Search results for " present"
showing 10 items of 566 documents
Architectures “on ruins” and ambiguous transparency: the glass in preservation and communication of archaeology
2008
Abstract The contemporary architecture is characterized by an even more marked transparency, as a result of a continuous experimentation all directed towards the search of the built “lightness”, that is towards the “dematerialization” of the architecture and the consequent loss of weight connected to the excess of form. It is in 1851 that a New Architectural Age springs because of the realization of the Crystal Palace, in London – that has addressed towards the experimentation of the glass as an architectural, structural element and of design. Today, part of this experimentation has been applied for some interventions of coverage, protection and communication in situ of the archaeological r…
Anti-adrenergic effects of ranolazine in isolated rat aorta
2014
Ranolazine, a piperazine derivative, is used as an anti- anginal drug to treat patients with chronic angina in clinical practice [1] and may improve coronary blood flow by reducing compression effects of ischemic contracture, and by improving endothelial function [2],[3]. In the present study we investigate the vascular effects of ranolazine on the endothelium, adrenergic system and Ca2+ in isolated rat aorta.
Adverse drug reaction and organ damage: the liver
2016
Drug-induced liver injury (DILI) is among the most challenging acute or chronic liver conditions to be handled by physicians. Despite its low incidence in the general population, DILI is a frequent cause of acute liver failure. As such, the possibility of DILI should be considered in all patients who present with acute liver damage, independent of any known pre-existing liver disease. DILI can be classified as intrinsic/dose-dependent (e.g., acetaminophen toxicity) or idiosyncratic/dose-independent, with the latter form being relatively uncommon. Amoxicillin-clavulanate is the antimicrobial that is most frequently associated with idiosyncratic DILI. Large, ongoing, prospective studies in we…
Risk assessment and profit sharing in business networks
2011
Abstract Nowadays network is the preferred governance form to conduct economic transactions. Network solution allows to reach flexibility maintaining cost and quality level. Since network concept refers to a great variety of organizational hybrids it is possible to choose the one that fits better market requirements. The new trends in inter-organization relationships push towards network solutions: companies are interested in relationships with partners and customers to overcome resource dependence, to enter too risky market or simply differentiate their business portfolio. The proposed research focuses on the network concept aiming at highlighting threats and opportunities to investigate t…
Relationship between students' perception of a rubric for oral presentations and their academic characteristics
2022
The use of rubrics in the evaluation of oral presentations has been associated with several benefits for students. However, it is unknown whether students with better academic marks and greater self-regulation find the use of rubrics more useful or not. This paper aims to assess the relationship between how students perceive the use of a rubric and their academic characteristics, and to analyze the congruence between the professor’s and students’ evaluations when using the rubric. Eighty-five students studying for a Degree in Sport Sciences participated in this study. A rubric for oral presentations was used to assess the students’ performance. The students then filled out…
La transición a la sostenibilidad como objetivo urgente para la superación de la crisis sistémica actual
2016
Este trabajo pretende contribuir a cuestionar la creencia, ampliamente extendida entre la ciudadanía, los responsables políticos, e incluso entre los educadores, de que la transición a la Sostenibilidad es un objetivo para el futuro, que puede esperar ante las necesidades urgentes del presente. Se intenta mostrar que, por el contrario, dicha transición es necesaria ahora para dar solución a graves problemas interconectados, que amenazan ya seriamente a la presente generación, como el cambio climático, la pérdida de biodiversidad, el agotamiento de recursos fundamentales, o la pobreza y el desempleo masivo que destruyen la cohesión social. Se puede de este modo dar respuesta hoy a las necesi…
A noninflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis.
2019
Precision therapy for immune tolerance Autoimmune diseases, such as multiple sclerosis (MS), result from a breach of immunological self-tolerance and tissue damage by autoreactive T lymphocytes. Current treatments can cause systemic immune suppression and side effects such as increased risk of infections. Krienke et al. designed a messenger RNA vaccine strategy that lacks adjuvant activity and delivers MS autoantigens into lymphoid dendritic cells. This approach expands a distinct type of antigen-specific effector regulatory T cell that suppresses autoreactivity against targeted autoantigens and promotes bystander suppression of autoreactive T cells against other myelin-specific autoantigen…
Dendritic Cells Ameliorate Autoimmunity in the CNS by Controlling the Homeostasis of PD-1 Receptor+ Regulatory T Cells
2012
SummaryMature dendritic cells (DCs) are established as unrivaled antigen-presenting cells (APCs) in the initiation of immune responses, whereas steady-state DCs induce peripheral T cell tolerance. Using various genetic approaches, we depleted CD11c+ DCs in mice and induced autoimmune CNS inflammation. Unexpectedly, mice lacking DCs developed aggravated disease compared to control mice. Furthermore, when we engineered DCs to present a CNS-associated autoantigen in an induced manner, we found robust tolerance that prevented disease, which coincided with an upregulation of the PD-1 receptor on antigen-specific T cells. Additionally, we showed that PD-1 was necessary for DC-mediated induction o…
Economic evaluation on the use of reconfiguration systems for increase of energy production in PV plants
2016
This paper presents an economic analysis of the effectiveness of Dynamic Reconfiguration Systems (DRS) for PV plants in dependence of the incentive policies offered by several countries of the European Community. This evaluation has been achieved by means of the NPV (Net Present Value) and through the comparison between Bulgaria, Romania, Greece and Croatia. From the obtained results, it can be stated that the adoption of reconfiguration systems, in certain cases, can be a convenient solution.
Concurrent optimization of size and switch-on priority of a multisource energy system for a commercial building application
2015
Abstract In recent years, the governments of most nations have pledged to (i) limit carbon dioxide emissions, (ii) reduce primary energy consumption by increasing production, distribution and end-use efficiency and (iii) increase the utilization of renewable energy sources. In general, these goals are pursued separately by law, by subsidizing renewable energy technologies, reducing the demand or using high efficiency technologies. In this context, multi-source systems for the fulfillment of energy demands are highly advantageous because they are based on different technologies which use renewable, partially renewable and fossil energy sources. However, the main issues of multi-source system…