Search results for " protocol"
showing 10 items of 1320 documents
Adverse events associated with encorafenib plus binimetinib in the COLUMBUS study: incidence, course and management.
2019
Abstract Background Dual inhibition of the mitogen-activated protein kinase pathway with BRAF/MEK inhibitor (BRAFi/MEKi) therapy is a standard treatment for BRAFV600-mutant metastatic melanoma and has historically been associated with grade III pyrexia or photosensitivity depending on the combination used. The objective of this study was to fully describe adverse events from the COLUMBUS study evaluating the most recent BRAF/MEK inhibitor combination encorafenib+binimetinib. Patients and methods Patients with locally advanced, unresectable or metastatic BRAFV600-mutant melanoma were randomised to receive encorafenib 450 mg once daily plus binimetinib 45 mg twice daily, encorafenib 300 mg on…
Membrane-bound exosomal HSP70 as a biomarker for detection and monitoring of malignant solid tumours: a pilot study
2019
Abstract Background Cancer is the second leading cause of death globally. Early detection and disease management lead to a better survival rate. Consequently, discovery of novel methods in cancer early diagnosis is a field of active research. Minimally invasive liquid biopsies are generating growing interest. Circulating tumour cells (CTCs) have been identified in patients’ blood; nevertheless, these cells are rare and heterogeneous. Exosomes are extracellular nanovesicles released into the extracellular environment via the endosomal vesicle pathway and found in different body fluids. Exosomes deliver bioactive cargo such as proteins, mRNA and miRNA to recipient cells in the tumour environm…
ERCP : Energy-Efficient and Reliable-Aware Clustering Protocol for Wireless Sensor Networks
2022
Wireless Sensor Networks (WSNs) have been around for over a decade and have been used in many important applications. Energy and reliability are two of the major problems with these kinds of applications. Reliable data delivery is an important issue in WSNs because it is a key part of how well data are sent. At the same time, energy consumption in battery-based sensors is another challenge. Therefore, efficient clustering and routing are techniques that can be used to save sensors energy and guarantee reliable message delivery. With this in mind, this paper develops an energy-efficient and reliable clustering protocol (ERCP) for WSNs. First, an efficient clustering technique is proposed for…
DSC: software tool for simulation-based design of control strategies applied to wastewater treatment plants.
2011
This paper presents a computer tool called DSC (Simulation based Controllers Design) that enables an easy design of control systems and strategies applied to wastewater treatment plants. Although the control systems are developed and evaluated by simulation, this tool aims to facilitate the direct implementation of the designed control system to the PC of the full-scale WWTP (wastewater treatment plants). The designed control system can be programmed in a dedicated control application and can be connected to either the simulation software or the SCADA of the plant. To this end, the developed DSC incorporates an OPC server (OLE for process control) which facilitates an open-standard communic…
OLSR Mesh Networks for Broadband Access: Enhancements, Implementation and Deployment
2008
In the context of an EU FP6 project, ADHOCSYS, we have developed a reliable and cost-effective solution for broadband Internet access in rural and mountainous areas. This solution is built based on multi-hop wireless mesh networking technologies and covers many aspects such as routing, reliability, QoS, security, self-configuration, self-healing, remote network monitoring, power management etc. In this paper, we present solely the routing aspect of the developed mesh network, focusing on new routing features that have been designed, implemented, and deployed in a real-life operational network. These new features are developed based on an extended version of the OLSR protocol. The test resul…
comparing two start-up strategies for MBRs: experimental study and mathematical modelling
2012
Abstract The performance of a membrane bioreactor (MBR), and mechanisms of fouling formation, may differ due to the start-up. Therefore, the start-up can constitute an aspect that critically influences MBR performance during its lifespan. Indeed, the start-up can influence the mechanisms of membrane fouling, which is of paramount importance in an MBR. In order to gain insights on the effects of the start-up, both experimental and mathematical modelling studies were carried out on an MBR pilot plant. The MBR pilot plant constituted of a hollow fibre membrane module, in a submerged configuration, was fed by real wastewater. Two experimental periods were carried out, lasting 65 days each, char…
Understanding flow experience from users’ requirements
2015
This paper argues that the concept of flow can be useful in gaining a better understanding of information system users’ flow experience. This paper applies this concept in the requirements development phase of an Internet protocol television e-learning service development project. The findings show that flow experience can be visualised and measured, and that there are differences in how users see and perceive different features. Some features are driven by more experiential needs, whereas others are driven by more task-oriented goals. The findings indicate that the users’ perceived flow experiences can already be measured during the early phases of information systems IS development projec…
Remote programming of network robots within the UJI Industrial Robotics Telelaboratory: FPGA vision and SNRP network protocol
2009
This paper presents the UJI Industrial Robotics Telelaboratory, which lets Ph.D. and Master’s degree students perform robotics and computer vision tele-experiments. By using this system, students are able to program experiments remotely via the Web, in order to combine the use of a field-programmable gate array (FPGA) to provide real-time vision processing, a conveyor belt, and a Motoman industrial manipulator. This paper introduces the novel SNRP protocol (i.e., Simple Network Robot Protocol), which permits the integration of network robots and sensors within an e-learning platform in a simple and reliable manner. As long as the students are able to interact remotely with a real robotic sc…
Remote control within the UJI Robotics Manufacturing Cell using FPGA-based vision
2007
In this paper we present a work in progress of a new remote control system based on networked robots and FPGAs technology. The experimental validation has been carried out within the UJI (i.e. the acronym for University Jaume I) Robotics Manufacturing Cell. The main devices included in this Cell are: a SCARA manipulator (AdeptOne), a robot arm with six degrees of freedom (Motoman), an industrial belt, several sensors and cameras, an FPGA that takes care of the computer vision algorithms (i.e. including grasping determination), and a distributed architecture that allows any user to control remotely via Internet a specific manufacturing task. The different components of this system are connec…
Life cycle assessment of a solar thermal collector: sensitivity analysis, energy and environmental balances
2005
Abstract Starting from the results of a life cycle assessment of solar thermal collector for sanitary warm water, an energy balance between the employed energy during the collector life cycle and the energy saved thanks to the collector use has been investigated. A sensitivity analysis for estimating the effects of the chosen methods and data on the outcome of the study was carried out. Uncertainties due to the eco-profile of input materials and the initial assumptions have been analysed. Since the study is concerned with a renewable energy system, attention has been focused on the energy indexes and in particular the “global energy consumption”. Following the principles of Kyoto Protocol, …