Search results for " national"

showing 10 items of 469 documents

Polyoxypregnanes as safe, potent, and specific ABCB1-inhibitory pro-drugs to overcome multidrug resistance in cancer chemotherapy in vitro and in vivo

2021

Multidrug resistance (MDR) mediated by ATP binding cassette subfamily B member 1 (ABCB1) is significantly hindering effective cancer chemotherapy. However, currently, no ABCB1-inhibitory drugs have been approved to treat MDR cancer clinically, mainly due to the inhibitor specificity, toxicity, and drug interactions. Here, we reported that three polyoxypregnanes (POPs) as the most abundant constituents of Marsdenia tenacissima (M. tenacissima) were novel ABCB1-modulatory pro-drugs, which underwent intestinal microbiota-mediated biotransformation in vivo to generate active metabolites. The metabolites at non-toxic concentrations restored chemosensitivity in ABCB1-overexpressing cancer cells v…

ABCC1 ATP binding cassette subfamily C member 1IC50 half maximal inhibitory concentrationMultidrug resistancePharmacologyNADPH reduced nicotinamide adenine dinucleotide phosphateF bioavailabilitychemistry.chemical_compoundPCR polymerase chain reaction0302 clinical medicineMDR multidrug resistanceECL electrochemiluminescencet1/2 elimination half-lifeLC–MS liquid chromatography coupled with mass spectrometryN.D. not detectedGeneral Pharmacology Toxicology and PharmaceuticsBBB blood–brain barriermedia_commonATF3 activating transcription factor 30303 health sciencesChemistryABC ATP-binding cassetteNMPA National Medical Products AdministrationPXR pregnane X receptorSDS-PAGE sodium dodecyl sulfate-polyacrylamide gel electrophoresisHBSS Hankʹs balanced salt solutionABCB1Combination chemotherapyProdrugMarsdenia tenacissimaCmax peak concentrationPaclitaxelGAPDH glyceraldehyde-3-phosphate dehydrogenase030220 oncology & carcinogenesisBHI brain heart infusionOriginal ArticleAUC0–∞ area under plasma concentration vs. time curveMRT mean residence timeDrugmedia_common.quotation_subjectRM1-950Vd volume of distributionABCB1 ATP binding cassette subfamily B member 1UIC-2 mouse monoclonal ABCB1 antibodyABCG2 ATP binding cassette subfamily G member 2Combination chemotherapyCYP cytochrome P450 isozymePI propidium iodideTEER transepithelial electrical resistance03 medical and health sciencesPBS phosphate buffer salineFBS fetal bovine serumDox doxorubicinIn vivoPOP polyoxypregnanemedicine030304 developmental biologyEVOM epithelial tissue voltohmmeterTmax time for peak concentrationCancerLBE lowest binding energyPE phycoerythrinmedicine.diseaseMultiple drug resistancePolyoxypregnanePapp apparent permeabilityN.A. not applicableCancer cellH&E hematoxylin and eosinMDR1a multidrug resistance protein 1aTherapeutics. PharmacologyqPCR quantitative PCRM. tenacissima Marsdenia tenacissimaCL clearanceSD standard derivationActa Pharmaceutica Sinica B
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Metabolic signatures across the full spectrum of non-alcoholic fatty liver disease.

