Search results for " present"

showing 10 items of 566 documents

Functionally Active T Cell Receptor/CD3 Complexes Are Present at the Surface of Cloned Cytotoxic T Cells without Fluorescence-Immunological Detectabi…

1996

The cytotoxic T cell clone 10BK.1 is activated in response to the ovalbumin peptide OVA257-264 in a major histocompatibility complex class I-restricted manner. Following activation 10BK.1 cells proliferate, secrete lymphokines, and kill syn- and allogeneic target cells. Using immunofluorescence analysis we detected CD8, LFA-1, and ICAM-1 on the surface of 10BK.1 cells, but no CD3 or T cell receptor (TCR). In contrast, the proliferative response of 10BK.1 cells to antigen was efficiently blocked by soluble antibodies directed at CD3 epsilon or TCR alpha beta, but not by antibodies directed at TCR gamma delta. In addition, lysis of target cells was blocked by F(ab')2 fragments of antibodies d…

Intracellular FluidCD40biologyCD3ImmunologyT-cell receptorAntigen presentationAntigen-Presenting CellsMembrane Proteinshemic and immune systemschemical and pharmacologic phenomenaFlow CytometryLymphocyte ActivationMolecular biologyClone CellsMiceFluorescent Antibody Technique DirectReceptor-CD3 Complex Antigen T-Cellbiology.proteinInterleukin 12AnimalsCytotoxic T cellAntigen-presenting cellCD8T-Lymphocytes CytotoxicCellular Immunology
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Langerhans Cells Prevent Autoimmunity via Expansion of Keratinocyte Antigen-Specific Regulatory T Cells

2017

Langerhans cells (LCs) are antigen-presenting cells in the epidermis whose roles in antigen-specific immune regulation remain incompletely understood. Desmoglein 3 (Dsg3) is a keratinocyte cell-cell adhesion molecule critical for epidermal integrity and an autoantigen in the autoimmune blistering disease pemphigus. Although antibody-mediated disease mechanisms in pemphigus are extensively characterized, the T cell aspect of this autoimmune disease still remains poorly understood. Herein, we utilized a mouse model of CD4+ T cell-mediated autoimmunity against Dsg3 to show that acquisition of Dsg3 and subsequent presentation to T cells by LCs depended on the C-type lectin langerin. The lack of…

Keratinocytes0301 basic medicineLangerinRegulatory T cellT celllcsh:MedicineAutoimmunitymedicine.disease_causeT-Lymphocytes RegulatoryGeneral Biochemistry Genetics and Molecular BiologyAutoimmunity03 medical and health sciencesAutoimmune diseasemedicineAnimalsLectins C-TypeAntigenseducationCell ProliferationAutoimmune diseaselcsh:R5-920Antigen Presentationeducation.field_of_studyDesmoglein 3integumentary systembiologylcsh:RHistocompatibility Antigens Class IIPeripheral toleranceReceptors Interleukin-2Regulatory T cellsGeneral Medicinemedicine.diseaseCell biologyMice Inbred C57BLPemphigusMannose-Binding Lectins030104 developmental biologymedicine.anatomical_structureLangerhans CellsAntigens SurfaceDesmoglein 3biology.proteinlcsh:Medicine (General)PemphigusResearch PaperSignal TransductionEBioMedicine
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Cellular and molecular mechanisms in the induction phase of contact sensitivity.

1995

During the induction phase of contact sensitivity, hapten-specific Th1 cells are primed by epidermal Langerhans cells. These Langerhans cells present hapten on MHC class II molecules and provide costimulatory signals. This presentation discusses the induction of cytokines in Langerhans cells and keratinocytes by haptens and their regulatory effects on contact sensitivity. Haptens were painted on the skin of normal BALB/c mice and epidermal cells were prepared at various times thereafter. Langerhans cell-derived interleukin (IL)-1 beta mRNA was observed as early as 15 min after hapten paining. In keratinocytes, tumor necrosis factor-alpha, IL-1 alpha, IP-10, MIP-2 and IL-10 were found to be …

KeratinocytesImmunologyAntigen presentationCD1chemical and pharmacologic phenomenaInduction PhasePicryl ChlorideBiologyMiceCytokines metabolismCricetinaeDinitrochlorobenzeneImmune ToleranceImmunology and AllergyAnimalsNitrobenzenesMHC class IIAntigen PresentationMice Inbred BALB Cintegumentary systemHistocompatibility Antigens Class IIAntibodies MonoclonalGeneral MedicineContact sensitivityCell biologyDinitrobenzenesLangerhans CellsImmunologyDermatitis Allergic Contactbiology.proteinCytokinesDinitrofluorobenzeneAntibodyHaptenHaptensInternational archives of allergy and immunology
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Early and midterm outcomes of bioresorbable vascular scaffolds for ostial coronary lesions: insights from the GHOST-EU registry.

