Search results for " oncologia"
showing 10 items of 366 documents
USE OF HERBAL REMEDIES AMONG CANCER AND TRANSPLANT PATIENTS IN THE TOWN OF PALERMO, SICILY
2010
Concomitant use of herbal remedies may lead to toxicity or failure of conventional therapies in different patients. The objectives of this survey were to assess: (1) the prevalence of the use of vegetal remedies by cancer and transplanted patients (2) the level of communication about such use to the physicians (3) whether such use might be associated to adverse reactions or interactions with conventional drugs. The study was carried out on 100 consecutive cancer patients attending the outpatient medical oncology clinic of the University Hospital "P. Giaccone", Palermo and on other 100 transplanted patients who were hospitalized or followed up at ISMETT, Palermo. Another group was composed o…
Tumor markers in urogynaecological tumors.
2005
Quality of life, alexithymia, and defence mechanisms in patients affected by breast cancer across different stages of illness
2016
Objectives: The aim of this study was to evaluate the effect of alexithymia and defence mechanisms on the quality of life of patients affected by breast cancer at different stages of the disease. Methods A convenience sample of 110 patients with breast cancer was involved in the study: 41 were receiving adjuvant chemotherapyafter surgery, 29 had disease-free survival in follow-up and 40 were receiving chemotherapy for metastatic disease. Quality of life, alexithymia and defence mechanisms were assessed using the following instruments: EORTC QLQ-C30-BR23, Toronto Alexithymia Scale (TAS-20) and Defense Mechanism Inventory (DMI). Results Compared to the other groups, patients receiving chemoth…
Molecular analysis of TP53, Ki-Ras and P16 methylation status in tissue and plasma of subjects affected by gastrointestinal cancer (GIC)
2007
BACKGROUND: Despite the improvement in detection and surgical therapy in the last years, the outcome of patients affected by colorectal carcinoma (CRC) remains limited by metastatic relapse. The aim of this study was to investigate the presence of free tumor DNA in the plasma of CRC patients in order to understand its possible prognostic role. PATIENTS AND METHODS: Ki-Ras, TP53 mutations and p16(INK4A) methylation status were prospectively evaluated in tumor tissues and plasma of 66 CRC patients. RESULTS: In 50 of the 66 primitive tumor cases (76%) at least one significant alteration was identified in Ki-Ras and/or TP53 and/or p16(INK4A) genes. Eighteen of the 50 patients presented the same…
Analisi retrospettiva degli errori di posizione dei pazienti e l'impatto della dose nella colonscopia virtuale mediante TCMS: esperienza di un singol…
2016
La Colonscopia virtuale (CV) tramite tomografia computerizzato multi-strato (TCMS) è una nota e valida tecnica alternativa alla colonscopia ottica per la valutazione della parete del colon e la individuazione di nuove lesioni. Lo svantaggio principale per la sua esecuzione è l’esposizione del paziente alle radiazioni ionizzanti. Questo è il motivo per cui linee guida raccomandano procedure di acquisizione a basso dosaggio standardizzate volte a ridurre al minimo le radiazioni di esposizione. Abbiamo retrospettivamente esaminato l'impatto in termini di esposizione alle radiazioni ionizzanti in base alla posizione del paziente e la durata della scansione. [1].
EFFECTS OF CELLULAR SHORT-TERM STARVATION ON CONVENTIONAL CHEMOTHERAPY RESPONSE IN HUMAN CANCER: UNDERSTANDING OF MOLECULAR MECHANISMS AND MICRORNAS …
Background: Short Term Starvation (STS) is a type of dietary restriction able to reduce tumorigenesis and cancer progression but molecular bases of this effect are still unclear. Aim: In vitro analysis of STS effects in presence of chemotherapy and evaluation of microRNAs (miRNAs) involvement. Results: STS affects the expression profiles of miRNAs involved in chemotherapy response leading to cancer cells sensitization and to healthy cells protection.
BrafV600E mutation and hyperexpression of tissue inhibitor of metalloproteinases-1 (TIMP-1) in papillary thyroid carcinoma
2009
Tumor protein 53-induced nuclear protein 1 expression is repressed by miR-155, and its restoration inhibits pancreatic tumor development.
2007
Pancreatic cancer is a disease with an extremely poor prognosis. Tumor protein 53-induced nuclear protein 1 ( TP53INP1 ) is a proapoptotic stress-induced p53 target gene. In this article, we show by immunohistochemical analysis that TP53INP1 expression is dramatically reduced in pancreatic ductal adenocarcinoma (PDAC) and this decrease occurs early during pancreatic cancer development. TP53INP1 reexpression in the pancreatic cancer-derived cell line MiaPaCa2 strongly reduced its capacity to form s.c., i.p., and intrapancreatic tumors in nude mice. This anti-tumoral capacity is, at least in part, due to the induction of caspase 3-mediated apoptosis. In addition, TP53INP1 −/− mouse embryonic…
MICRORNA-21 EXPRESSION IN VESTIBULAR SCHWANNOMA: POTENTIAL EFFECT ON GROWTH AND POSSIBLE PROGNOSTIC FACTOR
2011
Background: Vestibular schwannomas are benign slow growing tumors arising from VIII cranial nerve. They are potential life threatening benign tumor because of intracranial located. The management could be surgical or conservative, but, left untreated, the tumor preserve the possibility to further growth and complication may arise. The natural history is however not predictable and prognostic factor to select patients manageable conservatively should be studied. The molecular pathways that lead to tumorigenesis and growth are not completely defined and a role could be played by microRNA. Elevated levels of microRNA-21 may contribute to tumor growth by deregulating the tumor suppressor phosph…
Indagine preliminare sulla presenza di composti ad attività antitumorale (lignani) in campioni di frumento duro siciliano e prodotti derivati.
2011
I Lignani costituiscono una particolare classe di composti fenolici caratterizzati da attività antiestrogenica e antitumorale. Sono contenuti principalmente nei semi di lino e di sesamo, nell’olio extra vergine di oliva, nei cereali a chicco intero, in varie verdure e frutta. In letteratura si ritrovano dati relativi al contenuto in lignani di vari cereali tra cui il grano tenero, ma quelli del grano duro sono frammentari o nulli. Per questo motivo abbiamo condotto uno studio preliminare per la determinazione del contenuto in lignani in campioni di grano duro, semole, pasta e pane prodotti in Sicilia raccolti nel corso del 2010. Dopo estrazione, i campioni sono stati sottoposti ad analisi i…