2022

Funder: European Commission

ALTtype 2 diabetes mellitusROC receiving operator characteristicaspartate aminotransferaseHSDLDL low-density lipoproteinUHPLC ultrahigh-performance liquid chromatographyROCHCCNon-alcoholic steatohepatitisGCPCANASHGastroenterology2-HB 2-hydroxybutanoic acid; 3-HB 3-hydroxybutanoic acid; ALT alanine aminotransferase; AST aspartate aminotransferase; CE cholesterol ester; Cer ceramide; FFA free fatty acid; FLIP Fatty Liver Inhibition of Progression; Fibrosis; GC gas chromatography; HCC hepatocellular carcinoma; HSD honest significant difference; LC lipid cluster; LDL low-density lipoprotein; LM lipid and metabolite; LMC lipid metabolite and clinical variable; LPC lysophosphatidylcholine; Lipidomics; Mass spectrometry; Metabolomics; NAFL non-alcoholic fatty liver; NAFLD non-alcoholic fatty liver disease; NAS NASH activity score; NASH non-alcoholic steatohepatitis; NIDDK NASH-CRN National Institute of Digestive Diseases and Kidney NASH Clinical Research Network; NRR non-rejection rate; Non-alcoholic steatohepatitis; PC(O) ether PC; PC phosphatidylcholine; PCA principal component analysis; PE phosphatidylethanolamine; QTOFMS quadrupole-time-of-flight mass spectrometry; ROC receiving operator characteristic; SAF steatosis activity and fibrosis; SM sphingomyelin; T2DM type 2 diabetes mellitus; TG triacylglycerol; UHPLC ultrahigh-performance liquid chromatographySAFSAF steatosis activity and fibrosisLM lipid and metabolitehonest significant differenceHSD honest significant differenceTG triacylglycerolnon-rejection ratecholesterol esterPCPEGC gas chromatographyfree fatty acidFLIPNASH non-alcoholic steatohepatitisNIDDK NASH-CRN National Institute of Digestive Diseases and Kidney NASH Clinical Research NetworkBIOMARKERST2DMPE phosphatidylethanolamineLDLlipidNAFLDFFA free fatty acid2-HBMetabolomicsNAFL non-alcoholic fatty liverLMCphosphatidylcholineScience & TechnologySM sphingomyelinGastroenterology & HepatologyMass spectrometryactivitynutritional and metabolic diseasesT2DM type 2 diabetes mellitusACIDSreceiving operator characteristicdigestive system diseasesquadrupole-time-of-flight mass spectrometryLC lipid clusterlow-density lipoproteinNAS2-HB 2-hydroxybutanoic acidNAS NASH activity scoreQTOFMSether PCNRRSCORING SYSTEMprincipal component analysisgas chromatographyLC2-hydroxybutanoic acidPROGRESSIONAST aspartate aminotransferaseLMPC phosphatidylcholinePC(O)MARKERSUHPLCsteatosisTOOLImmunology and AllergyINSULIN-RESISTANCECerSMFatty Liver Inhibition of Progressionhepatocellular carcinoma2-HB 2-hydroxybutanoic acid NIDDK NASH-CRN National Institute of Digestive Diseases and Kidney NASH Clinical Research Network NRR non-rejection rate Non-alcoholic steatohepatitis PC(O) ether PC PC phosphatidylcholine PCA principal component analysis PE phosphatidylethanolamine QTOFMS quadrupole-time-of-flight mass spectrometry ROC receiving operator characteristic SAF steatosis activity and fibrosis SM T2DM type 2 diabetes mellitus TG triacylglycerol UHPLC ultrahigh-performance liquid chromatographyultrahigh-performance liquid chromatographyCELPC3-HBNAFLnon-alcoholic fatty liverTGtriacylglycerolNRR non-rejection rateLife Sciences & BiomedicineNAFLD non-alcoholic fatty liver diseaseFLIP Fatty Liver Inhibition of Progressionalanine aminotransferasemetaboliteCer ceramideCE cholesterol estersphingomyelinlysophosphatidylcholineand fibrosisALT alanine aminotransferaseInternal MedicineceramideNational Institute of Digestive Diseases and Kidney NASH Clinical Research NetworkAST3-HB 3-hydroxybutanoic acidQTOFMS quadrupole-time-of-flight mass spectrometryPCA principal component analysisLPC lysophosphatidylcholineHepatologynon-alcoholic fatty liver diseaseand clinical variablePC(O) ether PC3-hydroxybutanoic acidFibrosisNASH activity scoreNIDDK NASH-CRNlipid clusterlipid and metabolitephosphatidylethanolamineLipidomicsLMC lipid metabolite and clinical variableFFAHCC hepatocellular carcinomaJHEP reports : innovation in hepatology
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Le valenze della Danza Movimento Terapia in presenza e a distanza. Corpo e relazioni durante la pandemia del COVID-19

2022

Elena Mignosi e Fernando Battista approfondiscono nella loro articolo le specificità della Danza Movimento Terapia (DMT) e i suoi numerosi ambiti applicativi (educativo, formativo clinico, terapeutico, sociale/inclusivo , riabilitativo). Conducono quindi una riflessione sulle modalità in presenza e da remoto, individuando quale efficacia possa avere partecipare ad un esperienza artisctico-creativa e corporea attraverso uno schermo. La pandemia da Covid 19 ha infatti reso necessario ripensare quelli che erano ritenuti i punti cardine del setting di DMT e di individuare nuove forme di interazione. Infine essi presentano brevemente i capitoli della rivista che costituiscono gli Atti del Conveg…

