Search results for " present"
showing 10 items of 566 documents
Major Histocompatibility Complex Class I Allele-specific Cooperative and Competitive Interactions between Immune Evasion Proteins of Cytomegalovirus
2002
Cytomegaloviruses (CMVs) deploy a set of genes for interference with antigen presentation in the major histocompatibility complex (MHC) class I pathway. In murine CMV (MCMV), three genes were identified so far: m04/gp34, m06/gp48, and m152/gp40. While their function as immunoevasins was originally defined after their selective expression, this may not necessarily reflect their biological role during infection. The three immunoevasins might act synergistically, but they might also compete for their common substrate, the MHC class I complexes. To approach this question in a systematic manner, we have generated a complete set of mutant viruses with deletions of the three genes in all seven pos…
Hypothèse de Muséalisation en plein air pour le Quartier hellénistique-romain à Agrigente / Ipotesi di musealizzazione outdoor per il Quartiere ellen…
2014
The contribution presents the results of the activities carried out as a Expert in Museography for the APER project, which included the elaboration of a Musealisation hypothesis for the Domus IA-IB of the Hellenistic-Roman quarter located in Agrigento, i.e. the definition of intervention lines to be applied in an outdoor context to help the general public understand the archaeological site concerned to. The selected museographic strategies correspond to true forms of museal memorisation, aimed at knowing how to transmit the interpretation of an ancient context and its significance to a non-specialist public. In the conclusive phase, it has developed an executive project for two museographic…
Muséaliser l’archéologie : quelques interventions innovantes pour la présentation des ruines / Musealizzare l’archeologia: alcuni interventi innovati…
2014
Intervention on archaeological sites requires a multicriteria approach, which does not lend itself to providing solutions of a general nature so much as solutions linked to the individual case at hand and to the comparison of the interventions involved in the creation of a museum-like context for them. Nevertheless, one should not lose sight of the general aspect of the problem and underestimate a series of considerations regarding what to conserve and why in favour of how to conserve, an aspect which has been extensively tested and which today offers a large range of appropriate solutions and techniques. It is a question of communication, solutions to which must be provided both through to…
Friend retrovirus infection of myeloid dendritic cells impairs maturation, prolongs contact to naïve T cells, and favors expansion of regulatory T ce…
2007
AbstractRetroviruses have developed immunmodulatory mechanisms to avoid being attacked by the immune system. The mechanisms of this retrovirus-associated immune suppression are far from clarified. Dendritic cells (DCs) have been attributed a decisive role in these pathogenic processes. We have used the Friend retrovirus (FV) mouse model in order to acquire further knowledge about the role of infection of DCs in virus-induced immunosuppression. About 20% of the myeloid DCs that were generated from the bone marrow of FV-infected mice carried FV proteins. The infection was productive, and infected DCs transmitted the virus in cell culture and in vivo. FV infection of DCs led to a defect in DC …
Neurons as targets for T cells in the nervous system
2013
International audience; Accumulating evidence shows that T cells penetrate the central nervous system (CNS) parenchyma in several autoimmune, infectious, and degenerative neurological diseases. The structural and functional consequences for CNS neurons of their encounter with activated T cells have been investigated in several experimental systems, including ex vivo co-cultures, electrophysiology, and in vivo imaging. Here, we review the modalities of neuron/T cell interactions. We substantiate the contention that T cells are directly responsible for neuronal damage in a large number of neurological diseases and discuss mechanisms of neuronal damage mediated by distinct T cell subsets, the …
Economie assessments on the use of wired and wireless recharging systems in Italian and European market
2017
The conductive charging method for the electric vehicles is the most widespread, since it is the simplest and has higher returns. In the last years, alternative charging technologies have been investigated. Between these wireless charging systems have been large diffusion and have been commercialized by some manufacturer. Wireless charging systems for electric vehicles have some advantages respect the wired ones, not obliging the user to connect physically the vehicle to the electric charging station. Assuming the efficiency declared by the manufacturer of wireless systems the authors, in this paper, estimate the maximum cost that wireless recharging systems can have to be, however, more fa…
Economic analysis on the use of wired and wireless recharging systems
2017
Wireless charging systems for electric vehicles have some advantages respect the wired ones, not obliging the user to connect physically the vehicle to the electric charging station. However, at the same time, they have disadvantages linked to issues of electromagnetic compatibility and low efficiency. This study considers some scenarios for which both wired and wireless recharging systems can be adopted, with the aim of estimate the efficiency that must be guaranteed by wireless systems, so that its realization could be more favorable with respect to wired one. The estimation is developed by means of classical economic indexes, in the framework of Italian end European markets. Results repo…
Viaggi nell’immaginario: il turismo virtuale nel sito UNESCO di Tarragona
2023
Le nuove tecnologie hanno trasformato in modo radicale non solo la geografia come disciplina, ma anche le geografie del mondo. Il digitale ha assunto, infatti, un ruolo di mediazione sempre più pervasivo nella produzione dello spazio, come delle conoscenze e degli immaginari geografici. Le possibilità offerte dal virtuale, in particolare, offrono oggi un contributo decisivo nella comunicazione dei significati attribuiti ai luoghi e rispondono in modo sempre più efficace ai bisogni emergenti del settore turistico. Le esperienze di visita mediate dal digitale mirano a coinvolgere i sensi e risultano efficaci quando promuovono immersioni rigorosamente realistiche. Nel quadro di queste riflessi…
LE DISUGUAGLIANZE TRA TERRITORI
2021
Non presente
P03.04 Signaling questions assessing brain tumor patients’ distress in clinical routine - a feasibility study
2019
Abstract BACKGROUND Approximately 20%-35% of patients with intracranial tumors show depressive symptoms and distress. Assessment in these patients remains challenging due to cognitive and/or neurological deficits. We developed 3 signaling questions in order to assess patients during patient-doctor consultation. The aim is to implement them in clinical routine and to compare the results with patient reported outcome measures (PROMs) along disease trajectory. MATERIAL AND METHODS Patients were prospectively examined in a structured interview applying the 3 following questions: 1),Has your mood worsened? (I)”; 2),Are you strained by physical changes? (II)”; 3),Has your faculty of thought decre…