2016

Aims: We aimed to investigate the outcomes of bioresorbable vascular scaffolds (BVS) in coronary ostial lesions. Ostial lesions represent a challenging angiographic subset, with higher event rates compared with non-ostial lesions. BVS might be associated with advantages over the long term, but their safety in this setting remains to be explored. Methods and results: Procedural and 12-month follow-up data from consecutive patients treated with BVS for lesions located at the ostium of the right (RCA), left anterior (LAD) or circumflex (LCX) coronary in 11 European centres were collected. The primary device-oriented endpoint was defined as a combination of cardiovascular death, target vessel m…

LCX (29Target lesionMale52%). Patients presenting with ostial lesions did not differ from the remaining cohort except for a higher incidence of prior revascularisation. Predilation was performed in 97% of the lesions (vs. 96% in non-ostialp= 0.035)medicine.medical_treatmentMyocardial Infarction304 patients with a mean age of 62 +/- 11years. There were 90 ostial lesions (5.8%) in 84 patients (6.4%) located at the ostial RCA (14Coronary Artery Disease030204 cardiovascular system & hematologyCoronary artery diseasebut their safety in this setting remains to be explored. Methods and results: Procedural and 12-month follow-up data from consecutive patients treated with BVS for lesions located at the ostium of the right (RCA)0302 clinical medicineAbsorbable Implants030212 general & internal medicineMyocardial infarctionCircumflexRegistriesTissue Scaffolds32%)Drug-Eluting StentsMiddle AgedThrombosisCoronary VesselsAims: We aimed to investigate the outcomes of bioresorbable vascular scaffolds (BVS) in coronary ostial lesions. Ostial lesions represent a challenging angiographic subset with higher event rates compared with non-ostial lesions. BVS might be associated with advantages over the long term but their safety in this setting remains to be explored. Methods and results: Procedural and 12-month follow-up data from consecutive patients treated with BVS for lesions located at the ostium of the right (RCA) left anterior (LAD) or circumflex (LCX) coronary in 11 European centres were collected. The primary device-oriented endpoint was defined as a combination of cardiovascular death target vessel myocardial infarction or target lesion revascularisation. The database included a total of 1549 lesions in 1304 patients with a mean age of 62 +/- 11years. There were 90 ostial lesions (5.8%) in 84 patients (6.4%) located at the ostial RCA (14; 16%) LCX (29; 32%) or LAD (47; 52%). Patients presenting with ostial lesions did not differ from the remaining cohort except for a higher incidence of prior revascularisation. Predilation was performed in 97% of the lesions (vs. 96% in non-ostial p= 0.618) post-dilation in 43% (versus 58% in the non-ostial group p= 0.008). At quantitative coronary angiography treatment of ostial lesions was associated with higher residual stenosis (30% [23-41] vs. 26% [20-37] p= 0.035) but no difference in minimum lumen diameter existed (p= 0.447). Follow-up data were available at 385 [362-465] days. The 12-month Kaplan-Meier estimated rates of scaffold thrombosis were 4.9% and 2.0% (ostial and non-ostial lesion groups respectively log-rank p= 0.005). The device-oriented composite endpoint occurred respectively in 12.6% and 4.6% at 12 months (log-rank p= 0.001). Treatment of ostial lesions was an independent predictor of this endpoint (p= 0.0025 HR 2.65 [1.41-4.97]).OstiumAims: We aimed to investigate the outcomes of bioresorbable vascular scaffolds (BVS) in coronary ostial lesions. Ostial lesions represent a challenging angiographic subsetTreatment Outcomein 12.6% and 4.6% at 12 months (log-rank p= 0.001). Treatment of ostial lesions was an independent predictor of this endpoint (p= 0.0025CardiologyFemale549 lesions in 1medicine.symptomCardiology and Cardiovascular MedicineAdultpost-dilation in 43% (versus 58% in the non-ostial groupmedicine.medical_specialtyor LAD (47HR 2.65 [1.41-4.97])but no difference in minimum lumen diameter existed (p= 0.447). Follow-up data were available at 385 [362-465] days. The 12-month Kaplan-Meier estimated rates of scaffold thrombosis were 4.9% and 2.0% (ostial and non-ostial lesion groupsrespectivelyLesion03 medical and health sciencesPercutaneous Coronary Interventionwith higher event rates compared with non-ostial lesions. BVS might be associated with advantages over the long termleft anterior (LAD) or circumflex (LCX) coronary in 11 European centres were collected. The primary device-oriented endpoint was defined as a combination of cardiovascular deathInternal medicinemedicineHumanstarget vessel myocardial infarction or target lesion revascularisation. The database included a total of 1Agedp= 0.008). At quantitative coronary angiographybusiness.industryPercutaneous coronary interventionp= 0.618)treatment of ostial lesions was associated with higher residual stenosis (30% [23-41] vs. 26% [20-37]log-rank p= 0.005). The device-oriented composite endpoint occurredmedicine.diseaseSurgery16%)businessEuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology
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Educare con la fiaba: le differenze di genere

