Search results for " nef"

Dislipidēmija kā riska faktors nieru funkcionālo spēju samazinājumam I tipa cukura diabēta pacientiem

2019

Diabētiskā nefropātija ir svarīga un bieži diabēta pacienta dzīvību apdraudoša mikrovaskulāra komplikācija (Groop et al., 2009). Diabētiskās nefropātijas pacientiem dislipidēmiju sastop bieži, tomēr līdz šim veikto pētījumu rezultāti nav viennozīmīgi attiecībā uz seruma lipīdu frakciju ietekmi uz nieru funkciju. Pētījuma mērķis bija izpētīt 1. tipa cukura diabēta pacientu lipīdu un apolipoproteīnu līmeņu asociāciju ar nieru funkcionālo spēju (glomerulārā filtrācijas ātruma un albuminūrijas) samazinājumu laika gaitā. Veikts šķērsgriezuma tipa pētījums, kurā tika izmantoti 106 1. tipa cukura diabēta pacientu paraugi un klīniskie dati no „LatDiane: Latvijas diabētiskās nefropātijas pētījuma”, …

Community garden initiatives addressing health and well‐being outcomes: A systematic review of infodemiology aspects, outcomes, and target populations

2021

Previous research has suggested that activities such as community gardens could offer a wide range of health benefits. The aim of the article is to systematically review the available literature to analyse the magnitude of the phenomenon, the geographical distribution, and the main characteristics in terms of health outcomes and target populations. The search addresses the question whether the activity in community gardens improves health and well-being outcomes of individuals. From the total amount of 7226, 84 selected articles showed that:(1) up to 50% are published by U.S. universities or institutions; (2) up to 44% of the studies considered “community gardens” as the main activity of th…

Akadēmiskā Dzīve, 57

2021

Zinātņu vēsture un muzejniecība (Latvijas Universitātes Raksti, 809. sēj.)

2015

Oblicza autokracji w czeskich dystopiach literackich (na wybranych przykładach)

2018

The paper deals with the phenomenon of dystopia in Czech literaturę before 1989. The main aim of the article is to present some similiar views on totalitarian power and its influence on the individual in Czech novels and short stories: Datum narozeni nula by Ludmiła Freiova, Poselstvi pro Agla Mathona by Ondrej Neff, Utopie, nejlepśi verze by lvan Kminek and Maso by Martin Harmcek. The purpose of the paper was also to show how in the authors’ visions of autocratic States, administration is taking control over ordinary people and what kind of tools it uses to manipulate them: terror, self-censorship or various addictions.

Genome-wide Association Studies Identify Genetic Loci Associated with Albuminuria in Diabetes

2016

Elevated concentrations of albumin in the urine, albuminuria, are a hallmark of diabetic kidney disease and are associated with an increased risk for end-stage renal disease and cardiovascular events. To gain insight into the pathophysiological mechanisms underlying albuminuria, we conducted meta-analyses of genome-wide association studies and independent replication in up to 5,825 individuals of European ancestry with diabetes and up to 46,061 without diabetes, followed by functional studies. Known associations of variants in CUBN, encoding cubilin, with the urinary albumin-to-creatinine ratio (UACR) were confirmed in the overall sample (P = 2.4 × 10−10). Gene-by-diabetes interactions were…

Retinal and choroidal vasculature changes associated with chronic kidney disease

2018

Retinal and choroidal microvascular changes can be related to renal impairment in hypertension and chronic kidney disease (CKD). The study examines the association between retinochoroidal parameters and renal impairment in hypertensive, non-diabetic patients. This is a cross-sectional study on Caucasian patients with systemic arterial hypertension with different levels of renal function. All subjects were studied by blood chemistry, urine examination, microalbuminuria and blood pressure. Complete eye examination was completed with swept source optical coherence tomography (SS-OCT) and optical coherence tomography angiography (OCTA) scans of macular region. Patients were divided in groups: L…

Usefulness of microalbuminuria in cardiovascular risk stratification of essential hypertensive patients

2004

<i>Background/Aims:</i> To evaluate the influence of microalbuminuria (albumin excretion rate – AER) determination and echocardiography (ECHO) on cardiovascular risk stratification, initially performed according the 1999 WHO/ISH guidelines by using only routine diagnostic procedures with or without fundal examination. <i>Methods:</i> 312 essential hypertensives attending our institution were studied retrospectively. Cardiovascular risk was assessed in a semiquantitative way using four categories of absolute cardiovascular disease risk (low, medium, high and very high risk), as proposed by the 1999 WHO/ISH guidelines, on the basis of data on the average 10-year risk o…

ASSOCIATION OF RENAL RESISTIVE INDEX WITH MARKERS OF EXTRARENAL VASCULAR CHANGES IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS

2016

Introduction: Recent data suggest that renal hemodynamic parameters obtained by duplex Doppler sonography, especially the intrarenal resistive index (RRI), may be associated with systemic vascular changes. However, limited and conflicting data exist about the relationship between aortic stiffness and RI in autoimmune diseases, like systemic lupus erythematosus (SLE). Aim: To evaluate the relationship between RRI and arterial stiffness, assessed by aortic pulse wave velocity (aPWV), and between RRI and carotid atherosclerosis, evaluated by intima-media thickness (IMT) measurement in patients with SLE. Methods: In this cross-sectional study, we enrolled 39 SLE subjects (mean age 39 years) tha…

Association between uric acid and renal function in hypertensive patients: which role for systemic vascular involvement?

2016

The role of systemic vascular involvement in mediating the association between serum uric acid (SUA) and renal function in hypertension has not been explored. Main purpose of our study was to investigate whether morphofunctional vascular changes, assessed as carotid intima-media thickness (cIMT) and aortic pulse wave velocity (aPWV), might mediate the association between SUA and renal damage. We enrolled 523 hypertensive subjects with or without chronic kidney disease and divided population into tertiles of SUA based on sex-specific cutoff values. cIMT and aPWV were higher in uppermost SUA-tertile patients when compared to those in the lowest ones (all P < .001). Uricemia strongly correlate…