Search results for " protocol"
showing 10 items of 1320 documents
Functioning of family system in pediatric oncology during treatment phase.
2012
The study focuses on parents’ psychological implications caused by the treatment of their children suffering from tumor. It investigates some specific mothers’ resource factors such as their strategies of coping and the perception of their own family functioning in terms of cohesion and adaptability. The study was performed with 34 mothers of children suffering from acute lymphoblastic leukemia(ALL),duringthetreatmentphase.TheusedtoolsweretheCopingOrientationtoProblem Experienced—New Italian Version, to investigate coping strategies, and the Family Adaptability and Cohesion Evaluation Scale-III, to analyze both real and ideal perception of family functioning. The data related to coping, show h…
Nanoseconds Timing System Based on IEEE 1588 FPGA Implementation
2019
Clock synchronization procedures are mandatory in most physical experiments where event fragments are readout by spatially dislocated sensors and must be glued together to reconstruct key parameters (e.g. energy, interaction vertex etc.) of the process under investigation. These distributed data readout topologies rely on an accurate time information available at the frontend, where raw data are acquired and tagged with a precise timestamp prior to data buffering and central data collecting. This makes the network complexity and latency, between frontend and backend electronics, negligible within upper bounds imposed by the frontend data buffer capability. The proposed research work describ…
Current questions for the treatment of advanced gastric cancer.
2013
Abstract Background Gastric cancer remains a major health problem worldwide. Treatment of advanced gastric cancer is controversial and there is no standard regimen for first- or second-line chemotherapy (CT). This review aims to give an overview of the hot topics concerning treatment, prognostic factors and new strategies in advanced gastric cancer. Material and methods Seven questions of special clinical interest have been formulated previously to the literature review. With the aim of answering each of these questions, a specific search of the relevant trials and meta-analyses published or communicated from 1990 to date was performed. Results Patients treated with CT have a survival benef…
Intrinsic fluorescence of the clinically approved multikinase inhibitor nintedanib reveals lysosomal sequestration as resistance mechanism in FGFR-dr…
2017
Background Studying the intracellular distribution of pharmacological agents, including anticancer compounds, is of central importance in biomedical research. It constitutes a prerequisite for a better understanding of the molecular mechanisms underlying drug action and resistance development. Hyperactivated fibroblast growth factor receptors (FGFRs) constitute a promising therapy target in several types of malignancies including lung cancer. The clinically approved small-molecule FGFR inhibitor nintedanib exerts strong cytotoxicity in FGFR-driven lung cancer cells. However, subcellular pharmacokinetics of this compound and its impact on therapeutic efficacy remain obscure. Methods 3-dimens…
Virtual Vehicles Manager: a java virtual reality environment for distributed multi vehicles dynamics control and simulation
2007
This paper describes a lightweight, full portable software environment for development, simulation and control of vehicles. All the software is developed in Java so there are many advantages as portability, multithreading distribution etc. This environment simulates the vehicles integrating their non-linear differential equation systems. The equation systems can easily be modified changing that representation class so it is easy to manage different vehicles. The scenario is displayed as a 3D virtual reality environment in which all the objects are rendered using a combination of 3 d primitive. It is also possible the use of pre-built 3 d objects loaded from files in 3 ds format. The softwar…
Adaptogens in chemobrain (Part I): Plant extracts attenuate cancer chemotherapy-induced cognitive impairment – Transcriptome-wide microarray profiles…
2019
Abstract Background Cancer chemotherapy-induced cognitive impairments are presumably associated with undesirable effects of chemotherapy on physiological functions of brain cells. Adaptogens are natural compounds or plant extracts increasing an organism's adaptability and survival in stress. They exhibited neuroprotective effects and increased cognitive functions in clinical studies in human beings. Hypothesis We hypothesized that selected adaptogenic plant extracts attenuate or prevent cancer chemotherapy-induced cognitive impairments. Aim We assessed the effects of selected adaptogenic herbal extracts on FEC (fixed combination 5-fluorouracil, epirubicin and cyclophosphamide) induced chang…
Rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART): study protocol for a randomized controlled trial.
2012
Abstract Background Acute respiratory distress syndrome (ARDS) is associated with high in-hospital mortality. Alveolar recruitment followed by ventilation at optimal titrated PEEP may reduce ventilator-induced lung injury and improve oxygenation in patients with ARDS, but the effects on mortality and other clinical outcomes remain unknown. This article reports the rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART). Methods/Design ART is a pragmatic, multicenter, randomized (concealed), controlled trial, which aims to determine if maximum stepwise alveolar recruitment associated with PEEP titration is able to increase 28-day survival in patients with …
Individual and environmental factors underlying life space of older people – study protocol and design of a cohort study on life-space mobility in ol…
2012
Abstract Background A crucial issue for the sustainability of societies is how to maintain health and functioning in older people. With increasing age, losses in vision, hearing, balance, mobility and cognitive capacity render older people particularly exposed to environmental barriers. A central building block of human functioning is walking. Walking difficulties may start to develop in midlife and become increasingly prevalent with age. Life-space mobility reflects actual mobility performance by taking into account the balance between older adults internal physiologic capacity and the external challenges they encounter in daily life. The aim of the Life-Space Mobility in Old Age (LISPE) p…
Elotuzumab, lenalidomide, and dexamethasone as salvage therapy for patients with multiple myeloma: Italian, multicenter, retrospective clinical exper…
2020
No abstract available
Seed germination reports for coastal sand dune species from Sicily
2019
This study investigated seed germination in nine psammophilous species occurring in Sicilian sand dunes, some of which, such as Muscari gussonei, Launaea resedifolia and Pancratium maritimum, are endemic and/or rare and very scattered in the area. Different germination protocols were tested for one or more populations and the best germination results per species are provided, reporting experimental conditions and specific comments on the germination behaviour.