2020

The anthropological premise to the pedagogical treatment of fairy tales contribution to the formation of sexual and gender identity in girls and boys is the origin of sexual dimorphism that, being present in all cultures, cannot only be the result of socio-cultural conditioning. Considering the mutual cooperation between men and women and the wider family and social harmony, contemporary fairy tales and the appropriate reinterpretations of classic fairy tales have great educational potential for sexual identity development and for overcoming social stereotypes related to sex in girls and boys.

La premessa antropologica alla trattazione pedagogica del contributo delle fiabe alla formazione dell’identità sessuale e di genere nelle bambine e nei bambini è l’originarietà del dimorfismo sessuale che essendo presente in tutte le culture non può essere solo frutto di condizionamenti socio-culturali. Le fiabe contemporanee e le opportune rivisitazioni delle fiabe classiche hanno delle grandi potenzialità educative per la formazione dell’identità sessuale e per il superamento degli stereotipi sociali legati al sesso nelle bambine e nei bambini in vista della reciproca collaborazione tra l’uomo e la donna e della più ampia concordia familiare e sociale.Settore M-PED/02 - Storia Della PedagogiaSettore M-PED/03 - Didattica E Pedagogia Speciale
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Cytokines and their effects on maturation, differentiation and migration of dendritic cells.

1996

In this review the role of cytokines in the maturation and migration of phenotypically and functionally diverse dendritic cell (DC) subpopulations is discussed and their role in the progress of differentiation from bone marrow progenitors to lymphoid DC is described. GM-CSF is the most important cytokine for the development of functional DC and acts in concert with a varying mixture of other cytokines such as IL-4, IL-1 and TNF-α to direct the development of individual DC subpopulations.

Langerhans cellLymphoid Tissuemedicine.medical_treatmentCellular differentiationDermatologyDendritic cell differentiationBiologyCell MovementmedicineAnimalsHumansProgenitor cellAntigen PresentationEpidermis (botany)Stem CellsCell DifferentiationGeneral MedicineDendritic cellDendritic CellsCell biologymedicine.anatomical_structureCytokineLangerhans CellsAntigens SurfaceCytokinesBone marrowArchives of dermatological research
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Negotiation of expertise and multifunctionality : PowerPoint presentations as interactional activity types in workplace meetings

2016

This article investigates exchanges between the presenter and another participant within PowerPoint presentations in workplace meetings. Using ethnomethodological conversation analysis as a method, it examines 1) how participants orient to each other's expertise, 2) what is accomplished through the exchange and 3) how the PowerPoint slide is interwoven with the process. The results show how the exchanges establish the presentation as information delivery in which the complexity of professional knowledge is displayed and negotiated. Moreover, there is an orientation to directive functions of the presentation activity. The PowerPoint slides as a text and as a material object are evoked for th…

