Search results for " polymorphisms"

showing 3 items of 113 documents

Association of interleukin-10G microsatellite polymorphism with the susceptibility of ankylosing spondylitis

2013

Study suggests an association of IL10.G poly- morphisms with AS which might contribute to the increased or decreased susceptibility to AS. IL10.G8 and G7 microsatellites alleles appear as protective alleles against the development of AS in the German subjects investigated here. Allele IL10.G9 seems to be a risk factor for the development of AS. This protective effect of variant promoter alleles could be related to differences in IL- 10 production, which may be clinically relevant.

musculoskeletal diseasesAdultMalechemical and pharmacologic phenomenaRheumatologyimmune system diseasesparasitic diseasesmedicineHumansGenetic Predisposition to DiseaseSpondylitis AnkylosingAnkylosing spondylitisPolymorphism Geneticbusiness.industryIL10 microsatellite polymorphisms ankylosing spondylitisInterleukinhemic and immune systemsJoint boneMiddle Agedmedicine.diseaseInterleukin-10Interleukin 10ImmunologyMicrosatelliteFemalebusinessAnkylosing spondylitis; Interleukin-10; Microsatellite polymorphismsMicrosatellite RepeatsJoint Bone Spine
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Genomic Tools for the Characterization of Local Animal Genetic Resources: Application in Mascaruna Goat

2022

Italy contains a large number of local goat populations, some of which do not have a recognized genetic structure. The “Mascaruna” is a goat population reared for milk production in Sicily. In this study, a total of 72 individuals were genotyped with the Illumina Goat_IGGC_65K_v2 BeadChip with the aim to characterize the genetic diversity, population structure and relatedness with another 31 Italian goat populations. The results displayed a moderate level of genetic variability for Mascaruna, in concordance with the estimated values for Italian goats. Runs of homozygosity islands are linked to genes involved in milk production, immune response and local adaptation. Population structure anal…

single nucleotide polymorphismsSettore AGR/17 - Zootecnica Generale E Miglioramento Geneticolocal goat; single nucleotide polymorphisms; genetic structuregenetic structure local goat single nucleotide polymorphismsGeneral Veterinarygenetic structureAnimal Science and Zoologylocal goat
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Genetic variability at αs2-casein gene in Girgentana dairy goat breed

2014

Casein genes are highly polymorphic and the high degree of variability has qualitative and quantitative effects on milk composition thereby affecting chemical, physical and technological properties of goat milk. The aim of this work was to evaluate the genetic polymorphisms of the αs2-casein (CSN1S2) gene in the endangered Girgentana dairy goat breed in order to assess the genotypes distribution, as it is known genotype influences technological and nutritional milk properties. The study was performed on 207 sample of Girgentana goat breed, analysed with different PCR protocols. The most frequent alleles was A (0.722), followed by F (0.225), C (0.051) and E (0.002) while B, D and 0 alleles w…

αs2-casein gene Genetic polymorphisms Girgentana goat Milk production040301 veterinary sciencesCSN1S2 Genetic polymorphisms Girgentana goat Milk production0402 animal and dairy science04 agricultural and veterinary sciencesBiology040201 dairy & animal scienceBreedGirgentana goat breed0403 veterinary scienceSettore AGR/17 - Zootecnica Generale E Miglioramento GeneticoAnimal scienceCaseinGenotypeHigh fatAnimal Science and ZoologyGenetic variabilitylcsh:Animal cultureAlleleGenelcsh:SF1-1100Italian Journal of Animal Science
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