APID National Conference 2021DMT application areaIn-person and distance settingDanza Movimento TerapiaConvegno Nazionale APID 2021Dance Movement TherapySetting in presenza e a distanzaCovid Pandemic 19Settore M-PED/01 - Pedagogia Generale E SocialeAmbiti applicativi DMTPandemia Covid 19
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Misiņa bibliotēkas digitālās kolekcijas

2018

Academic Library of the University of Latviakolekciju digitalizācijaLatvian National Digital LibraryMisiņš Librarydigitization of collectionLatvijas Nacionālā digitālā bibliotēka:SOCIAL SCIENCES [Research Subject Categories]Latvijas Universitātes Akadēmiskā bibliotēkaMisiņa bibliotēka
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Gender differences in child and adolescent daily activities : a cross-national time use study

2021

This study used 2009–2015 time-diary data to examine gender differences in daily activities among children and adolescents aged 10–17 in Finland, Spain and the UK ( N = 3517). In all three countries, boys were significantly more involved in screen-based activities and exercising and girls in domestic work, non-screen educational activities and personal care. Gender differences in socializing time were only significant in the UK, with girls socializing more than boys. Gender gaps within countries were largest in domestic work (UK: 60%; Finland: 58%; Spain: 48%) and exercising (UK: 57%; Finland: 36%; Spain: 27%), followed by educational time (UK: 35%; Finland: 34%; Spain: 18%) and screen-bas…

Activities of daily livingCross-nationalDaily activitiesSociology and Political Sciencesukupuolierot05 social scienceslapset (ikäryhmät)kansainvälinen vertailu0506 political scienceChild and adolescentnuoretsukupuoliroolitajankäyttö050902 family studies050602 political science & public administrationGender differences0509 other social sciencesPsychologyTime useChildrenCross nationalDemography
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The Reform of the Rappresentativa: Roots and Routes of a National Art

2015

Curated Panel: Italian Acting I explore the remarkable role that the reform of the old Rappresentativa played in the years of Risorgimento, and examine the differences of application of the declamatory symbols in the old Rappresentativa and in the New Style that is referred as la romantica, or Drammatica, analysing Gustavo Modena, Adelaide Ristori and Gaetano Gattinelli’s prompt books and works. Gustavo Modena reformed the old style of the Rappresentativa and was an unforgettable patriot of Risorgimento as well as Ristori and Gattinelli. I explain how Modena steered the drammatica along a new course in the first fifty years of the nineteenth century and shaped the method giving it the goal …

Actors National Art declamationSettore L-ART/05 - Discipline Dello Spettacolo
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The effect of age on cognitive performance of frontal patients

2015

Age is known to affect prefrontal brain structure and executive functioning in healthy older adults, patients with neurodegenerative conditions and TBI. Yet, no studies appear to have systematically investigated the effect of age on cognitive performance in patients with focal lesions. We investigated the effect of age on the cognitive performance of a large sample of tumour and stroke patients with focal unilateral, frontal (n=68), or non-frontal lesions (n=45) and healthy controls (n=52). We retrospectively reviewed their cross sectional cognitive and imaging data. In our frontal patients, age significantly predicted the magnitude of their impairment on two executive tests (Raven's Advanc…

AdultMaleAgingRAPM Raven's Advanced Progressive MatricesCognitive NeuroscienceExperimental and Cognitive Psychologybehavioral disciplines and activitiesArticleTBI traumatic brain injuryCVA cerebrovascular accidentExecutive functionsBehavioral NeuroscienceExecutive FunctionPFC prefrontal cortexCognitionArts and Humanities (miscellaneous)WMA white matter abnormalitiesIL Incomplete Letters andAging; Cognitive performance; Executive functions; Frontal lesions non-frontal lesions; Behavioral Neuroscience; Cognitive Neuroscience; Experimental and Cognitive Psychology; Arts and Humanities (miscellaneous)Frontal lesions non-frontal lesionnon-frontal lesionsHumansHC healthy controlsCognitive performanceRetrospective StudiesCWMA Composite White Matter AbnormalitiesFrontal lesionsBrain NeoplasmsGNT Graded Naming TestAge FactorsBrainMiddle AgedFrontal LobeStrokeFrontal lesions non-frontal lesionsIQ Intelligence QuotientStroop TestFemaleNART National Adult Reading TestNeuropsychologia
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Health literacy in familial hypercholesterolemia: A cross-national study.

