Search results for " natural product"

USE OF NATURAL PRODUCTS FOR THE CONTROL OF POWDERY MILDEW OF ROSE PLANTS

2007

PowDery mildew caused by Podosphaera pannosa (Wallr. Fr.) De Bary on roses in greenhouse cultivation is usually controlled by chemical products. Aiming to lower the use of chemical treatments, in vitro and in planta assays were carried out using some natural products. The inhibitory effect of essential oils extracted from oregano inflorescences (Origanum heracleoticum L.) and cloves (Syzygium aromaticum L. Merril et L.M. Perry), was evaluated by in vitro tests. Essential oil at 0.5, and 0.125 ml/L concentration was added to conidia suspension (8 x 105 conidia/ml). After 2, 4, 8, 12, 24 and 48 hours, 400 conidia for each treatment and control were evaluated and the germination percentage cal…

Natural products against the powdery mildew of rose plants

2005

Control of powdery mildew in cut roses using natural products in the greenhouse.

2009

Roses grown under greenhouse cultivation are commonly affected by diseases and regular fungicide applications are commonly used. The aim of this research was to identify natural products that can substitute and reduce the health and environmental impacts of typical chemical treatments in the control of powdery mildew [(Podosphaera pannosa (Wallr. Fr.) de Bary] and grey mould (Botrytis cinerea Pers.). Treatments were applied in the greenhouse on the cut rose cultivars Sunluck (Gold Strike®) and Nirpbredy (New Fashion®) growing in a soilless system. Oregano and clove essential oil at 0.5 ml/l (an emulsifier was added) and sodium bicarbonate (NaHCO3) at 4 g/l were sprayed on rose plants to run…

Discovery of plants and fungi with antibacterial activity against Propionibacterium acnes

2016

Acne vulgaris is a common skin disorder that affects >85% of teenagers. Propionibacterium acnes is implicated in its pathogenesis, and like many other bacteria, is subject to emerging trends in antibiotic resistance. Novel therapies are in high demand. The aim of this study was to identify new leads for future pre-clinical development from herbal skin remedies used in Italy. We screened a unique natural product library composed of extracts from medicinal and randomly collected plants and fungi from the Mediterranean for growth-inhibitory and anti-biofilm activity in P. acnes. Evaluation of 157 extracts from 10 fungi and 58 plants led to the identification of crude extracts from seven specie…

Effetti antiproliferativi degli estratti di emociti dell'ascidia Styela plicata ( Tunicata)

2009

A compound-based proteomic approach discloses 15-ketoatractyligenin methyl ester as a new PPARγ partial agonist with anti-proliferative ability

2017

AbstractProteomics based approaches are emerging as useful tools to identify the targets of bioactive compounds and elucidate their molecular mechanisms of action. Here, we applied a chemical proteomic strategy to identify the peroxisome proliferator-activated receptor γ (PPARγ) as a molecular target of the pro-apoptotic agent 15-ketoatractyligenin methyl ester (compound 1). We demonstrated that compound 1 interacts with PPARγ, forms a covalent bond with the thiol group of C285 and occupies the sub-pocket between helix H3 and the β-sheet of the ligand-binding domain (LBD) of the receptor by Surface Plasmon Resonance (SPR), mass spectrometry-based studies and docking experiments. 1 displayed…

Novel inhibitors of mitochondrial respiratory chain: endoperoxides from the marine tunicate Stolonica socialis.

2001

The Mediterranean tunicate Stolonica socialis contains a new class of powerful cytotoxic acetogenins, generically named stolonoxides. In this paper, which also details the isolation and chemical characterization of a minor component (3a) of the tunicate extract, we report the potent inhibitory activity (IC(50) < 1 microM) of stolonoxides (1a and 3a) on mitochondrial electron transfer. The compounds affect specifically the functionality of complex II (succinate:ubiquinone oxidoreductase) and complex III (ubiquinol:cytochrome C oxidoreductase) in mammalian cells, thereby causing a rapid collapse of the whole energetic metabolism. This result, which differs from the properties of similar known…

Current Bioactive Azole-Containing Natural Products

2010

Cyclodextrins: heterocyclic molecules able to perform chiral recognition (Part II)

2006

The present paper collects the most significant advances appeared since late 1998 up to June 2005 in the field of applications of natural and modified cyclodextrins as chiral selectors, with particular regard for pharmaceuticals and natural products.

Anti-inflammatory activity in selected Antarctic benthic organisms

2014

Antarctic benthos was prospected in search for anti-inflammatory activity in polar benthic invertebrates, in two different geographical areas: deep-bottoms of the Eastern Weddell Sea and shallow-waters of the South Shetland Islands. A total of 36 benthic algae and invertebrate species were selected to perform solubility tests in order to obtain extracts that were soluble at an innocuous ethanol concentration (0.2%) for cell culture, and further test them for anti-inflammatory activity. From these, ethanol extracts of ten species from five different phyla resulted suitable to be studied in cell macrophage cultures (RAW 264.7). Cytotoxicity (MTT method) and production of inflammatory mediator…