Search results for " obesity"
showing 10 items of 504 documents
The Synbiotic Combination of Akkermansia muciniphila and Quercetin Ameliorates Early Obesity and NAFLD through Gut Microbiota Reshaping and Bile Acid…
2021
Gut microbiota plays a key role in obesity and non-alcoholic fatty liver disease (NAFLD), so synbiotics could be a therapeutic alternative. We aim to evaluate a nutritional intervention together with the administration of the bacteria Akkermansia muciniphila and the antioxidant quercetin in an in vivo model of early obesity and NAFLD. 21-day-old rats were fed with control or high-fat diet for six weeks. Then, all animals received control diet supplemented with/without quercetin and/or A. muciniphila for three weeks. Gut microbiota, NAFLD-related parameters, circulating bile acids (BAs) and liver gene expression were analyzed. The colonization with A. muciniphila was associated with less bod…
Influence of Geographical Area and Living Setting on Children's Weight Status, Motor Coordination, and Physical Activity
2022
This study was aimed (i) to examine the effect of living setting (rural vs. urban), geographical area (North vs. Center vs. South), and gender (boys vs. girls) on weight status, motor coordination, and physical activity (PA) level of Italian school-age children; (ii) to examine differences in the neighborhood walkability of different school areas from different geographical areas and living settings; and (iii) to examine whether motor coordination, PA level, geographical areas, living setting, neighborhood walkability, and gender could predict children's weight status. We assessed anthropometric parameters, gross motor coordination, and PA level in 1,549 children aged between 8 and 13 years…
Macrophage scavenger receptor 1 mediates lipid-induced inflammation in non-alcoholic fatty liver disease.
2022
Background & Aims: Obesity-associated inflammation is a key player in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). However, the role of macrophage scavenger receptor 1 (MSR1, CD204) remains incompletely understood. Methods: A total of 170 NAFLD liver biopsies were processed for transcriptomic analysis and correlated with clinicopathological features. Msr1(-/-) and wild-type mice were subjected to a 16-week high-fat and high-cholesterol diet. Mice and ex vivo human liver slices were treated with a monoclonal antibody against MSR1. Genetic susceptibility was assessed using genome-wide association study data from 1,483 patients with NAFLD and 430,101 participants of the U…
Obesity and HFpEF.
2022
Heart failure with preserved ejection fraction (HFpEF) has represented a therapeutic challenge in recent decades [...]
Brief interventions in counselling for nutrition and the prevalence of metabolic syndrome in primary care adult patients
2018
This research i) examined the influence of a brief nutrition-based intervention among primary care patients in changing nutrition and clinical values related to metabolic syndrome (study 1), and ii) assessed nutrition and the prevalence of metabolic syndrome and its clinical determinants among primary care patients in different sociodemographic groups (study 2). In study 1, a systematic literature review was conducted on eight databases during Sept.-Oct. 2016 with a final update in Nov. 2017. In study 2, data (n=557 for RO II-III, n=251 for RO IV-V) collected in primary care practices in Central Finland in 2006-2008 for the EVI study were analysed using Chi-Square test, GLM and Logistic Reg…
Leisure-time physical activity habits and abdominal adiposity in young adulthood : twin cohort and co-twin control studies
2018
Twin study designs were utilized to investigate how and what types of leisure- time physical activity (LTPA) are associated with abdominal adiposity in young adulthood taking into consideration diet and other selected health factors. The data of two studies were used: the longitudinal FinnTwin16 cohort and the clinical FITFATWIN study. In FinnTwin16, questionnaire data together with self- measured waist circumference (WC) of 3 383 (1 578 men) cohort members at mean ages 24.5 y and 34 y were used to study LTPA level and waist gain. Cross- sectional data of 4 027 (1 874 men) cohort members at mean age 34 y was used to study LTPA modes and WC. In FITFATTWIN study, ten monozygotic (MZ) male twi…
Perinatal Western Diet Consumption Leads to Profound Plasticity and GABAergic Phenotype Changes within Hypothalamus and Reward Pathway from Birth to …
2017
This article is part of the Research Topic Early Life Origins of Obesity and Type 2 Diabetes.; International audience; Perinatal maternal consumption of energy dense food increases the risk of obesity in children. This is associated with an overconsumption of palatable food that is consumed for its hedonic property. The underlying mechanism that links perinatal maternal diet and offspring preference for fat is still poorly understood. In this study, we aim at studying the influence of maternal high-fat/high-sugar diet feeding [western diet (WD)] during gestation and lactation on the reward pathways controlling feeding in the rat offspring from birth to sexual maturity. We performed a longit…
Entrenamiento en remediación cognitiva y habilidades emocionales en formato grupal para pacientes con obesidad: un estudio piloto
2017
Abstract: Group cognitive remediation and emotion skills training for patients with obesity. A pilot study. Cognitive remediation and emotion skills training was initially designed by the Tchanturia group for individual intervention in patients with eating disorders. The purpose of the present study is to present its adaptation to patients with obesity in group format. It is structured in 8 weekly sessions that work on central executive functions, the relation between emotion and thought, and emotion regulation in oneself and others. In addition, we present the preliminary results of its application to a group of 5 participants with morbid obesity to assess its possible efficacy. The result…
Childhood Obesity and Maternal Personality Traits: A New Point of View on Obesity Behavioural Aspects.
2021
The epidemic spread of childhood obesity in Western society has interested many researchers, who agree in defining it as a multifactorial disease in which not only eating habits and sedentary lifestyle play a role, but also genetic predisposition. The aim of this study was to analyze the personality profile of a group of mothers of children with obesity and to compare this profile to that of a group of mothers of children without obesity. A total of 258 mothers participated in the study (126 mothers of children with obesity and 132 mothers of children without obesity). Weight and height were measured and the body mass index was calculated. The Minnesota Multiphasic Personality Inventory sec…
The Role of Adipose Tissue and Adipokines in Obesity-Related Inflammatory Diseases
2010
Obesity is an energy-rich condition associated with overnutrition, which impairs systemic metabolic homeostasis and elicits stress. It also activates an inflammatory process in metabolically active sites, such as white adipose tissue, liver, and immune cells. As consequence, increased circulating levels of proinflammatory cytokines, hormone-like molecules, and other inflammatory markers are induced. This determines a chronic active inflammatory condition, associated with the development of the obesity-related inflammatory diseases. This paper describes the role of adipose tissue and the biological effects of many adipokines in these diseases.