Search results for " progress."
showing 10 items of 1281 documents
Osteopontin shapes immunosuppression in the metastatic niche.
2014
Abstract The matricellular protein osteopontin (OPN, Spp-1) is widely associated with cancer aggressiveness when produced by tumor cells, but its impact is uncertain when produced by leukocytes in the context of the tumor stroma. In a broad study using Spp1−/− mice along with gene silencing in tumor cells, we obtained evidence of distinct and common activities of OPN when produced by tumor or host cells in a spontaneously metastatic model of breast cancer. Different cellular localization of OPN is associated with its distinct activities, being mainly secreted in tumor cells while intracellular in myeloid cells. OPN produced by tumor cells supported their survival in the blood stream, wherea…
Tumor-Derived Small Extracellular Vesicles Induce Pro-Inflammatory Cytokine Expression and PD-L1 Regulation in M0 Macrophages via IL-6/STAT3 and TLR4…
2021
Tumor-associated macrophages play a key role in promoting tumor progression by exerting an immunosuppressive phenotype associated with the expression of programmed cell death ligand 1 (PD-L1). It is well known that tumor-derived small extracellular vesicles (SEVs) affect the tumor microenvironment, influencing TAM behavior. The present study aimed to examine the effect of SEVs derived from colon cancer and multiple myeloma cells on macrophage functions. Non-polarized macrophages (M0) differentiated from THP-1 cells were co-cultured with SEVs derived from a colorectal cancer (CRC) cell line, SW480, and a multiple myeloma (MM) cell line, MM1.S. The expression of PD-L1, interleukin-6 (IL-6), a…
Leptin and Its Receptor are Overexpressed in Brain Tumors and Correlate with the Degree of Malignancy
2009
Although leptin and its receptor (ObR) have emerged as important cancer biomarkers, the role of the leptin system in brain tumor development remains unknown. We screened 87 human brain tumor biopsies using immunohistochemistry and detected leptin and ObR in 55.2% and 60.9% cases, respectively. In contrast, leptin and ObR were absent in 14 samples of normal brain tissue. The presence of leptin correlated with ObR with overall concordance 80.5%. The leptin/ObR system was highly expressed in glioblastomas and anaplastic astrocytomas, while lower expression of both markers was noted in low-grade astrocytomas and gangliogliomas. The association between leptin/ObR and the degree of tumor malignan…
Efficacité comparée de l'enseignement public et privé au Cameroun
2010
In this thesis, we treat with the efficiency compared by the state education and by the private education in Cameroon. The current educational system carries the marks of colonial period. The school is crossed by three stages the school before the colonization, the school during the colonization and the school after the colonization. The current educational system is characterized by a strong educational request and an insufficient educational offer. The redoubling and the abandonments are frequent and raised. The educational system is little effective in general. Two educational sub-systems inherited from colonial period work, the one French speaker and the other English speaker. Two secto…
Unmet needs and gaps in the identification of secondary progression in multiple sclerosis: a Southern Italy healthcare professionals' perspective
2022
Abstract Objective Multiple sclerosis (MS) is a chronic disease with different clinical courses and a tendency to worsening. The relapsing–remitting MS presents acute onset and relapses of neurological symptoms, followed by their remission. This form can convert to secondary progressive MS (SPMS) with irreversible neurological worsening and disability. The identification of signs, symptoms, markers of progression, and strategies to manage MS patients is mandatory to allow early identification of those at higher risk of conversion to SPMS, for prompt intervention to cope with the progression of the disease. Methods A panel of Italian experts from Southern Italy have reviewed the current know…
Compromised nuclear envelope integrity drives TREX1-dependent DNA damage and tumor cell invasion
2021
Although mutations leading to a compromised nuclear envelope cause diseases such as muscular dystrophies or accelerated aging, the consequences of mechanically induced nuclear envelope ruptures are less known. Here, we show that nuclear envelope ruptures induce DNA damage that promotes senescence in non-transformed cells and induces an invasive phenotype in human breast cancer cells. We find that the endoplasmic reticulum (ER)-associated exonuclease TREX1 translocates into the nucleus after nuclear envelope rupture and is required to induce DNA damage. Inside the mammary duct, cellular crowding leads to nuclear envelope ruptures that generate TREX1-dependent DNA damage, thereby driving the …
ULTERIORI APPROFONDIMENTI DEGLI EFFETTI DELLA DIMENSIONE DEGLI ACINI SULLA QUALITA’ DELL’UVA NELLA CV CABERNET SAUVIGNON
2012
In this study we reported the results of a second year of study conducted during 2008 season on irrigated Cabernet Sauvignon\ 1103 P vineyard. We addressed the study of whether differences in berry size (within a population of berries from different bunches) would lead to differences in qualitative parameters and whether flowering process can influence berries variability and qualitative parameters. Berries were classified at pea size into two categories according to their equatorial diameter: ≤ 7 mm as small and ≥ 9 mm as large berries. Development of the two berry categories was evaluated from “pea size” (12th June) to harvest (16th September) in terms of berry mass, equatorial berry diam…
La città di Alphabet. Architettura per prosumers.
2021
Attraverso alcuni aspetti salienti dell’ideazione, della produzione e dell’opposizione al progetto del Toronto Quayside di Sidewalk labs, l’articolo discute l’influenza delle infrastrutture digitali per l’informazione sul progetto della casa e del quartiere. L’ampliamento delle attività svolte da remoto nello spazio domestico, enfatizzato dal quotidiano della pandemia da Covid 19, costituisce per gli oligopolisti planetari degli urban data come Alphabet un utile volano pubblicitario e un acceleratore. La fusione dei nuovi vessilli della tecnoemancipazione e della sostenibilità in ipotesi sperimentali che mirano a costruirsi sia per intero che per parti realizza un nuovo orizzonte in cui lo …
Bando di concorso: profili sostanziali e problemi di giurisdizione
2022
Il contributo fornisce una sintesi delle principali questioni che riguardano il bando di concorso nell’impiego pubblico privatizzato, mostrando attenzione alle clausole immediatamente lesive rappresentate dai requisiti discriminatori, in presenza dei quali si prospetta la possibilità di utilizzare lo strumento di tutela previsto dall’art. 28 del d.lgs. n. 150/2011, in alternativa al ricorso al giudice amministrativo. Con riguardo al riparto di giurisdizione vengono analizzati i principali nodi problematici in materia di progressioni verticali e di scorrimento delle graduatorie. The essay summarises most relevant issues on competition announcement in privatised public employment law, with a …
Prospettive di riforma della tutela penale dell'ambiente nel diritto europeo e sovranazionale
2021
Il saggio descrive le prospettive di riforma della normativa penale ambientale, di recente delineatesi tanto a livello internazionale, quanto in ambito europeo. Pur non spingendosi sino a prevedere i possibili esiti delle dinamiche in corso, il contributo non rinuncia ad analizzarne luci ed ombre, anche alla luce delle difficoltà di tipizzazione delle fattispecie incriminatrici determinata dalla particolare complessità della materia ambientale.