2018

Background High rates of inadequate health literacy are associated with maladaptive health outcomes in chronic disease including increased mortality and morbidity rates, poor treatment adherence and poor health. Adequate health literacy may be an important factor in the effective treatment and management of familial hypercholesterolemia, and may also be implicated in genetic screening for familial hypercholesterolemia among index cases. The present study examined the prevalence and predictors of health literacy in familial hypercholesterolemia patients attending clinics in seven countries. Design Cross-sectional survey. Methods Consecutive FH patients attending clinics in Australia, Brazil,…

AdultMaleHealth Knowledge Attitudes PracticeAsiaEpidemiologyHealth literacyFamilial hypercholesterolemia030204 cardiovascular system & hematologyHyperlipoproteinemia Type II03 medical and health sciences0302 clinical medicineAsian PeopleEnvironmental healthSurveys and QuestionnairesInternal MedicineMedicineEffective treatmentHumans030212 general & internal medicineta315health disparitiesAgedfamilial hypercholesterolemiabusiness.industrydyslipidemiaAge FactorsAustraliata3141General Medicinegenetic screeningMiddle Agedmedicine.diseaseHealth equityUnited KingdomHealth LiteracyChronic diseaseCross-Sectional StudiesIncomeHousehold incomeFemaleMETABOLISMObusinessCardiology and Cardiovascular Medicinehealth literacyDyslipidemiaCross nationalEuropean journal of preventive cardiology
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Factors Associated with Providers' Work Engagement and Burnout in Homeless Services: A Cross-national Study

2021

Contains fulltext : 232434.pdf (Publisher’s version ) (Closed access) The complexity of homeless service users' characteristics and the contextual challenges faced by services can make the experience of working with people in homelessness stressful and can put providers' well-being at risk. In the current study, we investigated the association between service characteristics (i.e., the availability of training and supervision and the capability-fostering approach) and social service providers' work engagement and burnout. The study involved 497 social service providers working in homeless services in eight different European countries (62% women; mean age = 40.73, SD = 10.45) and was part o…

AdultMaleSocial WorkHealth (social science)Applied psychologySupervisionBurnoutHealthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18]03 medical and health sciencesNegatively associatedProfessionalBurnoutTrainingHumans0501 psychology and cognitive sciencesService userBurnout ProfessionalApplied PsychologyService (business)030505 public healthServiceSocial workWork engagement05 social sciencesMultilevel model1. No povertyPublic Health Environmental and Occupational HealthHomelessnessHomeless PersonsBurnout; Capabilities; Homelessness; Service; Supervision; Training; Adult; Female; Humans; Male; Social Work; Work Engagement; Burnout Professional; Homeless PersonsWork EngagementCapabilitiesIll-Housed PersonsFemale0305 other medical sciencePsychology050104 developmental & child psychologyCross national
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Cross-national and longitudinal investigation of a short measure of workaholism

2015

The present study investigated the factor structure of the 10-item version of the Dutch Work Addiction Scale (DUWAS). The DUWAS-10 is intended to measure workaholism with two correlated factors: working excessively (WE) and working compulsively (WC). The factor structure of the DUWAS-10 was examined among multi-occupational samples from the Netherlands (n=9,010) and Finland (n=4,567) using confirmatory factor analysis (CFA). CFAs revealed that the expected correlated two-factor solution showed satisfactory fit to the data. However, a second-order factor solution, where WE comprised the first-order factors “working frantically” and “working long hours”, and WC the first-order factors “obsess…

AdultMaleWorkLongitudinal studyFactorialAdolescentPsychometricsPsychometricsHealth Toxicology and MutagenesisConfirmatory factor analysisYoung AdultStatisticsHumansToxicology and MutagenesisLongitudinal StudiesFactorial validityFinlandAgedNetherlandsDrivePsychiatric Status Rating ScalesMeasure (data warehouse)Cross-nationalWorkaholismEnvironmental and Occupational HealthPublic Health Environmental and Occupational HealthReproducibility of ResultsMiddle AgedConfirmatory factor analysisBehavior AddictiveHealthScale (social sciences)Compulsive BehaviorOriginal ArticleFemalePublic HealthIndustrial and organizational psychologyLongitudinal studyFactor Analysis StatisticalPsychologyCross national
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