Search results for " nef"

Ruolo della Ciclofosfamide nel trattamento del Lupus Eritematoso Sistemico in paziente afroamericana con severo incremento degli indici di funzionali…

2022

Introduzione: la Ciclofosfamide rappresenta con il Micofenolato Mofetile uno tra i farmaci di scelta nelle fasi di induzione della nefrite lupica. Tuttavia, risulta ancora controverso il suo utilizzo nei soggetti di razza afroamericana. Caso Clinico: Paziente afroamericana puerpera di 36 anni, che giungeva alla nostra osservazione dopo parto cesareo in urgenza alla 34° settimana per riscontro di preclampasia. La paziente si presentava in stato anasarcatico, oligoanurica, con severa alterazione degli indici di funzione renale (Cr 4 mg/dl) proteinuria in range nefrosico ed anemizzazione severa. Storia di TBC linfonodale. Riscontro di positività ad esami bioumorali di autoimmunità: ANA, Anti- …

[OP.3B.03] INFLUENCE OF SUBCLINICAL RENAL DAMAGE ON EARLY VASCULAR AGING IN PATIENT WITH SYSTEMIC LUPUS ERYTHEMATOSUS

2016

Objective: It is well known that kidney is frequently involved in patients with Systemic Lupus Erythematosus (SLE) However, conflicting data exist about the impact of renal involvement on vascular damage in this group of patients. The aim of this study was to evaluate the influence of renal damage on assessed by aortic pulse wave velocity (aPWV), evaluated a by intima-media thickness (IMT) measurement and assessed by renal resistive index (RRI) measurement, in patients with SLE. Design and method: We enrolled 52 SLE subjects (mean age 39 +/- 12 years), divided in two subgroups according to ACR/SLICC classification: patients with lupus nephritis, (LNG), and individuals presenting other featu…

SUBCLINICAL RENAL DAMAGE IS ASSOCIATED WITH A REDUCED CHOROIDAL THICKNESS IN PATIENTS WITH PRIMARY HYPERTENSION

2018

Objective: The retina is considered the easiest accessible window to study the state of the systemic microcirculation, even if the choroid is the most important vascular layer of the eye. Our understanding of the choroid has been greatly increased in last years since the introduction of advanced techniques of optical coherence tomography (OCT). Our study was aimed to assess choroidal thickness by using Swept-Source OCT (SS-OCT) in essential hypertensive patients (EHs) with and without subclinical renal damage (SRD). Design and method: We enrolled 100 EHs of which 65 without kidney damage and 35 with SRD. In all the participants SS-OCT and a routine biochemical work-up were performed. Glomer…

VALUTAZIONE DELLE RELAZIONI DELLO STRESS OSSIDATIVO, DELLA DISFUNZIONE ENDOTELIALE E DELLA FLOGOSI CON LE ALTERAZIONI MORFOFUNZIONALI CARDIOVASCOLARI…

2012

Infrared Spectroscopy In Urolithiasis In Children

2014

Aspetti psicologici in dialisi e nei pazienti non collaboranti

2005

L’emodialisi e la dialisi peritoneale, anche se rappresentano (con il trapianto) la terapia sostitutiva d’elezione dell’insufficienza renale, non sempre vengono vissute positivamente dai pazienti, a causa delle rigide prescrizioni terapeutiche e per i cambiamenti che apportano nella vita quotidiana (1,2). Ciò potrebbe incidere negativamente sulla non compliance che è definita, in entrambi i trattamenti, come l’inosservanza parziale o totale della terapia, che può essere associata alla non accettazione del trattamento sostitutivo (3). In letteratura viene stimato che il 50% dei pazienti in emodialisi ed un terzo di quelli in peritoneale abbia almeno una parziale non compliance che nella magg…

G.F.R. measuring with 99mTc-DTPA: limits in obstructive acute renal failure.

1991

After a short introduction on the advantages and limits of G.F.R. determination with Ccr, the radioisotopic methods proposed by Schlegel and Gates for this parameter are described, and as well as ERPF and FF, without blood serial samples being necessary. In a severe renal failure case due to obstruction, the Authors have found a great mismatch in the results between the traditional methods and the radioisotopic ones. After the clinical case description, a possible explanation of this discrepancy is proposed: Schlegel and Gates' methods, which well correlate Ccr in chronic renal failure cases, in severe renal failure on obstructive basis, of recent onset, could not indicate the effective glo…

PLASMA ENDOTHELIN-1 IS ASSOCIATED WITH AORTIC STIFFNESS IN ESSENTIAL HYPERTENSION

2011

Background: Experimental studies documented that endothelin-1 (ET-1) contributes to arterial stiffness and recently, in patients with chronic kidney diseases, it has been observed that selective endothelin-A receptor antagonism reduces arterial stiffness, in part independently of blood pressure lowering. Little is known about the relationships between ET-1 plasma levels and aortic distensibility in subjects with essential hypertension. Objective: The aim of our study was to analyse the relationships between plasma concentrations of ET-1 and carotid-femoral pulse wave velocity (c-f PWV), as an index of aortic stiffness, in a group of hypertensive patients without overt renal insufficiency [e…

Circulating levels of molecular adhesion correlate with stage of renal disease and C-reactive protein in chronic kidney disease

2007

BACKGROUND: Patients with chronic renal failure (CRF) suffer from a series of complications linked to the atherosclerotic process in which the endothelial dysfunction mediated by the activation of some adhesion molecules plays an important role. This study aims to evaluate circulating levels of intercellular adhesion molecules-1 (ICAM-1) and vascular cell adhesion molecules-1 (VCAM-1) in patients with predialysis CRF, on maintenance hemodialysis (HD) and after kidney transplantation (KTx) and to correlate them with some inflammation and nutritional indexes. METHODS: Thirty two patients with predialysis CRF, 30 on maintenance HD, 36 after KTx and 28 subjects as a control group (C) were inclu…

Oxidative stress, inflammation and cardiovascular disease in chronic renal failure

2008

Traditional risk factors such as hypertension, diabetes, dyslipidemia, obesity and metabolic syndrome, as well as additional nontraditional risk factors, can damage the kidney directly and by promoting intrarenal atherogenesis. Evidence indicates that increased oxidative stress and inflammation may mediate most of the effects of risk factors on the kidney. Clinical studies have demonstrated a relationship between oxidative stress and inflammatory biomarkers, and a few studies indicate an inverse correlation of oxidative stress biomarkers with estimated glomerular filtration rate (eGFR). Further, surrogate indexes of atherosclerosis such as intima-media thickness and aortic pulse wave veloci…