Search results for " modulation"
showing 10 items of 496 documents
Myotonic dystrophy: candidate small molecule therapeutics
2017
Myotonic dystrophy type 1 (DM1) is a rare multisystemic neuromuscular disorder caused by expansion of CTG trinucleotide repeats in the noncoding region of the DMPK gene. Mutant DMPK transcripts are toxic and alter gene expression at several levels. Chiefly, the secondary structure formed by CUGs has a strong propensity to capture and retain proteins, like those of the muscleblind-like (MBNL) family. Sequestered MBNL proteins cannot then fulfill their normal functions. Many therapeutic approaches have been explored to reverse these pathological consequences. Here, we review the myriad of small molecules that have been proposed for DM1, including examples obtained from computational rational …
Treatment with a CO-releasing molecule (CORM-3) reduces joint inflammation and erosion in murine collagen-induced arthritis.
2008
Contains fulltext : 70589.pdf (Publisher’s version ) (Closed access) OBJECTIVE: CO-releasing molecules (CO-RMs) are a novel class of anti-inflammatory agents. We have examined the possible therapeutic effects of CORM-3 in collagen-induced arthritis (CIA). METHODS: Arthritis was induced in DBA-1/J mice by type II collagen. Animals were treated with CORM-3 (5 and 10 mg/kg/day, intraperitoneally) or the inactive compound iCORM-3 (10 mg/kg/day, intraperitoneally) unable to release CO, from days 22 to 31. Production of anti-type II collagen antibodies, cytokines and cartilage olimeric matrix protein (COMP) was evaluated by enzyme-linked immunosorbent assay, and prostaglandin E(2) (PGE(2)) by rad…
Modification of a commercial atomic force microscopy for low-noise, high-resolution frequency-modulation imaging in liquid environment.
2011
A key issue for high-resolution frequency-modulation atomic force microscopy imaging in liquids is minimizing the frequency noise, which requires a detailed analysis of the corresponding noise contributions. In this paper, we present a detailed description for modifying a commercial atomic force microscope (Bruker MultiMode V with Nanoscope V controller), aiming at atomic-resolution frequency-modulation imaging in ambient and in liquid environment. Care was taken to maintain the AFMs original stability and ease of operation. The new system builds upon an optimized light source, a new photodiode and an entirely new amplifier. Moreover, we introduce a home-built liquid cell and sample holder …
Measurement of nonlinear and chromatic dispersion parameters of optical fibers using modulation instability
2006
International audience; We present a simple method for the measurement of Kerr, second- and third-order dispersion coefficients in optical fibers using power and dispersion dependences of modulation instability near the zero-dispersion wavelength. We also complete the analysis by the accurate determination of the zero-dispersion wavelength of the fiber using the phase-matched four wave mixing process which occurs near this specific wavelength.
Polarisation attraction and incoherent modulation instability in optical fibers
2006
This thesis, entitled « Polarisation attraction and incoherent modulation instability in optical fibers », presents a theoretical and experimental study of two new processes from the nonlinear optic in optical fibers domain. We introduce in the first chapter some theoretical notions useful for the comprehension of this work. Then, we demonstrate in the second chapter that it is possible to generate some modulation instability in optical fibers using a partially coherent optical beam. We highlight and observe the main properties of the phenomenon. We study the polarisation attraction in isotropic fibers process in the third chapter. Our work proves the existence of the phenomenon, and permit…
Even harmonic pulse train generation by cross-polarization-modulation seeded instability in optical fibers
2012
International audience; We show that, by properly adjusting the relative state of polarization of the pump and of a weak modulation, with a frequency such that at least one of its even harmonics falls within the band of modulation instability, one obtains a fully modulated wave at the second or higher even harmonic of the initial modulation. An application of this principle to the generation of a 80-GHz optical pulse train with high extinction ratio from a 40-GHz weakly modulated pump is experimentally demonstrated using a nonzero dispersion shifted fiber in the telecom C band.
On the evaluation of an optical OFDM radio over FSO system with IM-DD for high-speed indoor communications
2017
En aquest article es proposa un nou sistema híbrid de ràdio sobre fibra (RoF) i òptica d’espai lliure (FSO) basat en la transmissió de senyals òptics OFDM (OOFDM) per proporcionar enllaços de comunicació sense fils òptics d’alta capacitat. Es proposa un esquema de transmissió de baix cost basat en IM-DD per simplificar i reutilitzar la infraestructura existent per desplegar un enllaç FSO d’alt ample de banda. Aquest article mostra els resultats experimentals basats en la implementació de l'esquema proposat sota una transmissió digital OOFDM de 16 QAM a través de 10 km de fibra monomode (SMF) i enllaç FSO de 300 mm. Els resultats mostren la viabilitat de desplegar un sistema de comunicació d…
On the effects of suitably designed space microstructures in the propagation of waves in time modulated composites
2023
In the one-dimensional case, the amplitude of a pulse that propagates in a homogeneous material whose properties are instantaneously changed in time will undergo an exponential increase due to the interference between the reflected and transmitted pulses generated at each sudden switch. Here, we resolve the issue by designing suitable reciprocal PT-symmetric space-time microstructures so that the interference between the scattered waves is such that the overall amplitude of the wave will be constant in time in each constituent material. Remarkably, for the geometries proposed here, a pulse will propagate with constant amplitude regardless of the impedance between the constituent materials,…
Dog-Owner Relationship, Owner Interpretations and Dog Personality Are Connected with the Emotional Reactivity of Dogs
2022
Simple Summary The relationship between owner and the dog affects the dog's attachment behaviors and stress coping. In turn, the quality of the relationship may affect owner's interpretations about their dog's behavior. Here, we assessed dogs' emotional responses from heart rate variability and behavioral changes during five different situations. Dog owners evaluated the emotion (valence and arousal) of their dog after each situation. We found that both negative and positive incidents provoked signs of emotional arousal in dogs. Owners detected the dog's arousal especially during fear- and stress-evoking situations. The dog-owner relationship did not affect owners' interpretation of dogs' e…
Post-exercise heart rate variability : a new approach to evaluation of exercise-induced physiological training load
2015
To improve maximal endurance performance, an optimal physiological training load, i.e. the balance between exercise and recovery, is required. In general, the goal of a single endurance exercise session is to transiently disturb body homeostasis after which a so-called supercompensation, an improvement in performance, can occur if the recovery period is adequate. The physical training load of a single exercise session consists of the combination of exercise intensity and duration. At the present time, there is no single tool to quantify the amount of disturbance of homeostasis that is equal to physiological training load of a single exercise session. Heart rate variability (HRV), the change…