Search results for " precision"
showing 10 items of 145 documents
Development and implementation of the AIDA International Registry for patients with Behçet's disease
2022
AbstractPurpose of the present paper is to point out the design, development and deployment of the AutoInflammatory Disease Alliance (AIDA) International Registry dedicated to pediatric and adult patients with Behçet’s disease (BD). The Registry is a clinical physician-driven non-population- and electronic-based instrument implemented for the retrospective and prospective collection of real-life data about demographics, clinical, therapeutic, laboratory, instrumental and socioeconomic information from BD patients; the Registry is based on the Research Electronic Data Capture (REDCap) tool, which is thought to collect standardised information for clinical real-life research, and has been rea…
Comparison of UV and charged aerosol detection approach in pharmaceutical analysis of statins
2009
Abstract CAD (charged aerosol detector) has recently become a new alternative detection system in HPLC. This detection approach was applied in a new HPLC method for the determination of three of the major statins used in clinical treatment—simvastatin, lovastatin and atorvastatin. The method was optimized and the influence of individual parameters on CAD response and sensitivity was carefully studied. Chromatography was performed on a Zorbax Eclipse XDB C18 (4.6 mm × 75 mm, 3.5 μm), using acetonitrile and formic acid 0.1% as mobile phase. The detection was performed using both CAD (20 pA range) and DAD (diode array detector—238 nm) simultaneously connected in series. In terms of linearity, …
Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging
2021
Abstract Background Biological aging estimators derived from DNA methylation data are heritable and correlate with morbidity and mortality. Consequently, identification of genetic and environmental contributors to the variation in these measures in populations has become a major goal in the field. Results Leveraging DNA methylation and SNP data from more than 40,000 individuals, we identify 137 genome-wide significant loci, of which 113 are novel, from genome-wide association study (GWAS) meta-analyses of four epigenetic clocks and epigenetic surrogate markers for granulocyte proportions and plasminogen activator inhibitor 1 levels, respectively. We find evidence for shared genetic loci ass…
Valutazione di sistemi GPS e DGPS combinati con metodi di correzione e sistemi non satellitari
2000
The aim of this work is assess the accuracy of three positiotining systems: a hand-held GPS receiver, tested on itself and together with a pseudo-differential method; a DGPS system; a dead reckoning system. Test results suggest that, for row crops, the "corrected" GPS, the DGPS and the dead reckoning systems satisfy the accuracy requirement for mapping in post-processing soil and crop parameters. It is possible to improve the reliability of position resolution, by using a combined DGPS-dead reckoning system that overcomes the problems of signal weakening and obstruction.
Personalized medicine for allergy treatment: Allergen immunotherapy still a unique and unmatched model
2021
International audience; The introduction of personalized medicine (PM) has been a milestone in the history of medical therapy, because it has revolutionized the previous approach of treating the disease with that of treating the patient. It is known today that diseases can occur in different genetic variants, making specific treatments of proven efficacy necessary for a given endotype. Allergic diseases are particularly suitable for PM, because they meet the therapeutic success requirements, including a known molecular mechanism of the disease, a diagnostic tool for such disease, and a treatment blocking the mechanism. The stakes of PM in allergic patients are molecular diagnostics, to dete…
un approccio teorico-sperimentale per la ricostruzione del profilo trasversale di rotaie usurate
2012
La sovrastruttura ferroviaria durante la sua vita utile è sottoposta oltre ai carichi dinamici generati dai rotabili (azioni verticali, laterali, ecc.), anche ai carichi termici e ad azioni ambientali di varia natura. Tali sollecitazioni, interagendo sinergicamente tra loro, determinano il deterioramento della sovrastruttura ferroviaria inteso come discostamento dalla configurazione geometrica di progetto e l’usura dei singoli componenti del binario e della massicciata. Per valutare lo stato di efficienza della sovrastruttura è consuetudine far riferimento ad alcuni parametri geometrici del binario che, peraltro, permettono di formulare un giudizio oggettivo circa il livello di sicurezza of…
Statistical methods for the comparison of measurements derived from orthodontic imaging
2000
Biometric comparison procedures for dental imaging methods with continuous outcome were reviewed, mainly concentrating on assessment and comparison of accuracy and precision according to the study design. Univariate graphical and numerical representations of corresponding deviations were summarized to derive a 'check list' of minimum information necessary to compare the measurement methods. The methods reviewed in this investigation are illustrated by the comparison of conventional (radiographic) cephalometry versus assessment using the DigiGraph in 50 female children. A paired t-test and the corresponding confidence interval approach were used to assess deviations in location of two imagin…
The frontiers of the virtual photons program at MAMI
2012
The most recent results and the future physics program of the high precision electron-scattering experiment at MAMI are briefly outlined. The A1 high-resolution spectrometers facility allows for a unique quality of virtual photon experiments. High precision form factor measurements, few-baryon systems highresolution structure studies and the innovative way in the search of dark photons illustrate the interplay between such diverse fields as precision atomic physics, nuclear astrophysics and astroparticle physics, where hadron physics plays a central and connecting role.
Temperature-based and radiance-based validations of the V5 MODIS land surface temperature product
2009
[1] The V5 level 2 land surface temperature (LST) product of the Moderate Resolution Imaging Spectroradiometer (MODIS) was validated over homogeneous rice fields in Valencia, Spain, and the Hainich forest in Germany. For the Valencia site, ground LST measurements were compared with the MOD11_L2 product in the conventional temperature-based (T-based) method. We also applied the alternative radiance-based (R-based) method, with in situ LSTs calculated from brightness temperatures in band 31 through radiative transfer simulations using temperature and water vapor profiles and surface emissivity data. At the Valencia site, profiles were obtained from local radiosonde measurements and from Natio…
Nano-hygroscopicity tandem differential mobility analyzer (nano-HTDMA) for investigating hygroscopic properties of sub-10 nm aerosol nanoparticles
2020
Interactions between water and nanoparticles are relevant for atmospheric multiphase processes, physical chemistry, and materials science. Current knowledge of the hygroscopic and related physicochemical properties of nanoparticles, however, is restricted by the limitations of the available measurement techniques. Here, we present the design and performance of a nano-hygroscopicity tandem differential mobility analyzer (nano-HTDMA) apparatus that enables high accuracy and precision in hygroscopic growth measurements of aerosol nanoparticles with diameters less than 10 nm. Detailed methods of calibration and validation are provided. Besides maintaining accurate and stable sheath and a…