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RESEARCH PRODUCT
The Role of Adipose Tissue and Adipokines in Obesity-Related Inflammatory Diseases
Giuseppina CandoreCarmela Rita BalistreriCalogero Carusosubject
medicine.medical_specialtyAgingImmunologyAdipose tissueAdipokineInflammationWhite adipose tissueReview ArticleProinflammatory cytokineOvernutritionImmune systemOvernutritionAdipokinesInternal medicinemedicinelcsh:PathologyHumansObesityInflammationSettore MED/04 - Patologia GeneraleChronic Activebusiness.industryobesity adipokines obesity related inflammatory diseasesCell Biologymedicine.diseaseEndocrinologyAdipose TissueImmunologymedicine.symptombusinesslcsh:RB1-214description
Obesity is an energy-rich condition associated with overnutrition, which impairs systemic metabolic homeostasis and elicits stress. It also activates an inflammatory process in metabolically active sites, such as white adipose tissue, liver, and immune cells. As consequence, increased circulating levels of proinflammatory cytokines, hormone-like molecules, and other inflammatory markers are induced. This determines a chronic active inflammatory condition, associated with the development of the obesity-related inflammatory diseases. This paper describes the role of adipose tissue and the biological effects of many adipokines in these diseases.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2010-07-01 |