D2R striatopallidal neurons inhibit both locomotor and drug reward processes.

6533b82cfe1ef96bd128ebe5

RESEARCH PRODUCT

D2R striatopallidal neurons inhibit both locomotor and drug reward processes.

Stefania Guiducci Pierre F Durieux Michele Zoli Ari Waisman Alban De Kerchove D'exaerde Bertrand Bearzatto Thorsten Buch Serge N. Schiffmann

subject

Time Factors striatum Parkinson's disease Striatum Neurons -- drug effects Enkephalins -- metabolism 10263 Institute of Experimental Immunology Mice Dopamine Uptake Inhibitors Tyrosine 3-Monooxygenase -- genetics Corpus Striatum -- cytology Diphtheria Toxin Glutamate Decarboxylase -- metabolism striatum; indirect opathway; A2A receptors; D2 receptors; locomotion; amphetamine addiction; Parkinson's disease Neurons amphetamine addiction Glutamate Decarboxylase General Neuroscience Amphetamine -- pharmacology Neurodegeneration 2800 General Neuroscience Enkephalins Sciences bio-médicales et agricoles locomotion medicine.anatomical_structure A2A receptors Intercellular Signaling Peptides and Proteins Receptors Dopamine D2 -- metabolism Psychology Locomotion medicine.drug Heparin-binding EGF-like Growth Factor Protein Binding Globus Pallidus -- cytology Receptors Dopamine D2 -- deficiency Reinforcement Schedule Tyrosine 3-Monooxygenase Glutamate Decarboxylase -- genetics Locomotion -- genetics Intercellular Signaling Peptides and Proteins -- genetics 610 Medicine & health Mice Transgenic Nerve Tissue Proteins Diphtheria Toxin -- pharmacology Globus Pallidus Neurons -- physiology Locomotion -- drug effects Reward Dopamine Dopamine receptor D2 medicine Nerve Tissue Proteins -- metabolism Animals Gene Expression Regulation -- genetics Amphetamine D2 receptors Receptors Adenosine A2 Receptors Dopamine D2 indirect opathway Ventral striatum Receptors Adenosine A2 -- genetics Dopamine Uptake Inhibitors -- pharmacology medicine.disease Conditioned place preference Corpus Striatum Mice Inbred C57BL Gene Expression Regulation -- drug effects Amphetamine nervous system Gene Expression Regulation Protein Binding -- drug effects Tyrosine 3-Monooxygenase -- metabolism 570 Life sciences; biology Autoradiography Conditioning Operant Neuron Conditioning Operant -- physiology Neuroscience Enkephalins -- genetics

description

The specific functions of dopamine D(2) receptor-positive (D(2)R) striatopallidal neurons remain poorly understood. Using a genetic mouse model, we found that ablation of D(2)R neurons in the entire striatum induced hyperlocomotion, whereas ablation in the ventral striatum increased amphetamine conditioned place preference. Thus D(2)R striatopallidal neurons limit both locomotion and, unexpectedly, drug reinforcement.

year	journal	country	edition	language
2009-01-01	Nature neuroscience

10.1038/nn.2286 https://pubmed.ncbi.nlm.nih.gov/19270687