to 24 days and promoted the attachment and spreading of both endothelial cells (ECs) and smooth muscle cells (SMCs). In parallel, physi…

Striving for mutual understanding : native English speakers' views on speech modifications in intercultural encounters

2016

”Foreigner talk” -nimistä ilmiötä on aikaisemmin tutkittu melko laajaltikin eri näkökulmien kautta. Suurin osa tutkimuksesta on tehty 1980-luvulla, jonka jälkeen termin käyttö näyttää hiljalleen vähentyneen. ”Foreigner talk” tarkoittaa muokattua kieltä, jonka tarkoitus on tehdä puheesta ymmärrettävämpää henkilölle, jonka kompetenssi kohdekielessä ei ole toisen puhujan kanssa syystä tai toisesta samalla tasolla: kyseessä voivat olla esimerkiksi kieltä äidinkielenään puhuva henkilö ja kieltä vieraana kielenä puhuva henkilö. Aivan viime aikoina ilmiö näyttää nouseen taas suosioon tutkimuskohteena etenkin osana työympäristöä, jossa kansainväliset kohtaamiset ovat monelle arkipäivää. Siitä huoli…

Cholesterol-Streptolysin O Interaction: An EM Study of Wild-Type and Mutant Streptolysin O

1998

We present transmission electron microscopical data from negatively stained specimens of cholesterol following interaction with the thiol-activated bacterial toxin streptolysin O (SLO) (wild-type and a number of cysteine substitution mutants), with and without chemical modification of the cysteine residues. Two experimental systems were used, one with an aqueous suspension of cholesterol microcrystals and the other with immobilized thin planar cholesterol crystals attached to a carbon film. In both systems the wild-type SLO and two cytolytically active mutants, Cys 530 --Ala (C530A) and Ser 101 --Cys (S101C), readily generated the characteristic SLO arc- and ring-like oligomers on the surfa…

On implications of modified gravity models of dark energy

2014

152 páginas. Tesis Doctoral del Departamento de Física Teórica de la Universidad de Valencia y del Instituto de Física Corpuscular (IFIC).