Search results for " neutral"
showing 10 items of 654 documents
The Monoclonal Antitoxin Antibodies (Actoxumab–Bezlotoxumab) Treatment Facilitates Normalization of the Gut Microbiota of Mice with Clostridium diffi…
2016
Antibiotics have significant and long-lasting impacts on the intestinal microbiota and consequently reduce colonization resistance against Clostridium difficile infection (CDI). Standard therapy using antibiotics is associated with a high rate of disease recurrence, highlighting the need for novel treatment strategies that target toxins, the major virulence factors, rather than the organism itself. Human monoclonal antibodies MK-3415A (actoxumab–bezlotoxumab) to C. difficile toxin A and toxin B, as an emerging non-antibiotic approach, significantly reduced the recurrence of CDI in animal models and human clinical trials. Although the main mechanism of protection is through direct neutraliza…
Development of a Sensitive Detection Method for Alphaviruses and Its Use as a Virus Neutralization Assay
2021
Alphaviruses have a single-stranded, positive-sense RNA genome that contains two open reading frames encoding either the non-structural or the structural genes. Upon infection, the genomic RNA is translated into the non-structural proteins (nsPs). NsPs are required for viral RNA replication and transcription driven from the subgenomic promoter (sgP). Transfection of an RNA encoding the luciferase gene under the control of the sgP into cells enabled the detection of replication-competent chikungunya virus (CHIKV) or Mayaro virus (MAYV) with high sensitivity as a function of the induced luciferase activity. This assay principle was additionally used to analyze virus-neutralizing antibodies in…
"Expected upper limit 3" of "Search for chargino-neutralino production using recursive jigsaw reconstruction in final states with two or three charge…
2018
Expected exclusion limits at 95% CL on the masses of C1/N2 and N1 from the analysis of 36.1fb$^{-1}$ of 13 TeV $pp$ collision data obtained from the statistical combination of the $2\ell$ and 3$\ell$ search channels, assuming 100\% branching ratio of the sparticles to decay to SM $W/Z$ bosons and LSP.
"Cross-section UL 3L" of "Search for chargino-neutralino production using recursive jigsaw reconstruction in final states with two or three charged l…
2018
Observed 95% CL upper limit on the production cross-section of C1/N2 from the analysis of 36.1fb$^{-1}$ of 13 TeV $pp$ collision data obtained from the 3$\ell$ search, assuming 100% branching ratio of the sparticles to decay to SM $W/Z$ bosons and N1.
"Observed upper limit 3" of "Search for chargino-neutralino production using recursive jigsaw reconstruction in final states with two or three charge…
2018
Observed exclusion limits at 95% CL on the masses of C1/N2 and N1 from the analysis of 36.1fb$^{-1}$ of 13 TeV $pp$ collision data obtained from the statistical combination of the $2\ell$ and 3$\ell$ search channels, assuming 100% branching ratio of the sparticles to decay to SM $W/Z$ bosons and LSP.
"Observed Upper limit 1" of "Search for chargino-neutralino production using recursive jigsaw reconstruction in final states with two or three charge…
2018
Observed exclusion limits at 95% CL on the masses of C1/N2 and N1 from the analysis of 36.1fb$^{-1}$ of 13 TeV $pp$ collision data obtained from the 2$\ell$ search, assuming 100% branching ratio of the sparticles to decay to SM $W/Z$ bosons and LSP.
"Expected upper limit 1" of "Search for chargino-neutralino production using recursive jigsaw reconstruction in final states with two or three charge…
2018
Expected exclusion limits at 95% CL on the masses of C1/N2 and N1 from the analysis of 36.1fb$^{-1}$ of 13 TeV $pp$ collision data obtained from the 2$\ell$ search, assuming 100\% branching ratio of the sparticles to decay to SM $W/Z$ bosons and LSP.
"Expected upper limit 2" of "Search for chargino-neutralino production using recursive jigsaw reconstruction in final states with two or three charge…
2018
Expected exclusion limits at 95% CL on the masses of C1/N2 and N1 from the analysis of 36.1fb$^{-1}$ of 13 TeV $pp$ collision data obtained from the the $3\ell$ search, assuming 100% branching ratio of the sparticles to decay to SM $W/Z$ bosons and LSP.
"Cross-section UL 2L" of "Search for chargino-neutralino production using recursive jigsaw reconstruction in final states with two or three charged l…
2018
Observed 95% CL upper limit on the production cross-section of C1/N2 from the analysis of 36.1fb$^{-1}$ of 13 TeV $pp$ collision data obtained from the 2$\ell$ search, assuming 100% branching ratio of the sparticles to decay to SM $W/Z$ bosons and N1.
"Observed upper limit 2" of "Search for chargino-neutralino production using recursive jigsaw reconstruction in final states with two or three charge…
2018
Observed exclusion limits at 95% CL on the masses of C1/N2 and N1 from the analysis of 36.1fb$^{-1}$ of 13 TeV $pp$ collision data obtained from the the $3\ell$ search, assuming 100% branching ratio of the sparticles to decay to SM $W/Z$ bosons and LSP.