Search results for " optimization"
showing 10 items of 2367 documents
Amorphous Ropinirole-Loaded Mucoadhesive Buccal Film: A Potential Patient-Friendly Tool to Improve Drug Pharmacokinetic Profile and Effectiveness
2020
Nowadays the therapeutic strategies to manage Parkinson&rsquo
Impulsively-controlled systems and reverse dwell time: A linear programming approach
2015
We present a receding horizon algorithm that converges to the exact solution in polynomial time for a class of optimal impulse control problems with uniformly distributed impulse instants and governed by so-called reverse dwell time conditions. The cost has two separate terms, one depending on time and the second monotonically decreasing on the state norm. The obtained results have both theoretical and practical relevance. From a theoretical perspective we prove certain geometrical properties of the discrete set of feasible solutions. From a practical standpoint, such properties reduce the computational burden and speed up the search for the optimum thus making the algorithm suitable for th…
Quantized Dissensus in Networks of Agents subject to Death and Duplication
2012
Dissensus is a modeling framework for networks of dynamic agents in competition for scarce resources. Originally inspired by biological cells behaviors, it fits also marketing, finance and many other application areas. Competition is often unstable in the sense that strong agents, those having access to large resources, gain more and more resources at the expense of weak agents. Thus, strong agents duplicate when reaching a critical amount of resources, whereas weak agents die when loosing all their resources. To capture all these phenomena we introduce systems with a discrete time gossip and unstable state dynamics interrupted by discrete events affecting the network topology. Invariancy o…
A Branch-and-Cut method for the Capacitated Location-Routing Problem
2011
International audience; Recent researches in the design of logistic networks have shown that the overall distribution cost may be excessive if routing decisions are ignored when locating depots. The Location-Routing Problem (LRP) overcomes this drawback by simultaneously tackling location and routing decisions. The aim of this paper is to propose an exact approach based on a Branch-and-Cut algorithm for solving the LRP with capacity constraints on depots and vehicles. The proposed method is based on a zero-one linear model strengthened by new families of valid inequalities. The computational evaluation on three sets of instances (34 instances in total), with 5–10 potential depots and 20–88 …
Mode-superposition correction method for deterministic and stochastic analysis of structural systems
2001
The role played by the modal analysis in the framework of structural dynamics is fundamental from both deterministic and stochastic point of view. However the accuracy obtained by means of the classical modal analysis is not always satisfactory. Therefore it is clear the importance of methods able to correct the modal response in such a way to obtain the required accuracy. Many methods have been proposed in the last years but they are meaningful only when the forcing function is expressed by an analytical function. Moreover in stochastic analysis they fail for white noise excitation. In the paper a method able to give a very accurate response for both deterministic and stochastic input is p…
Longest Common Subsequence from Fragments via Sparse Dynamic Programming
1998
Sparse Dynamic Programming has emerged as an essential tool for the design of efficient algorithms for optimization problems coming from such diverse areas as Computer Science, Computational Biology and Speech Recognition [7,11,15]. We provide a new Sparse Dynamic Programming technique that extends the Hunt-Szymanski [2,9,8] paradigm for the computation of the Longest Common Subsequence (LCS) and apply it to solve the LCS from Fragments problem: given a pair of strings X and Y (of length n and m, resp.) and a set M of matching substrings of X and Y, find the longest common subsequence based only on the symbol correspondences induced by the substrings. This problem arises in an application t…
A computational study of LP-based heuristic algorithms for two-dimensional guillotine cutting stock problems
2002
In this paper we develop and compare several heuristic methods for solving the general two-dimensional cutting stock problem. We follow the Gilmore-Gomory column generation scheme in which at each iteration a new cutting pattern is obtained as the solution of a subproblem on one stock sheet. For solving this subproblem, in addition to classical dynamic programming, we have developed three heuristic procedures of increasing complexity, based on GRASP and Tabu Search techniques, producing solutions differing in quality and in time requirements. In order to obtain integer solutions from the fractional solutions of the Gilmore-Gomory process, we compare three rounding procedures, rounding up, t…
In-Depth Analysis of Pricing Problem Relaxations for the Capacitated Arc-Routing Problem
2015
Recently, Bode and Irnich [Bode C, Irnich S (2012) Cut-first branch-and-price-second for the capacitated arc-routing problem. Oper. Res. 60(5):1167–1182] presented a cut-first branch-and-price-second algorithm for solving the capacitated arc-routing problem (CARP). The fundamental difference to other approaches for exactly solving the CARP is that the entire algorithm works directly on the typically sparse underlying graph representing the street network. This enables the use of highly efficient dynamic programming-based pricing algorithms to solve the column-generation subproblem also known as the pricing problem. The contribution of this paper is the in-depth analysis of the CARP pricing…
The Capacitated Arc Routing Problem: Lower bounds
1992
In this paper, we consider the Capacitated Arc Routing Problem (CARP), in which a fleet of vehicles, based on a specified vertex (the depot) and with a known capacity Q, must service a subset of the edges of a graph, with minimum total cost and such that the load assigned to each vehicle does not exceed its capacity. New lower bounds are developed for this problem, producing at least as good results as the already existing ones. Three of the proposed lower bounds are obtained from the resolution of a minimum cost perfect matching problem. The fourth one takes into account the vehicle capacity and is computed using a dynamic programming algorithm. Computational results, in which these bounds…
Effective Handling of Dynamic Time Windows and Its Application to Solving the Dial-a-Ride Problem
2015
A dynamic time window relates to two operations that must be executed within a given time meaning that the difference between the points in time when the two operations are performed is bounded from above. The most prevalent context of dynamic time windows is when precedence is given for the two operations so that it is a priori specified that one operation must take place before the other. A prominent vehicle routing problem with dynamic time windows and precedence is the dial-a-ride problem (DARP), where user-specified transportation requests from origin to destination points must be serviced. The paper presents a new branch-and-cut-and-price solution approach for the DARP, the prototypi…