Search results for " ontology"
showing 10 items of 175 documents
Husserl’s Concept of “Intentionality” as the Starting Point for Sartre’s Thinking
1991
The influence of Phenomenology, especially that of Husserl, is extremely important in Sartre’s thinking, particularly in the first period which reaches its high point with the phenomenological ontology expounded in L’etre et le neant.
Analysis of the Molecular Dialogue Between Gray Mold (Botrytis cinerea) and Grapevine (Vitis vinifera) Reveals a Clear Shift in Defense Mechanisms Du…
2015
Mature grapevine berries at the harvesting stage (MB) are very susceptible to the gray mold fungus Botrytis cinerea, while veraison berries (VB) are not. We conducted simultaneous microscopic and transcriptomic analyses of the pathogen and the host to investigate the infection process developed by B. cinerea on MB versus VB, and the plant defense mechanisms deployed to stop the fungus spreading. On the pathogen side, our genome-wide transcriptomic data revealed that B. cinerea genes upregulated during infection of MB are enriched in functional categories related to necrotrophy, such as degradation of the plant cell wall, proteolysis, membrane transport, reactive oxygen species (ROS) genera…
Fisica platonica e teoria dell'immagine
2013
Starting out from the distinction between a "proper" notion of Being and a metphorical one in Plato, this paper aims at investigating the connection between Plato's ontology (as developed in dialogues as "Parmenides", "Sophist" and "Philebus") and his Physics (as described in the "Timaeus"). The author recognizes as central points of this connection the role of the causative model in both the creation (by God) and perception (by man) of the phyiscal world and the notion of "image" as the key to interpretate the bond between physical and meta-physical space in Plato.
Exploring the concept of causal power in a critical realist tradition
2007
This article analyses and evaluates the uses of the concept of causal power in the critical realist tradition, which is based on Roy Bhaskar's philosophy of science. The concept of causal power that appears in the early works of Rom Harre and his associates is compared to Bhaskar's account of this concept and its uses in the critical realist social ontology. It is argued that the concept of emergence should be incorporated to any adequate notion of causal power. The concept of emergence used in Bhaskar and other critical realists' works is shown to be ambiguous. It is also pointed out that the concept of causal power should be analysed in an anti-essentialist way. Ontological and methodolog…
Individuals, Identity, Names: Phenomenological Considerations
1997
In Husserl’s early writings (the Logical Investigations and the first section of Ideas I) the main concern of phenomenological investigations is the givenness of the ideal entities of logic and formal ontology. Another field in his earlier writings is the phenomenology of perception and time consciousness. This field of research broadens into the vision of a universal transcendental aesthetics, which, in his later writings, provides the basis for solving the problem of intersubjectivity.1 The final “synthesis” of these fields and problem domains is to be found in the phenomenological theory of the life-world. Lectures and research manuscripts2 of the late period show also that this second f…
PRIMO LEVI E LA QUESTIONE DELL’ANIMALITÀ
2020
The approach of man and animal in Levi’s work can lead to some simplifications. We could think of a naturalization operation: man is one of many animals. Or, on the contrary, we could think of a culturalization: the animal is a social being. In reality, the ontological principle on which Levi’s thinking and writing are based is that of analogy. Assuming the hypothesis of the anthropologist Philippe Descola, this essay proposes an analogical reading of Levi. Focusing on a precise story, Censura in Bitinia, I will try to discuss this interpretative hypothesis.
Comparative Quantitative Analysis of Porcine Optic Nerve Head and Retina Subproteomes
2019
Optic nerve head (ONH) and retina (RET) are the main sites of damage in neurodegenerative optic neuropathies including glaucoma. Up to date, little is known about the molecular interplay between these two adjoining ocular components in terms of proteomics. To close this gap, we investigated ONH and RET protein extracts derived from porcine eyes (n = 12) (Sus scrofa domestica Linnaeus 1758) using semi-quantitative mass spectrometry (MS)-based proteomics comprising bottom-up LC&ndash
Using Deep Learning to Extrapolate Protein Expression Measurements
2020
Mass spectrometry (MS)-based quantitative proteomics experiments typically assay a subset of up to 60% of the ≈20 000 human protein coding genes. Computational methods for imputing the missing values using RNA expression data usually allow only for imputations of proteins measured in at least some of the samples. In silico methods for comprehensively estimating abundances across all proteins are still missing. Here, a novel method is proposed using deep learning to extrapolate the observed protein expression values in label-free MS experiments to all proteins, leveraging gene functional annotations and RNA measurements as key predictive attributes. This method is tested on four datasets, in…
Common Factors in Neurodegeneration: A Meta-Study Revealing Shared Patterns on a Multi-Omics Scale
2020
Neurodegenerative diseases such as Alzheimer&rsquo
BAG3 Proteomic Signature under Proteostasis Stress
2020
The multifunctional HSP70 co-chaperone BAG3 (BCL-2-associated athanogene 3) represents a key player in the quality control of the cellular proteostasis network. In response to stress, BAG3 specifically targets aggregation-prone proteins to the perinuclear aggresome and promotes their degradation via BAG3-mediated selective macroautophagy. To adapt cellular homeostasis to stress, BAG3 modulates and functions in various cellular processes and signaling pathways. Noteworthy, dysfunction and deregulation of BAG3 and its pathway are pathophysiologically linked to myopathies, cancer, and neurodegenerative disorders. Here, we report a BAG3 proteomic signature under proteostasis stress. To elucidat…