Search results for " progress"
showing 10 items of 1287 documents
EXPERIMENTAL INVESTIGATION OF DILUTE SOLID-LIQUID SUSPENSION IN AN UNBAFFLED STIRRED VESSELS BY A NOVEL PULSED LASER BASED IMAGE ANALYSIS TECHNIQUE
2009
The availability of experimental information on solid distribution inside stirred tanks is a topic of great importance in several industrial applications. The measurement of solid particle distribution in turbulent multiphase flow is not simple and the development of suitable measurement techniques is still in progress. In this work a novel non-intrusive technique for measuring particle concentration fields in solid-liquid systems is employed. The technique makes use of a laser sheet, a high sensitivity digital camera for image acquisition and a Matlab procedure for post-processing the acquired images. Experimental data are here obtained for the case of an unbaffled stirred tank. Stable tor…
A classical phenotype of Anderson-Fabry disease in a female patient with intronic mutations of the GLA gene: a case report
2012
Abstract Background Fabry disease (FD) is a hereditary metabolic disorder caused by the partial or total inactivation of a lysosomal hydrolase, the enzyme α-galactosidase A (GLA). This inactivation is responsible for the storage of undegraded glycosphingolipids in the lysosomes with subsequent cellular and microvascular dysfunction. The incidence of disease is estimated at 1:40,000 in the general population, although neonatal screening initiatives have found an unexpectedly high prevalence of genetic alterations, up to 1:3,100, in newborns in Italy, and have identified a surprisingly high frequency of newborn males with genetic alterations (about 1:1,500) in Taiwan. Case presentation We des…
Role of Type I and II Interferons in Colorectal Cancer and Melanoma
2017
Cancer can be considered an aberrant organ with a hierarchical composition of different cell populations. The tumor microenvironment, including the immune cells and related cytokines, is crucial during all the steps of tumor development. In particular, type I and II interferons are involved in a plethora of mechanisms that regulate immune responses in cancer, thus balancing immune escape versus immune surveillance. Interferons are involved in both the direct and indirect regulation of cancer cell proliferation and metastatic potential. The mutational background of genes involved in interferons signaling could serve as a prognostic biomarker and a powerful tool to screen cancer patients elig…
Reciprocal influence of B cells and tumor macro and microenvironments in the ApcMin/+ model of colorectal cancer
2017
One of the most fascinating aspects of the immune system is its dynamism, meant as the ability to change and readapt according to the organism needs. Following an insult, we assist to the spontaneous organization of different immune cells which cooperate, locally and at distance, to build up an appropriate response. Throughout tumor progression, adaptations within the systemic tumor environment, or macroenvironment, result in the promotion of tumor growth, tumor invasion and metastasis to distal organs, but also to dramatic changes in the activity and composition of the immune system. In this work, we show the changes of the B-cell arm of the immune system following tumor progression in the…
Tumor-Infiltrating γδ T Lymphocytes: Pathogenic Role, Clinical Significance, and Differential Programing in the Tumor Microenvironment.
2014
There is increasing clinical evidence indicating that the immune system may either promote or inhibit tumor progression. Several studies have demonstrated that tumors undergoing remission are largely infiltrated by T lymphocytes [tumor-infiltrating lymphocytes (TILs)], but on the other hand, several studies have shown that tumors may be infiltrated by TILs endowed with suppressive features, suggesting that TILs are rather associated with tumor progression and unfavorable prognosis. γδ T lymphocytes are an important component of TILs that may contribute to tumor immunosurveillance, as also suggested by promising reports from several small phase-I clinical trials. Typically, γδ T lymphocytes …
Study guidance experiences, study progress, and perceived learning outcomes of Finnish university students
2019
In recent decades, the massification and diversification of higher education have generated new challenges for the guidance of university students. The present study focuses on students’ experiences of guidance in relation to their study progress and perceptions of their learning outcomes. The data (n = 4916) were collected from 2010–2013 through yearly Internet surveys whose targeted respondents were the students of a Finnish University. According to the results, general study guidance was a very strong predictor of students’ self-assessed development of their academic and generic skills as well as working life orientation. It also decreased the probability of slow progress in studies. Sig…
Prevalence and morphometric analysis of the retromolar canal in a Spanish population sample: a helical CT scan study.
2021
BACKGROUND: The retromolar canal (RMC) is an anatomical variation of the mandibular canal (MC) whose identification and study should be considered given its implication in the surgical procedures of the retromolar area. The prevalence of the RMC widely varies according to previous studies and may be influenced by the followed study method. This work aimed to evaluate the prevalence of the RMC in a Spanish population sample. MATERIAL AND METHODS: For this purpose, 225 CT scan images (with a higher resolution than the cone beam CT used in other previous studies) from the Hospital Clinico Universitario de Valencia were analyzed. The Osirix MD radiological image analysis system was applied to a…
On several notions of complexity of polynomial progressions
2021
For a polynomial progression $$(x,\; x+P_1(y),\; \ldots,\; x+P_{t}(y)),$$ we define four notions of complexity: Host-Kra complexity, Weyl complexity, true complexity and algebraic complexity. The first two describe the smallest characteristic factor of the progression, the third one refers to the smallest-degree Gowers norm controlling the progression, and the fourth one concerns algebraic relations between terms of the progressions. We conjecture that these four notions are equivalent, which would give a purely algebraic criterion for determining the smallest Host-Kra factor or the smallest Gowers norm controlling a given progression. We prove this conjecture for all progressions whose ter…
Adaptive meshes in computer graphics and model-based simulation
2006
Monet luonnonlait voidaan ilmaista matemaattisesti joko yhtenä yhtälönä tai yhtälöjärjestelmänä. Erityisesti differentiaaliyhtälöiden ratkaisu on tärkeä esimerkiksi mekaniikassa, biologiassa tai kemiassa esiin tuleva ongelma. Useimmissa tapauksissa ratkaisu tällaisiin yhtälöihin on tuntematon, joten se täytyy löytää käyttäen tietokonekoodia. Koska tietokoneet toimivat rajoitetulla tarkkuudella ja tietomäärällä, tietokoneella saatu ratkaisu on vain approksimaatio yhtälön ratkaisulle. Tämän epätarkan tiedon käyttö tietokoneavusteisessa tekniikassa voi johtaa laitteen toimintahäiriöihin. Onkin tärkeää saada kuva, kuinka hyvin tietokoneella saatu tulos edustaa tarkkaa ratkaisua. Turchyn kehitti…
Cardiorenal syndrome type 4: From chronic kidney disease to cardiovascular impairment
2016
Cardiorenal syndrome type 4 (CRS type 4), or chronic renocardiac syndrome, has been defined as "chronic abnormalities in renal function leading to cardiac disease" and recognizes the extreme burden of cardiovascular disease (CVD) risk in patients with chronic kidney disease (CKD). CKD is common and increasingly recognized as a risk factor for CVD. Even though the treatment for CVD has dramatically improved over the past decades, it still takes responsibility for up to 50% of deaths in CKD patients. For this reason, patients with CKD should be thoroughly evaluated for cardiovascular risk factors that require careful management, given the significant burden of CRS type 4 on the healthcare sys…