Search results for " parkin"
showing 10 items of 122 documents
Is trans-cranial MR-guided Focused UltraSound a repeatable treatment option? Report of a successfully re-treated patient
2018
Background: In recent years, transcranial Magnetic Resonance-guided Focused UltraSounds (tcMRgFUS) treatments for functional neurological disorders are giving a new thrust to the field of therapeutic brain lesioning. This technique has been proven safe and effective in selected patients. Here we present the case of a patient affected by tremor combined with parkinsonism who underwent a second tcMRgFUS thalamotomy because of relapsing tremor after a few months from the first tcMRgFUS treatment. Materials and Methods: A 72-year-old, right-handed man, who came to our observation because of a disabling tremor affecting mainly his upper right limb and refusing any invasive surgical procedure. Hi…
Terapia trans-cranica ad ultrasuoni focalizzati guidati da Risonanza Magnetica (tcMRgFUS): studio di parcellizzazione talamica per l'identificazione …
2018
Scopo La tcMRgFUS consente di effettuare una vera e propria esplorazione neurofunzionale per confermare ed ottimizzare il target lesionale prima di indurre una lesione cerebrale permanete. La scelta del target di trattamento si basa tuttavia su coordinate stereotassiche che non tengono conto delle diversità anatomiche di ciascun individuo. L'ottimizzazione del target viene effettuata sulla base del feedback del paziente durante la procedura stessa. Scopo di questo lavoro è valutare il possibile ruolo della parcellizzazione talamica per l'identificazione del nucleo ventrale intermedio (VIM) in pazienti sottoposti a tcMRgFUS. Materiali e metodi È’ stato utilizzato uno scanner RM da 1,5T per a…
Mitochondrial DNA TRNACYS mutation in a family with frontotemporal dementia and Parkinson’s disease
2010
D2R striatopallidal neurons inhibit both locomotor and drug reward processes.
2009
The specific functions of dopamine D(2) receptor-positive (D(2)R) striatopallidal neurons remain poorly understood. Using a genetic mouse model, we found that ablation of D(2)R neurons in the entire striatum induced hyperlocomotion, whereas ablation in the ventral striatum increased amphetamine conditioned place preference. Thus D(2)R striatopallidal neurons limit both locomotion and, unexpectedly, drug reinforcement.
Electrophysiological correlates of time discrimination in Parkinson's Disease
2011
Smart parking system - another way of sharing economy provided by private institutions
2018
This paper presents our smart parking solution implemented at “Lucian Blaga” University of Sibiu (LBUS) Romania, which consists in a hardware / software embedded system for managing the institution’s parking lots, namely sharing the parking places in excess for people who are in traffic in neighbourhood of LBUS and are looking to park. Our solution is flexible, universal, applicable to all faculties that have car parks from Romania and not only, in university cities where the crowd is bigger, but also to other private institutions that own parking spaces inefficiently exploited. The advantages introduced are primarily economic, then social and even environmental. The first benefit is econom…
Use of virtual reality to explore the decision making in obsessive–compulsive disorder and Parkinson’s disease
2013
Microglia and α-synuclein implication in Parkinson's disease
2011
Age-related neurodegenerative disorders like Parkinson’s disease take an enormous toll on individuals and on society. Despite extensive efforts, Parkinson’s disease remains incurable and only very limited treatments exist. Indeed, Parkinson’s pathogenesis is still not clear and research on its molecular mechanisms is ongoing. In this study, we focused our interest on two abnormal events occurring in Parkinson’s patients, namely α-synuclein aggregation and microglial activation. We first investigated α-synuclein and its abnormal polymerisation. For this purpose, we developed novel methods, which allowed the in vitro production of different types of α-synuclein oligomers. Using highly sensiti…
Formation of covalent di-tyrosine dimers in recombinant α-synuclein
2015
Parkinson's disease is associated with fibril deposition in the diseased brain. Misfolding events of the intrinsically disordered synaptic protein α-synuclein are suggested to lead to the formation of transient oligomeric and cytotoxic species. The etiology of Parkinson's disease is further associated with mitochondrial dysfunction and formation of reactive oxygen species. Oxidative stress causes chemical modification of native α-synuclein, plausibly further influencing misfolding events. Here, we present evidence for the spontaneous formation of covalent di-tyrosine α-synuclein dimers in standard recombinant protein preparations, induced without extrinsic oxidative or nitrative agents. The…