Linguistics and Languageconversation analysisSocial PsychologyProcess (engineering)media_common.quotation_subjectworkplace interactionta6121Experimental and Cognitive PsychologyInformation deliveryLanguage and LinguisticsEpistemicsPresentation0502 economics and businessPedagogymedia_common060201 languages & linguisticsCommunicationspeaker changebusiness.industrydeonticskeskustelunanalyysiCommunication05 social sciences06 humanities and the artsDirectiveObject (philosophy)NegotiationConversation analysis0602 languages and literatureepistemicsPsychologybusiness050203 business & managementPowerPoint presentation
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Tutorial multimedia para guiar la preparación y defensa del Trabajo de Fin de Grado

2013

La preparació i defensa d’un Treball de Fi de Grau constitueix una de les principals novetats derivades del procés de construcció de l’Espai Europeu d’Educació Superior. En aquest treball queden reflectides totes les habilitats adquirides pels estudiants en els anys previs a la finalització del Grau, ja que els estudiants han d’enfrontar-se en el mateix al procés de generació autònoma de coneixement i a les dificultats del treball pràctic. El present estudi recull l’experiència de desenvolupament d’un tutorial multimèdia per a guiar el procés de realització del Treball de Fi de Grau, adaptats als objectius d’aprenentatge i a l’adquisició de competències dels alumnes destinataris. El treball…

Lingüística Aplicada:LINGÜÍSTICA [UNESCO]Tutorial multimediaInformación y DocumentaciónLingüística Aplicada; Información y DocumentaciónTrabajo académico Destrezas de escritura Presentación oral Proyecto Fin de GradoUNESCO::LINGÜÍSTICATutorial multimedia; Trabajo académico Destrezas de escritura Presentación oral Proyecto Fin de Grado
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Congenital Hepatic Fibrosis

2005

The disease presentation of autosomal recessive polycystic kidney disease (OMIM #263200, ARPKD) is highly variable and includes polycystic kidneys, pulmonary hypoplasia, and congenital hepatic fibrosis. The authors report an unusual case of ARPKD presenting with hepatosplenomegaly and cytopenia mimicking acute leukemia.

Liver CirrhosisMalePathologymedicine.medical_specialtyAdolescentPancytopeniaHepatosplenomegalyurologic and male genital diseasesPulmonary hypoplasiahemic and lymphatic diseasesmedicineHumanscytopeniaPolycystic Kidney Autosomal RecessivesplenomegalyCytopeniaAcute leukemiapolycystic kidney diseasebusiness.industryHematologymedicine.diseasePancytopeniaeye diseasesfemale genital diseases and pregnancy complicationsAutosomal Recessive Polycystic Kidney DiseaseOncologyDisease PresentationPediatrics Perinatology and Child HealthCongenital hepatic fibrosismedicine.symptomTomography X-Ray ComputedbusinessHepatomegalyJournal of Pediatric Hematology/Oncology
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Antigen-presenting function and B7 expression of murine sinusoidal endothelial cells and Kupffer cells.

1996

Abstract BACKGROUND & AIMS: Inflammatory liver disease as well as rejection of liver allografts are thought to be mediated by resident antigen- presenting cells in the liver. At the same time, in vivo antigen presentation in the liver appears to be a more tolerogenic than systemic antigen challenge. The aim of this study was to show and characterize the antigen-presenting capability of sinusoidal endothelial cells and Kupffer cells. METHODS: Purified murine sinusoidal endothelial cells and Kupffer cells were studied for their ability to serve as accessory cells and antigen-presenting cells by proliferation assays. They were also studied for their expression of interleukin 1 and the B7 costi…

Liver cytologyKupffer CellsAntigen presentationMolecular Sequence DataAntigen-Presenting CellsBiologyLymphocyte ActivationPolymerase Chain ReactionMicemedicineAnimalsRNA MessengerAntigen-presenting cellInterleukin 3Antigen PresentationMice Inbred BALB CCD40HepatologyBase SequenceKupffer cellGastroenterologyBlotting NorthernCell biologyInterleukin-10RatsInterleukin 33medicine.anatomical_structureLiverImmunologybiology.proteinInterleukin 12B7-1 AntigenEndothelium VascularInterleukin-1Gastroenterology
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