Search results for " present"
showing 10 items of 566 documents
Medium term effects of a ketogenic diet and a Mediterranean diet on resting energy expenditure and respiratory ratio
2012
Background Very low carbohydrate ketogenic type diets (VLCKD) have been shown to be more effective for body weight reduction and fat loss compared to balanced or low-calorie Mediterranean diets, at least in the short-medium term [1,2], although the underlying mechanisms of its efficacy are still not well understood. Despite being a diet in widespread use there are few data available regarding effects on respiratory ratio (RR) [3,4] and resting energy expenditure (REE) and, more specifically, there are no reports about the effects on RR following a return to a non ketogenic diet. The aim of this study was to compare the effects of a 20 day ketogenic Mediterranean diet with phytoextracts (KEM…
A fully synthetic glycopeptide antitumor vaccine based on multiple antigen presentation on a hyperbranched polymer.
2014
For antitumor vaccines both the selected tumor-associated antigen, as well as the mode of its presentation, affect the immune response. According to the principle of multiple antigen presentation, a tumor-associated MUC1 glycopeptide combined with the immunostimulating T-cell epitope P2 from tetanus toxoid was coupled to a multi-functionalized hyperbranched polyglycerol by "click chemistry". This globular polymeric carrier has a flexible dendrimer-like structure, which allows optimal antigen presentation to the immune system. The resulting fully synthetic vaccine induced strong immune responses in mice and IgG antibodies recognizing human breast-cancer cells.
Potencialidades de Google Maps en la investigación social aplicada
2019
In recent years, Google has devoted resources to build a complete map of the world. They constantly scan the territory, collecting a large amount of data that provides updated and complete geographic information. This allows us to have an interoperable map that provides the end user with a search tool, not only of routes but also of shops, equipment and any type of geo-referenced information. In addition, Google Maps provides a series of Application Programming Interface (API), which provides a library of set of subroutines, functions and procedures (in object-oriented programming) that can be used by other software to automate the extraction of information of the Google platform. These fre…
Present participles in the new Gothic palimpsest
2015
A new Gothic text has recently been discovered and it is contained in a palimpsest bifolium of the Archive of the Board of Trustees of San Petronio’s Basilica in Bologna. Two scholars of Milan, R. Bianca Finazzi and Paola Tornaghi, have studied the palimpsest. The author received their paper directly from the two colleagues, who had received word of the interest the discovery of the new Gothic text had kindled in him. In his examination of the text, the author was able to find two cases confirming and one supplementing what he had written in Melazzo (1992) about the two different Gothic forms of the nominative singular of the present participle in the masculine, of which one ends in -ndaand…
On the relation between present and future tense in Lithuanian: Preliminary considerations in the domain of non-deictic tense use
2021
The article examines non-deictic uses of present and future tense in Lithuanian. Narrative use, in which reference intervals match with singular events, is distinguished from suspended propositions characterized by lack of such reference intervals (habitual, dispositional and circumstantial modal, and conditional meanings). Present tense is frequently involved in both usage domains, while the future is rare in narrative use, but overlaps with present tense in certain types of suspended propositions. Moreover, its temporal-deictic use is inherently associated with suspended propositions and “linked” to them via epistemic implicatures. This, in contrast to the present, makes the future more l…
Quantification of CD8+ T lymphocytes responsive to human immunodeficiency virus (HIV) peptide antigens in HIV-infected patients and seronegative pers…
1998
/ T cells responding to HIV-1 peptides were observed in none of 11 HIV- seronegative donors without a history of HIV exposure. ELISPOT assays are relatively fast and easy to perform and appear to reliably detect T cell reactivity due to previous exposure to HIV. These findings support the use of the ELISPOT assay for monitoring T cell responsiveness to HIV peptides. In acute infection with the human immunodeficiency virus We described recently an enzyme-linked immunospot (ELISPOT) assay to detect and quantitate single blood-de- type 1 (HIV-1), initial reduction in virus load is associated with the appearance of a high frequency of antiviral cytotoxic T rived CD8 / T lymphocytes forming tumo…
Behavior of a Short preS1 Epitope on the Surface of Hepatitis B Core Particles
1999
The major immunodominant region of hepatitis B core particles is widely recognized as the most prospective target for the insertion of foreign epitopes, ensuring their maximal antigenicity and immunogenicity. This region was mapped around amino acid residues 79-81, which were shown by electron cryo-microscopy to be located on the tips of the spikes protruding from the surface of hepatitis B core shells. Here we tried to expose a model sequence, the short immunodominant hepatitis B preS1 epitope 31-DPAFR-35, onto the tip of the spike, with simultaneous deletion of varying stretches from the major immunodominant region of the HBc molecule. Accessibility to the monoclonal anti-preS1 antibody M…
Overionization in X-ray spectra: a new paradigm for Mixed-Morphology SNRs
2011
Mixed-morphology SNRs are characterized by a shell-like radio emission, a centrally peaked X-ray morphology, and by interaction with molecular clouds. Many models have been proposed to explain these peculiar remnants, but their physical origin is still unclear. The recent discovery of over-ionized (i. e. recombining) ejecta in 3 mixed-morphology SNRs has dramatically challenged all the previous models and opened up new, unexpected scenarios. I review the main properties of these remnants and their peculiar X-ray spectral properties. I also discuss the hydrodynamic model developed to explain the presence of over-ionized ejecta in W49B and present a list of open issues that still need to be c…
Antigens and immunoevasins: opponents in cytomegalovirus immune surveillance
2002
CD8+ T cells are the main effector cells for the immune control of cytomegaloviruses. To subvert this control, human and mouse cytomegaloviruses each encode a set of immune-evasion proteins, referred to here as immunoevasins, which interfere specifically with the MHC class I pathway of antigen processing and presentation. Although the concerted action of immunoevasins prevents the presentation of certain viral peptides, other viral peptides escape this blockade conditionally or constitutively and thereby provide the molecular basis of immune surveillance by CD8+ T cells. The definition of viral antigenic peptides that are presented despite the presence of immunoevasins adds a further dimens…
Human cytomegalovirus pp71 stimulates major histocompatibility complex class i presentation of IE1-derived peptides at immediate early times of infec…
2013
ABSTRACT Suppression of major histocompatibility complex (MHC) class I-mediated presentation of human cytomegalovirus (HCMV) peptides is an important mechanism to avoid CD8 T lymphocyte recognition and killing of infected cells. Of particular interest is how MHC class I presentation of essential regulatory immediate early (IE) proteins of HCMV can be effectively compromised at times when known viral immunoevasins are not abundantly expressed. The tegument protein pp71 had been suggested to be involved in MHC class I downregulation. Intriguingly, this polypeptide is also critically engaged in the initial derepression of the major IE gene locus, leading to enhanced expression of IE proteins I…